DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42672 and kidins220

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	XP_012818173.1	Gene:	kidins220 / 100145198	XenbaseID:	XB-GENE-5839632	Length:	1764	Species:	Xenopus tropicalis

Alignment Length:	1616	Identity:	577/1616 - (35%)
Similarity:	882/1616 - (54%)	Gaps:	217/1616 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 MGSLGHRALLQYIDNNDISGLRAILDSRHLTIDDRDENATTVLMVVAGRGLTAFVREFLARGADV 229
            |..||.:.||.|::..:|:.|:.:|: :...:|:|:||..|.||:.|.:|....|:|.|...|:.
Frog     1 MAGLGPQNLLAYVEEGNIAALKTLLE-KCKDVDERNENGQTALMLAAEQGNLEIVQELLRNRANC 64

  Fly   230 QAEDLDNWTALLCASRNGHLDVVQLLLDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGAD 294
            ..||:||||||:.|::.|||::|:.||.:.|.:|||||||||:|:||:|:|..::|.|||.|||:
Frog    65 NLEDVDNWTALISAAKEGHLEIVRELLSYNANLEHRDMGGWTALIWASYKGSIDVVDLLLSKGAN 129

  Fly   295 GNAHG-NYHLGALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAG 358
            .|..| .|.:..::||||||:.|||:||:|.|||||..||:|||.|:||.|:|::|.|..||:.|
Frog   130 PNITGLQYSVYPVIWAAGRGHSDIVKLLLQYGAKVNCSDKFGTTPLIWAARKGHLECVKYLLQMG 194

  Fly   359 ANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAASLIAA 423
            |:||..|..|.|.|:||..||:||.|..||::.||||..||||.|||.||::||..:|...|:.|
Frog   195 ADVDQEGANSITALIVAVKGGYTDTVKEILKRNPNVNLTDKDGNTALTIAAKEGHTEIVQDLLDA 259

  Fly   424 GAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLA 488
            |.|:||.||..||.||.||:.||..:|.|||.|:||:||:|:|.|||:|.|||||:..:|:.:|.
Frog   260 GTYVNIPDRNGDTVLIGAVRGGHVEIVRALLNKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 324

  Fly   489 TNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALL 553
            .|||.|.:||||:|||::|.:.|::|:|.||||:.|||:|.||:|||.||||:|.||:.:.|.||
Frog   325 CNPDTEFSTKDGETPLIKATKMRSIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 389

  Fly   554 RNPKHSQLLYRANKAGETPYNIDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSE 618
            ||||..:||||.|||||||||||..|||:||.|:||||.|:..|....||||:||||||||:|||
Frog   390 RNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTESDGDMLGYDLYSSALADILSE 454

  Fly   619 PTLTTPITVGLYAKWGSGKSFLLNKLRDEMNNFARQWAEPPIRTSGLLFIVCLHVALLIGTIVGL 683
            ||:..||.|||||:|||||||||.||.|||..||.|..||..:.|.|:..:.|.:...||.::..
Frog   455 PTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLILMLCSTIGLLLSF 519

  Fly   684 STWSAVVGVSAAVGFLLLAYLLLAAVRYCNYQ--MDMQWAYSVQHGLEKRMTRLRLILQVAFCHP 746
             |....:|:|.|:..|.:.|:..|||.:...:  .:..||:.:...|.:::..|.|:|::.|.:|
Frog   520 -TVDPKLGISVALSLLTVLYIFFAAVYFGGRREGENWNWAWVLSTRLARQIGYLELLLKLMFVNP 583

  Fly   747 PG-PQSDSQAKPVRFHFAEANSASPT-GDGAVAHMLAALLDAIESHYGWLATRLYRAFRPKCLKV 809
            |. |:..::|.||||.|.:.|..|.. |:.::|.|:|.|.||.|..:|:|||||:|.|:.:  :.
Frog   584 PELPEQTTKALPVRFLFTDYNRLSSVGGETSMAEMIATLSDACEREFGFLATRLFRVFKTE--ET 646

