Protein Alignment Arms and Arms

DIOPT Version :10

• Sequence 1: NP_726059.5
• Gene: Arms / 37433
• FlyBaseID: FBgn0261554
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: XP_061511757.1
• Gene: Arms / 1280536
• VectorBaseID: AGAMI1_006962
• Length: 1716
• Species: Anopheles gambiae
• Alignment Length: 1728
• Identity: 956/1728 - (55%)
• Similarity: 1155/1728 - (66%)
• Gaps: 263/1728 - (15%)

  Fly     1 MPKDGHSRKPQKRASIAEETPVSDSTTPATTASPSSPSRTA----GHSTIGALVSNLHHHDIQSL 61
            ||.||     |:||:           .....|.||.|:.:|    |:|.||:..:.|..|   .|
Mosquito    76 MPADG-----QERAA-----------ADGAAAPPSRPAESATSAPGNSIIGSTPTRLLQH---RL 121

  Fly    62 HQPLLESEERVIVAVNHRNPRQPHRSYGTERKPHSSLPRFVINIEEETDAAVAAAEGKSSPAPNQ 126
            ..|.|       |..:..:|..|.........|..:.|
Mosquito   122 RIPSL-------VVTSSLSPYHPGNLLAATADPDHTTP--------------------------- 152

  Fly   127 EHEEHSNQSPSRRFS------HFNLALRRFSHIHAHNINRFGDSMGSLGHRALLQYIDNNDISGL 185
                       ||||      |.|.||.|.            |||||||||:||||::.:|::||
Mosquito   153 -----------RRFSFAIMRRHSNTALNRC------------DSMGSLGHRSLLQYLETDDLAGL 194

  Fly   186 RAILDSRHLTIDDRDENATTVLMVVAGRGLTAFVREFLARGADVQAEDLDNWTALLCASRNGHLD 250
            ::.|.:|||.:||||||.||||||.:|||.|.||:|.|||||||||:|||:||||..|::.||:.
Mosquito   195 KSFLGTRHLQVDDRDENNTTVLMVASGRGATHFVKELLARGADVQAQDLDSWTALHFAAKAGHVG 259

  Fly   251 VVQLLLDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGADGNAHGNYHLGALLWAAGRGYK 315
            :|:||||:|||:|||||||||:|||.:|:|||.:|.|||.:|||..|||||||..||||:|||:.
Mosquito   260 IVELLLDNGAELEHRDMGGWTALMWGSYKGHTSVVALLLQRGADVQAHGNYHLNPLLWASGRGHT 324

  Fly   316 DIVELLVQR-GAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAGANVDTAGMYSWTPLLVAAAGG 379
            :||.|||.. |||||||||||||.||||||:|:.||||.||||||||||||||||||||||.:||
Mosquito   325 EIVRLLVNTGGAKVNVGDKYGTTPLVWACRKGSAEIVDVLLKAGANVDTAGMYSWTPLLVAVSGG 389

  Fly   380 HTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAASLIAAGAYINIQDRGADTPLIHAVKA 444
            ..:|||.:||:|||||||||||||||.||.|||..:||::|||||||:|:|||..|||||:|||.
Mosquito   390 FQECVSLLLERKPNVNALDKDGMTALSIACREGLTEIASALIAAGAYLNVQDRAGDTPLINAVKG 454

  Fly   445 GHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPLLRAVR 509
            |||:|||.|:|:|.||||||||:|||:|||||||||.||||:|.:|||||.:||||||.||||||
Mosquito   455 GHRSVVEILMKRHVDVDIQGKDKKTALYTAVEKGHTAIVKLILQSNPDLELSTKDGDTALLRAVR 519

  Fly   510 NRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALLRNPKHSQLLYRANKAGETPYN 574
            |||||||.:||:|||||.|:|||||||||:|||||||.||||||.|||:.|||||:||.|||||.
Mosquito   520 NRNLEIVQMLLERKAKVGATDKRGDTCLHVAMRARSKAIVEALLSNPKYGQLLYRSNKEGETPYA 584

  Fly   575 IDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSEPTLTTPITVGLYAKWGSGKSF 639
            ||:.|||||||||||.||||.||||||||||.|||||||||||||||||||||||||||||||||
Mosquito   585 IDATHQKTILGQVFGNRRLNANEDSEGMLGYGLYSSALADVLSEPTLTTPITVGLYAKWGSGKSF 649

