DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42672 and kdin-1

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_001294014.1	Gene:	kdin-1 / 178000	WormBaseID:	WBGene00006490	Length:	1484	Species:	Caenorhabditis elegans

Alignment Length:	1550	Identity:	457/1550 - (29%)
Similarity:	767/1550 - (49%)	Gaps:	264/1550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 RDENATTVLMVVAGRGLTAFVREFLARGAD-VQAEDLDNWTALLCASRNGHLDVVQLLLDHGAEV 262
            |:.|..::|.|....|.||..::......| :...|.:.|:|||.|:..||:|:|:||:|:||.|
Worm    58 RNANGESLLTVAVRSGNTAVAKQLAQLDPDAIDETDNEGWSALLNAAHCGHVDIVRLLIDNGASV 122

  Fly   263 EHRDMGGWTSLMWAAYRGHTELVRLLLDKGADGNAHGNY-----HLGALLWAAGRGYKDIVELLV 322
            :..|:.||:.||||.|:.|.::|.||:    :..||.|.     .|..|:.|:|||:..|||.|:
Worm   123 DQPDLMGWSPLMWAVYKNHLDVVDLLV----NAKAHVNLIDEEDGLTPLIVASGRGFSQIVERLI 183

  Fly   323 QRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAGANVDTAGMYSWTPLLVAAAGGHTDCVSSI 387
            ....:||..||:|:|||:||.|:|::.:|..||.:||.||..||||.|.|::|..|.....|..:
Worm   184 DSDCQVNACDKFGSTALIWAARKGHLPVVQLLLNSGAEVDAVGMYSSTALMLATRGNFIQVVELL 248

  Fly   388 LEKKPNVNALDKDGMTALCIASREGFQDIAASLIAAGAYINIQDRGADTPLIHAVKAGHRTVVEA 452
            |.::||||..|::|:|||.:|:|:|:.||..|||.:||::|..||..:..|..||::|:..:|..
Worm   249 LTREPNVNVADQNGLTALGMAARDGYADICESLINSGAFVNQCDRFGNWILTSAVRSGNAAIVRM 313

  Fly   453 LLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPLLRAVRNRNLEIVH 517
            :|.|.||::.|..:::|.::.|::|....|..:||...|:||...|||:||||||.:.|::.:..
Worm   314 ILDKFADINCQDSEKRTPLHLAIDKSFNDIAYILLEKKPNLELKNKDGETPLLRAAKCRHVHLCT 378

  Fly   518 LLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALLRNPKHSQLLYRANKAGETPYNIDSLHQKT 582
            .|:...||:.|.|..||..||:|:||||:.:.:|||.||..|:||||.||.|:|||:||..:.:.
Worm   379 YLMSFGAKLAAVDNCGDNALHLALRARSRRLTQALLSNPSDSRLLYRPNKLGQTPYSIDLSNPQP 443

  Fly   583 ILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSEPTLTTPITVGLYAKWGSGKSFLLNKLRDE 647
            ||..:||.  ::..:..:..:||::||:.|||::.||:|:.|:|:|||||||||||.||.||::.
Worm   444 ILPLIFGP--IDAEDKMDTAMGYDVYSNVLADIVCEPSLSLPLTIGLYAKWGSGKSALLAKLKEA 506

  Fly   648 MNNFARQWAEPPIRTSGLLFIVCLHVALLIGTIVGL--STWSAVVGVSAAVGFLLLAY--LLLAA 708
            |::|:|.|.:      |:...|...:...|....|:  .|::.::.:|.:|...|:::  .||..
Worm   507 MHSFSRDWLD------GVSLSVSFALFFAIFLFFGMFSLTFTMLIAISNSVTAYLISWSVFLLIF 565

  Fly   709 VRYCN-----YQMDMQ-W--AYSVQHGLEKRMTRLRLILQVAFCHPPGPQSDSQAKPVRFHFAEA 765
            :.:|:     |..|.: |  :..:.:...:..:|:||:..:...|.|....||.:.||.|.||:.
Worm   566 IIFCSLIVVVYYGDRKNWYTSMDIANFFARVFSRIRLVYNILTLHAPMNSEDSASMPVSFLFADY 630

  Fly   766 NSASPT-GDGAVAHMLAALLDAIESHYGWLATRLYRAFRPKCLKVDVGWRW-------------- 815
            :..|.. |:.|:|.::|.|.:|.|:|:|.|..||:...:|....:|.|:.:
Worm   631 HRLSSIGGEQALAKIVATLFEAAETHFGVLPVRLFCCMKPPYQYIDTGFGFTSPFSRTTYRSLQQ 695

