DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42672 and Kidins220

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	XP_038967539.1	Gene:	Kidins220 / 116478	RGDID:	619949	Length:	1803	Species:	Rattus norvegicus

Alignment Length:	1610	Identity:	565/1610 - (35%)
Similarity:	843/1610 - (52%)	Gaps:	249/1610 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 ENATTVLMVVAGRGLTAFVREFLARGADVQAEDLDNWTALLCASRNGHLDVVQLLLDHGAEVEHR 265
            |...|.||:.|.:|....|:|.|..||:...|||||||||:.||:.||:.:|:.||..||.:|||
  Rat    41 ECGQTPLMLAAEQGNVEIVKELLKNGANCNLEDLDNWTALISASKEGHIHIVEELLKSGASLEHR 105

  Fly   266 DMGGWTSLMWAAYRGHTELVRLLLDKGADGNAHG-NYHLGALLWAAGRGYKDIVELLVQRGAKVN 329
            ||||||:||||.|:|.|::|.|||..||:.:..| .|.:..::||||||:.|||.||:|.|||||
  Rat   106 DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVN 170

  Fly   330 VGDKYGTTALVWACRRGNVEIVDTLLKAGANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNV 394
            ..||||||.||||.|:|::|.|..||..||:||..|..|.|.|:||..||:|..|..||::.|||
  Rat   171 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 235

  Fly   395 NALDKDGMTALCIASREGFQDIAASLIAAGAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHAD 459
            |..||||.|||.|||:||..:|...|:.||.|:||.||..||.||.||:.||..:|.|||:|:||
  Rat   236 NLTDKDGNTALMIASKEGHIEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 300

  Fly   460 VDIQGKDRKTAIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKA 524
            :||:|:|.|||:|.|||||:..:|:.:|..|||.|..||||:|||::|.:.||:|:|.||||:.|
  Rat   301 IDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 365

  Fly   525 KVTASDKRGDTCLHIAMRARSKTIVEALLRNPKHSQLLYRANKAGETPYNIDSLHQKTILGQVFG 589
            ||:|.||:|||.||:|:|.||:.:.|.||||||..:||||.|||||||||||..|||:||.|:||
  Rat   366 KVSAVDKKGDTPLHVAIRGRSRRLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFG 430

  Fly   590 ARRLNTNEDSEGMLGYELYSSALADVLSEPTLTTPITVGLYAKWGSGKSFLLNKLRDEMNNFARQ 654
            ||.|:..|....||||:||||||||:|||||:..||.|||||:|||||||||.||.|||..||.|
  Rat   431 ARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQ 495

  Fly   655 WAEPPIRTSGLLFIVCLHVALLIG--TIVGLSTWSAVVGVSAAVGFLLLAYLLLAAVRYCNYQ-- 715
            ..||..:.|.|:..:.|   ||.|  .:|...|....:.::.::.||.|.|:....:.:...:
  Rat   496 QTEPLFQFSWLIVFLTL---LLCGGLGLVFAFTVDTNLAIAISLSFLALIYIFFIVIYFGGRREG 557

  Fly   716 MDMQWAYSVQHGLEKRMTRLRLILQVAFCHPPG-PQSDSQAKPVRFHFAEANSASPT-GDGAVAH 778
            ....||:::...|.:.:..|.|:.::.|.:||. |:..::|.||||.|.:.|..|.. |:.::|.
  Rat   558 ESWNWAWALSTRLARHIGYLELLFKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAE 622

  Fly   779 MLAALLDAIESHYGWLATRLYRAFRPKCLKVDVGWRWRRMCCIPIVLIFELALVTVVTGISLTVA 843
            |:|.|.||.|..:|:|||||:|.||.:  :.....:|::.||:|..:||...:..::.||:|...
  Rat   623 MIATLSDACEREFGFLATRLFRVFRTE--ESQGKKKWKKTCCLPSFVIFLFIVGCIIAGITLLAI 685