  Fly   640 LLNKLRDEMNNFARQWAEPPIRTSGLLFIVCLHVALLIGTIVGLSTWSAVVGVSAAVGFLLLAYL 704
            ||.:|||||.|||..|:||||..|.|.|::.||:.|:|||:|||:|||.|.|:......|:|.|.
Mosquito   650 LLTELRDEMKNFAHSWSEPPIDASWLFFLISLHLVLVIGTVVGLATWSYVWGMVTGATLLVLIYF 714

  Fly   705 LLAAVRYCNYQMDMQWAYSVQHGLEKRMTRLRLILQVAFCHPPGPQSDSQAKPVRFHFAEANSAS 769
            ....:::.:.:.|::|.||:.:||.:::.|||||||||||||||||||.|..|||||||||:.|:
Mosquito   715 TDILLKFLDRRYDLEWLYSLNYGLSRKLGRLRLILQVAFCHPPGPQSDQQPMPVRFHFAEASGAA 779

  Fly   770 PTGDGAVAHMLAALLDAIESHYGWLATRLYRAFRPKCLKVDVGWRWRRMCCIPIVLIFELALVTV 834
            |.||.|||.|||:|.||||:|||.|||.||||||||.||...||:||:|||:|:||:|||.::.:
Mosquito   780 PNGDAAVALMLASLFDAIEAHYGSLATGLYRAFRPKPLKATGGWKWRKMCCMPVVLMFELGMLGI 844

  Fly   835 VTGISLTVAYFTFADEKEKEHILVALYVIAAVMGTLICTHLHVLAKVFVSLFTSHIRVLKRAVRS 899
            :...||::.|..:..| .:|.|.||:||:..::......:||..:|:..:||.|..:.||||..|
Mosquito   845 LATASLSIVYSEYGLE-GREEIAVAIYVLLGILLAGAIANLHAWSKLIGALFMSQGKHLKRAFNS 908

  Fly   900 SESAPLTMLGAEVAVMTDMVKCLDAFTNQQSRLVGVIDALDSCDTERILTLLNAVQTLLSSPNRP 964
            :|:||||.|||||::|||||:||||||.||||||||:||||||||||.||:|||||||||.|.||
Mosquito   909 NEAAPLTALGAEVSLMTDMVRCLDAFTGQQSRLVGVVDALDSCDTERTLTILNAVQTLLSGPQRP 973

  Fly   965 FVLLISVDPHVIAKAAEANSRRLFTEGGIGGHDFLRNLVHLPVYLQNSGLRKVQRAQMTAL-LFK 1028
            ||||::|||||||||||||||||||||||||||||||||||||||||||||||||||.||: .::
Mosquito   974 FVLLLAVDPHVIAKAAEANSRRLFTEGGIGGHDFLRNLVHLPVYLQNSGLRKVQRAQNTAMSAYR 1038

  Fly  1029 RSGGGDYQTDDGPTLGHSVSARRLSNASEIISSQEKLRG-PARG-GGGKKLRLSESVASSTGSNL 1091
            |:.....:.||.|.||||.|.|||||||||:|||||||. |:.. ||.||||:|:|:|||.||||
Mosquito  1039 RAMPDLSRDDDQPHLGHSASVRRLSNASEIMSSQEKLRAMPSSSRGGSKKLRVSDSIASSIGSNL 1103

  Fly  1092 HRLGQNPQTVLDLSRIVLTDDYFSDVNPRSMRRLMNVIYITVRLLKAFQIEFSWYRLSSWINLTE 1156
            |:|||||.  :|||:|:|||||||||||||||||||||||||||||||||:||||||||||||||
Mosquito  1104 HKLGQNPP--VDLSKIILTDDYFSDVNPRSMRRLMNVIYITVRLLKAFQIDFSWYRLSSWINLTE 1166

  Fly  1157 QWPLRASMIVLHHDQFMDSNADESVSLQSVYEKLRPKLAYLREAAPLLELDRDERKLDAFLQLHK 1221
            |||||||||||.|||..|| .|:|||||:||:|:||||..|||||.||:||||||||||||||||
Mosquito  1167 QWPLRASMIVLEHDQGGDS-FDDSVSLQAVYDKVRPKLTCLREAAALLDLDRDERKLDAFLQLHK 1230

