DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42672 and ANKS3

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	XP_011520674.1	Gene:	ANKS3 / 124401	HGNCID:	29422	Length:	668	Species:	Homo sapiens

Alignment Length:	645	Identity:	137/645 - (21%)
Similarity:	215/645 - (33%)	Gaps:	206/645 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 GADVQAEDLDNWTALLCASRNGHLDVV-QLLLDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLL 289
            |..|..|:||....|..|:..|..:|| :.:.....::..::.||||.||:|:|.||..:|.|||
Human    37 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLL 101

  Fly   290 DKGADGNAHGNYHLGALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTL 354
                                             :.|..|||....|.|.|:.|...||..|...|
Human   102 ---------------------------------EAGVSVNVPTPEGQTPLMLASSCGNESIAYFL 133

  Fly   355 LKAGANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAAS 419
            |:.||.::...:..||.|....:.||...|..:|:...|.|..:     .:|     ||
Human   134 LQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVRE-----PIC-----GF------ 182

  Fly   420 LIAAGAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVK 484
                            |||:.|..|||..:|:..|.....||.:.....||...|.:.||..||.
Human   183 ----------------TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVA 231

  Fly   485 LLLATNP--------------DLESATKDGDTP-LLRAVRNRNLEIVHLLLDRKAKVTASDKRGD 534
            |:...:|              ||.|:.:....| ..|..|.:.:.| |......|::|.
Human   232 LMDTYSPSLPKSLYRSPEKYEDLSSSDESCPAPQRQRPCRKKGVSI-HEGPRALARITG------ 289

  Fly   535 TCLHIAMRARSKTIVEALLRNPKHSQLLYRA----NKAGETPYNIDSLHQKTILGQVFGARRLNT 595
                |.:..|:.        .|::.|...|.    |.:||.|...:.|..:.:...:
Human   290 ----IGLGGRAP--------RPRYEQAPPRGYVTFNSSGENPLEEEGLCCRDVTSPI-------- 334

  Fly   596 NEDSEGMLGYELYSSALADVLSE--------PTLTTPITVGLYAKWGSGKSFLLNKLRDE---MN 649
            ||       .::.||:.:....|        |..::..:.||....|......:....|.   ..
Human   335 NE-------RDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARAQGLSSEASVESNEDSDHACK 392

  Fly   650 NFARQWAEPPIRTSGLLFIVCLHVALLIGTIVGLSTWSAVVGVSAAVGFLL-------------- 700
            :.||:.|:..::|..                 ..|.|......... |||.
Human   393 SSARKQAKSYMKTKN-----------------PDSQWPPRAATDRE-GFLAESSPQTQRAPYSGP 439

  Fly   701 --LAYLL--LAAVRYCNYQMDMQWAYSVQHGLEKRMTRLRLILQVA-----------FCHPPGPQ 750
              ||.||  :..::|...             .|::...||:.|.:.           |    ||:
Human   440 QDLAALLEQIGCLKYLQV-------------FEEQDVDLRIFLTLTESDLKEIGITLF----GPK 487

  Fly   751 SDSQAKPVRFHFAEANSASPTGDGAVAHMLAALLDAIESHYGWLATRLYRAFRPKCLKVD 810
            ....:...|:|    :||.|.||.    :..|..|.:|:....||.:|::    :|.:|:
Human   488 RKMTSAIARWH----SSARPPGDA----LELAYADRLEAEMQELAIQLHK----RCEEVE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	22/63 (35%)
		Ank_2	173..266	CDD:289560	10/40 (25%)
		ANK repeat	205..233	CDD:293786	2/6 (33%)
		ANK	231..355	CDD:238125	33/124 (27%)
		ANK repeat	235..266	CDD:293786	6/31 (19%)
		Ank_2	240..332	CDD:289560	23/92 (25%)
		ANK repeat	268..299	CDD:293786	14/30 (47%)
		ANK repeat	301..332	CDD:293786	4/30 (13%)
		Ank_2	306..398	CDD:289560	24/91 (26%)
		ANK	329..454	CDD:238125	33/124 (27%)
		ANK repeat	334..362	CDD:293786	11/27 (41%)
		ANK repeat	367..398	CDD:293786	9/30 (30%)
		ANK repeat	400..431	CDD:293786	3/30 (10%)
		Ank_4	401..454	CDD:290365	11/52 (21%)
		ANK	428..553	CDD:238125	32/139 (23%)
		ANK repeat	435..464	CDD:293786	11/28 (39%)
		Ank_2	438..530	CDD:289560	28/106 (26%)
		ANK repeat	466..497	CDD:293786	12/44 (27%)
		ANK repeat	499..530	CDD:293786	7/31 (23%)
		Ank_5	518..575	CDD:290568	11/60 (18%)
		KAP_NTPase	605..1136	CDD:284995	44/246 (18%)
		SAM_superfamily	1357..1392	CDD:188886
ANKS3	XP_011520674.1	Ank_2	51..144	CDD:289560	34/125 (27%)
		ANK repeat	51..78	CDD:293786	5/26 (19%)
		ANK	75..201	CDD:238125	49/190 (26%)
		ANK repeat	81..111	CDD:293786	17/62 (27%)
		ANK repeat	113..144	CDD:293786	11/30 (37%)
		Ank_2	118..211	CDD:289560	32/124 (26%)
		ANK repeat	146..176	CDD:293786	9/29 (31%)
		ANK repeat	180..211	CDD:293786	14/57 (25%)
		SAM	434..494	CDD:197735	12/76 (16%)
		SAM_ANKS3	436..499	CDD:188918	14/83 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D58543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920