  Fly   816 -------------RRMCCIP-IVLIFELALVTVVTGISLTVAYFTFADEKEKEHILVALYVIAAV 866
                         ||.|.:| ::|:.....:.::..:..||...:..|...     ..|::..|.
Worm   696 PNAHQQAGIHGSLRRHCGVPHVILLIVAVFLLIMAQVFGTVWLLSDRDPNN-----FNLFIAIAF 755

  Fly   867 MGTLICTHLHVLAKVFVSLFTSHIRVLKRAVRSSE--------SAPLTMLGAEVAVMTDMVKCLD 923
            :...:...::.||.:.:..:|:   |.:|.|.::.        ...:..|..||.::.||::.||
Worm   756 LCGFVMIAIYPLALIIMYSWTN---VPRRRVNAAARNAHKLRFEGLMQKLQTEVDLLADMIRSLD 817

  Fly   924 AFTNQQSRLVGVIDALDSCDTERILTLLNAVQTLLSS-PNRPFVLLISVDPHVIAKAAEANSRRL 987
            |||...:|||.|:|.||:|:.||::..|:|::.|.|: .:|||:.:|:||||||..|...|....
Worm   818 AFTRSHTRLVVVVDGLDNCEQERMVQTLDALELLFSARKHRPFITIIAVDPHVIVSAINHNMHSA 882

  Fly   988 FTEGGIGGHDFLRNLVHLPVYLQNSGLRKVQRAQMTALLFKRSGGGDYQTDDGPTLGHSVSARRL 1052
            .:...:.|||:|:|::.:|.||.||.||::|    :.|..||....:::             .|.
Worm   883 LSGTELTGHDYLKNIISMPFYLHNSALRQLQ----SKLREKRESMAEWK-------------ERF 930

  Fly  1053 SNASEIISSQEKLRGPARGGGGKKLRLSESVASSTGSNLHR---LGQNPQTVLDLSRIVLTDDYF 1114
            ........|...|| .|.|...:|     |...||..|::.   :|:|      ::..:|.:|||
Worm   931 KRQDTFYGSHLSLR-EADGRTSRK-----SFQKSTVPNMNSNSVVGRN------MNDGILGEDYF 983

  Fly  1115 SDVNPRSMRRLMNVIYITVRLLKAFQIEFSWYRLSSWINLTEQWPLRASMIV-----LHHDQFMD 1174
            |::|||:|||::|.:.:|.||::||:|:|||..|..|::|.||||.|...::     :|::|.:
Worm   984 SNMNPRAMRRIVNALTLTGRLMRAFEIDFSWMSLGHWVSLLEQWPSRMCWLIDRALEVHNNQLL- 1047

  Fly  1175 SNADESVSLQSVYEKLRPKLAYLREAAPLLELDRDERKLDAFLQL----HKSDLLVADLRIFLPF 1235
                    |..||.:|:.   ::.....|::|||:....:.||..    ....|.|..::.|:|.
Worm  1048 --------LSEVYYQLKD---HIPAQDDLMQLDRNLENFEGFLDSKGIPSAERLTVGHVKKFVPC 1101

  Fly  1236 TINLDPYLRKVLKEDQQTIEDEGSLVIQARPSVSNTMRQFPAPTTYVPSPQAYPPYQMFQNEYPA 1300
            |.:|||||||:::|     ..:|.:.|:|:...:.               .|.||
Worm  1102 TSSLDPYLRKLIRE-----RSKGLVDIEAQVGSAG---------------MAIPP---------- 1136

  Fly  1301 NELRSRNLSTSTEPVTPLINSPSDSFGDDI----LQTKLTDLTVEGVISLLDRIEDMKPALPKLA 1361
               .:|.|                 |.||:    :.|.|.::.::.|::|:.:|:.....|..:.
Worm  1137 ---NARLL-----------------FSDDLTWMSIDTPLVEMKLDAVVNLIRKIDIPSNRLDSIL 1181

  Fly  1362 PVLRENAINGRVLKHCDMPDLKSVLGLSFGHWELFRLLITTLRECERLP-------------RKQ 1413
            ....:..:.|.||..|.:|:||..:.|..|.|.|.|||:.||:.....|             |::
Worm  1182 DRFYQLNLCGLVLATCPLPELKDSMQLPLGDWTLIRLLLETLKVFGSSPPGLRVDKRKALTLREE 1246