  Fly   844 YFTFADEKEKEHILV--ALYVIAAVMGTLICTHLHVLAKVFVSLFTSHIRVLKRAV----RSSES 902
            :     ..:.:|:.|  .|..||:|:|.....:.....:|..||..|..:.|..|.    :....
  Rat   686 F-----RVDPKHLTVNAILISIASVVGLAFVLNCRTWWQVLDSLLNSQRKRLHSAASKLHKLKSE 745

  Fly   903 APLTMLGAEVAVMTDMVKCLDAFTNQQSRLVGVIDALDSCDTERILTLLNAVQTLLSSPNRPFVL 967
            ..:.:|..||.:|..|.|.:|:||..|:|||.:||.||:|:.:::|.:|:.|:.|.|  ..||:.
  Rat   746 GFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFS--KGPFIA 808

  Fly   968 LISVDPHVIAKAAEANSRRLFTEGGIGGHDFLRNLVHLPVYLQNSGLRKVQRAQMTALLFKRSGG 1032
            :.:.|||:|.||...|...:..:..|.|||::||:|||||:|.:.||...::..:|:     :..
  Rat   809 IFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTS-----ATN 868

  Fly  1033 GDYQTDDGPTLG-HSVSARRLSNASEIISSQEKLRGPARGGGGKKLRLSESVASSTGSNLHRLGQ 1096
            ||....|  |.| ...:.||:|..|  :....||        |.|..|:.       .:.:|..|
  Rat   869 GDITCSD--TTGTQEDTDRRVSQNS--LGEMTKL--------GSKTALNR-------RDTYRRRQ 914

  Fly  1097 NPQTV-----LDLSRIVLTDDYFSDVNPRSMRRLMNVIYITVRLLKAFQIEFSWYRLSSWINLTE 1156
            ..:|:     .||:::::|:|:|||::|::||||:|::.:|.|||:|.||.|:|.||:|||||||
  Rat   915 MQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQITFNWDRLASWINLTE 979

  Fly  1157 QWPLRASMIVLHHDQFMDSNADESVSLQSVYEKLRPKLAYLREAAPLLELDRDERKLDAFLQLHK 1221
            |||.|.|.::|:.::  .....:.::|:::||::...:...::..||||:|.|.|..:.||....
  Rat   980 QWPYRTSWLILYLEE--TEGLPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRT 1042

  Fly  1222 SDLLVADLRIFLPFTINLDPYLRKVLKEDQQTIE--DEGSLVIQARPSVSNTMRQFPAPTTY--- 1281
            ..|:..|::.|||.|:||||.||:::.:.:...|  :.|.|.....|......|   .|:.|
  Rat  1043 PVLVARDVKTFLPCTVNLDPKLREIIADVRAAREQINIGGLAYPPLPLHEGPPR---PPSGYSQP 1104

  Fly  1282 ----------------VPSPQA--------------------YPPYQMFQNEYP--ANELRSRN- 1307
                            |.|||.                    :.||......||  :..|.||:
  Rat  1105 ASVCSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRSS 1169

  Fly  1308 ------------LSTSTEPVTPLINSPSDS----------------------------------F 1326
                        |...||.....:.||:||                                  .
  Rat  1170 VKTSLPRDQNNGLEVITEDAAEGLPSPTDSSRERSWTRKQMMQPCDSGFNKQRQVQKLQATVPAT 1234

  Fly  1327 GDDILQTKLTDLTVEGVISLLDRIEDM-KPALPKLAPVLRENAINGRVLKHCDMPDLKSVLGLSF 1390
            |..:|   |:.:||:.|...|.:||.: :..:|:....:::..||||||..|::.:||..:.::|
  Rat  1235 GSSLL---LSSMTVDVVCEKLRQIEGLDQSMMPQYCTTIKKANINGRVLSQCNIDELKKEMAMNF 1296

  Fly  1391 GHWELFRLLITTLRECERLPRKQQRQQQQPGALEAPSNVPMIK------------DVTDALMQPP 1443
            |.|.|||.::..:|..|     .|...:.|..|...|:.|:..            .:|:...|.|
  Rat  1297 GDWHLFRSMVLEMRSVE-----SQVVPEDPRFLNENSSAPVPHGESARRSSHTELPLTELSSQTP 1356