  Fly  1222 SDLLVADLRIFLPFTINLDPYLRKVLKEDQQTIEDEGSL-------------------------- 1260
            |||||:|||||||||||||||||||||||||.:||||.:
Mosquito  1231 SDLLVSDLRIFLPFTINLDPYLRKVLKEDQQALEDEGIIIPMKTVLPPSKPSGFVPHHHHRAPVG 1295

  Fly  1261 -VIQARPSVSNTMRQFPAPTTYVPSPQAYPPYQMF-QN--------------------------- 1296
             |:|..|...|.:..:  |..|.|.|||......: ||
Mosquito  1296 GVLQPTPQHPNNLTNW--PNFYNPQPQAMALMSYYNQNWANFPAGVYGTNALLGEPLPKPGSVGG 1358

  Fly  1297 -----EYPANELRS---RNLSTSTEPVTPLINSPSDS-------FGDDILQTKLTDLTVEGVISL 1346
                 |:|.:|..|   .|...|::..|..:...|.:       ...|:...:|:.||||.:|.|
Mosquito  1359 GPIITEHPPHEQHSTLGSNSGRSSKTTTGALQKSSSNGLATSPPIDIDLSNVQLSSLTVEQLIEL 1423

  Fly  1347 LDRIEDMKPALPKLAPVLRENAINGRVLKHCDMPDLKSVLGLSFGHWELFRLLITTLRECERLPR 1411
            |:::.|:|||:.:.||:||||||:||||.:|::.:|||||.|||||||:|:||:|.|||.
Mosquito  1424 LEKVNDLKPAMERTAPILRENAISGRVLMYCNLEELKSVLRLSFGHWEMFKLLVTALREA----- 1483

  Fly  1412 KQQRQQQQPGALE-APSNVPMIKDVTDAL-MQ-------PPRESLS------RKNSVSHMEK--- 1458
                ...||.:.: :.......|...|:: ||       ||..|.:      |:.|.:.:||
Mosquito  1484 ----SVTQPASRKLSTKTTSFAKGTNDSVEMQEPIAQSTPPFGSSTSSFQPIRQKSQNLLEKQPA 1544

  Fly  1459 --------QVTLEEQMICGTLQTLNEEAYED-VASSERPSPT---------------ELDTP--- 1496
                    |||||||||||.||||||:|:|| |:||||||||               |:.:|
Mosquito  1545 KVHDYEYLQVTLEEQMICGALQTLNEDAFEDVVSSSERPSPTGEMFSQYLAPIRESSEIGSPPRL 1609

  Fly  1497 ------------------------SAGAAMTTPLLGASGSVPAPSGRESILKQQGSVKADKRVSI 1537
                                    ..|...:..:.|..|.....||....|: .||.:..:..|:
Mosquito  1610 TYNLTNPNLTDLAASNGTLNGDDSGVGGGGSVGVGGGGGGGSTSSGSHLGLR-SGSGRHSRSHSL 1673

  Fly  1538 QQMAT------------------SNNNNNNSTKLTPNV 1557
            ...|:                  |:|||||:...|.|:
Mosquito  1674 HDDASLTSIVVIPTFLTTSPNGASSNNNNNNNNTTTNI 1711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arms	NP_726059.5	ANKYR	172..438	CDD:440430	187/266 (70%)
		ANK repeat	205..233	CDD:293786	21/27 (78%)
		ANK repeat	235..266	CDD:293786	18/30 (60%)
		ANK repeat	268..299	CDD:293786	19/30 (63%)
		ANK repeat	301..332	CDD:293786	21/31 (68%)
		ANKYR	316..598	CDD:440430	220/282 (78%)
		ANK repeat	334..362	CDD:293786	22/27 (81%)
		ANK repeat	367..398	CDD:293786	22/30 (73%)
		ANK repeat	400..431	CDD:293786	21/30 (70%)
		ANK repeat	435..464	CDD:293786	21/28 (75%)
		ANK repeat	466..497	CDD:293786	23/30 (77%)
		ANK repeat	499..530	CDD:293786	25/30 (83%)
		KAP_NTPase	605..1136	CDD:462231	356/533 (67%)
		SAM_superfamily	1357..1392	CDD:188886	21/34 (62%)
Arms	XP_061511757.1	None