  Fly  1414 QRQQQQPGALEAPSN-----VPMIKDVTDALMQPPRESLSRKN----SVSH---MEKQVTLEEQM 1466
            ..:::...|.||..|     .|::..|.   .:..|.|...:|    |:.|   |||   |....
Worm  1247 DEEEEIEEAAEAALNSEKERAPLLGSVR---AEQRRRSTIVQNATELSIDHKCLMEK---LSGMD 1305

  Fly  1467 ICGTLQTLNEEAYEDVASS-ERPSPTELDTPSAGAAMTTPLLGASGSVPAPS------------- 1517
            :..|...:||..:...:|| :.|||           |....|.||.|. |||
Worm  1306 LTETEGDVNEMHFSHFSSSTDGPSP-----------MADGFLPASVSA-APSVRFDDNINDLERE 1358

  Fly  1518 ------------GRESILKQQGSVKADKRVSIQQMATSNNNNN---NSTKLTPNVEYVSERQPEV 1567
                        .:|::|:.:.|......|.:.:..:.|.:::   :|.:.:.....:| |...:
Worm  1359 ASDADSTQSRYDSKENLLEDERSASPPAHVDLMRFDSGNTSSDFVRSSYRTSSRYRRMS-RGDLM 1422

  Fly  1568 QGAGKRLTTKPP-------PGPRPASLIITRNDSNSQFQLLRSSSVDYDDVEAQE 1615
            :|..:..|.:..       ..|..:||:.:..|.|.| .:.|....|::.::.::
Worm  1423 RGMHQNDTIRSSMDQSGTGAAPSSSSLMASDEDLNQQ-TVQRRGGDDFERIQLEQ 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	35/90 (39%)
		Ank_2	173..266	CDD:289560	24/67 (36%)
		ANK repeat	205..233	CDD:293786	6/28 (21%)
		ANK	231..355	CDD:238125	54/128 (42%)
		ANK repeat	235..266	CDD:293786	15/30 (50%)
		Ank_2	240..332	CDD:289560	40/96 (42%)
		ANK repeat	268..299	CDD:293786	12/30 (40%)
		ANK repeat	301..332	CDD:293786	12/35 (34%)
		Ank_2	306..398	CDD:289560	42/91 (46%)
		ANK	329..454	CDD:238125	55/124 (44%)
		ANK repeat	334..362	CDD:293786	13/27 (48%)
		ANK repeat	367..398	CDD:293786	12/30 (40%)
		ANK repeat	400..431	CDD:293786	15/30 (50%)
		Ank_4	401..454	CDD:290365	22/52 (42%)
		ANK	428..553	CDD:238125	47/124 (38%)
		ANK repeat	435..464	CDD:293786	9/28 (32%)
		Ank_2	438..530	CDD:289560	33/91 (36%)
		ANK repeat	466..497	CDD:293786	9/30 (30%)
		ANK repeat	499..530	CDD:293786	13/30 (43%)
		Ank_5	518..575	CDD:290568	30/56 (54%)
		KAP_NTPase	605..1136	CDD:284995	167/583 (29%)
		SAM_superfamily	1357..1392	CDD:188886	9/34 (26%)
kdin-1	NP_001294014.1	ANK repeat	61..93	CDD:293786	7/31 (23%)
		PHA02874	66..>370	CDD:165205	126/307 (41%)
		ANK repeat	95..126	CDD:293786	15/30 (50%)
		ANK repeat	128..193	CDD:293786	26/68 (38%)
		ANK repeat	162..190	CDD:293786	10/27 (37%)
		ANK repeat	195..225	CDD:293786	15/29 (52%)
		ANK repeat	228..259	CDD:293786	12/30 (40%)
		ANK repeat	261..292	CDD:293786	15/30 (50%)
		ANK repeat	327..358	CDD:293786	9/30 (30%)
		Ank_2	332..419	CDD:372319	37/86 (43%)
		ANK repeat	360..391	CDD:293786	13/30 (43%)
		KAP_NTPase	464..1005	CDD:284995	167/583 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I1440
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14254
Inparanoid	1	1.050	618	1.000	Inparanoid score	I484
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46561
OrthoDB	1	1.010	-	-		D38210at33208
OrthoFinder	1	1.000	-	-		FOG0006003
OrthoInspector	1	1.000	-	-		oto20060
orthoMCL	1	0.900	-	-		OOG6_106563
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3637
SonicParanoid	1	1.000	-	-		X4301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910