  Fly  1444 ---------------------RESLS------RKNSVSHMEKQ-VTLEEQMICGTLQTLNEEAYE 1480
                                 ..:||      |..|:|.:..| .::|...:...:|....:||.
  Rat  1357 YTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYR 1421

  Fly  1481 DVAS--------------SERPSPTE---LDTPSAGAAMTTPL---LGASGSVPAPSGRESILKQ 1525
            :..:              |.|.||..   :...|:|.::.:.|   .|..|.:....||:|.|.:
  Rat  1422 EYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSTLEQERGKEGELKQEDGRKSFLMK 1486

  Fly  1526 QGSVKADKRVSIQQMATSNNNNNNSTKLTPNVEYVSERQPEVQGAGKRLTTKPPPGPRPASLIIT 1590
            :|.|        ...::|..:.|.::.|.|    ::|...:...:|.:|........||
  Rat  1487 RGDV--------IDYSSSGVSTNEASPLDP----ITEEDEKSDQSGSKLLPGKKSSERP------ 1533

  Fly  1591 RNDSNSQFQL---LRSSSVDYDDVEAQEHRT----TIRTTLLEQQEEEES 1633
                 |.||.   |:...:.|..:.:.|..:    :..|.||:..:::::
  Rat  1534 -----SLFQTDLKLKGGGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKA 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	47/87 (54%)
		Ank_2	173..266	CDD:289560	31/64 (48%)
		ANK repeat	205..233	CDD:293786	10/27 (37%)
		ANK	231..355	CDD:238125	73/124 (59%)
		ANK repeat	235..266	CDD:293786	17/30 (57%)
		Ank_2	240..332	CDD:289560	51/92 (55%)
		ANK repeat	268..299	CDD:293786	17/30 (57%)
		ANK repeat	301..332	CDD:293786	18/30 (60%)
		Ank_2	306..398	CDD:289560	53/91 (58%)
		ANK	329..454	CDD:238125	68/124 (55%)
		ANK repeat	334..362	CDD:293786	16/27 (59%)
		ANK repeat	367..398	CDD:293786	15/30 (50%)
		ANK repeat	400..431	CDD:293786	17/30 (57%)
		Ank_4	401..454	CDD:290365	28/52 (54%)
		ANK	428..553	CDD:238125	70/124 (56%)
		ANK repeat	435..464	CDD:293786	17/28 (61%)
		Ank_2	438..530	CDD:289560	52/91 (57%)
		ANK repeat	466..497	CDD:293786	16/30 (53%)
		ANK repeat	499..530	CDD:293786	18/30 (60%)
		Ank_5	518..575	CDD:290568	38/56 (68%)
		KAP_NTPase	605..1136	CDD:284995	187/548 (34%)
		SAM_superfamily	1357..1392	CDD:188886	11/34 (32%)
Kidins220	XP_038967539.1	ANK repeat	43..73	CDD:293786	10/29 (34%)
		PHA02874	54..>383	CDD:165205	184/328 (56%)
		ANK repeat	75..106	CDD:293786	17/30 (57%)
		ANK repeat	108..137	CDD:293786	17/28 (61%)
		ANK repeat	175..203	CDD:293786	16/27 (59%)
		ANK repeat	241..272	CDD:293786	17/30 (57%)
		ANK repeat	274..304	CDD:293786	16/29 (55%)
		ANK repeat	307..371	CDD:293786	36/63 (57%)
		PHA02736	<354..418	CDD:165103	42/63 (67%)
		KAP_NTPase	446..959	CDD:284995	187/548 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14254
Inparanoid	1	1.050	883	1.000	Inparanoid score	I379
OMA	1	1.010	-	-		QHG46561
OrthoDB	1	1.010	-	-		D38210at33208
OrthoFinder	1	1.000	-	-		FOG0006003
OrthoInspector	1	1.000	-	-		oto96287
orthoMCL	1	0.900	-	-		OOG6_106563
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4301
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.880