  Fly   810 DVGWRWRRMCCIPIVLIFELALVTVVTGISLTVAYFTFADEKEKEHILVALYVIAAVMGTLICTH 874
            ....:|::.||:|..:||...::.:..|:.|...:...........||:|   :|.|:|.:...:
Frog   647 QGKKKWKKTCCLPSFVIFIFIMLCIFAGVLLLAIFKVDPKNMTVNAILIA---VACVVGLVFVLN 708

  Fly   875 LHVLAKVFVSLFTSHIRVLKRAV----RSSESAPLTMLGAEVAVMTDMVKCLDAFTNQQSRLVGV 935
            .....:|..|:..|..:.|..|.    :......:.:|..||.:|..|.|.:|:||..|:|||.:
Frog   709 CRTWWQVMDSILNSQRKRLHGAASKLHKLKSEGFMKVLKWEVELMAKMAKTIDSFTQNQTRLVVI 773

  Fly   936 IDALDSCDTERILTLLNAVQTLLSSPNRPFVLLISVDPHVIAKAAEANSRRLFTEGGIGGHDFLR 1000
            ||.||:|:.:::|.:|:.|:.|.|  ..||:.:.:.|||:|.||...|...:..:..|.|||::|
Frog   774 IDGLDACEQDKVLHMLDTVRILFS--KGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMR 836

  Fly  1001 NLVHLPVYLQNSGLRKVQRAQMTALLFKRSGGGDYQTDDGPTLGHSVSARRLSNASEIISSQEKL 1065
            |:|||||:|.:.||...::     |....:..||....:..:.||....||:|..|  ::...||
Frog   837 NIVHLPVFLNSRGLSNAKK-----LCSISATNGDVGCMESGSGGHEDLDRRVSQHS--LAEASKL 894

  Fly  1066 RGPARGGGGKKLRLSESVASSTGSNLHRLGQNPQTV-----LDLSRIVLTDDYFSDVNPRSMRRL 1125
                    |.|..|:.       .:.:|..|..:|:     .||:::::|:|:|||::|::||||
Frog   895 --------GSKTALNR-------RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRL 944

  Fly  1126 MNVIYITVRLLKAFQIEFSWYRLSSWINLTEQWPLRASMIVLHHDQFMDSNADESVSLQSVYEKL 1190
            :|::.:|.|||:|.||.|.|.||:||||||||||.|.|.::|:.:: .:...|:| :|:::||::
Frog   945 LNIVSVTGRLLRANQISFHWDRLASWINLTEQWPYRTSWLILYLEE-TEGVPDQS-TLKTIYERI 1007

  Fly  1191 RPKLAYLREAAPLLELDRDERKLDAFLQLHKSDLLVADLRIFLPFTINLDPYLRKVLKE-----D 1250
            ...:...::..||||:|.|.|..:.||......|:..|::.|||.|:||||.||:::.:     |
Frog  1008 SKNIPTTKDVEPLLEIDSDIRSFEVFLASRTPVLIARDVKTFLPCTVNLDPKLREIIADVRAARD 1072

  Fly  1251 QQTIEDEG-----SLVIQ-ARPSVSNTMRQ-------------FPA-------PTTYVP------ 1283
            |..|   |     :|.:| |.|..::...|             |||       |::|..
Frog  1073 QMNI---GGFPYPTLPLQDAPPRATSVFSQPSSVCSSSSFNGPFPAGVMSPQPPSSYYSGMTGPQ 1134

  Fly  1284 ---------SPQAYPPYQMFQN-EYPANE-------LRSRN--LSTSTEPVTPLINSPSDSFGDD 1329
                     :|..|.|...|.| ::|.:.       .|.:|  ||...|.....::||..:|
Frog  1135 HPFYNRPFFAPHVYLPRYYFGNPQHPMSRPSFKHSVSRDQNNGLSIIEEDAAETLSSPIRAF--- 1196

  Fly  1330 ILQTK----------LTDLTVEGVISLLDRIEDMKPA-LPKLAPVLRENAINGRVLKHCDMPDLK 1383
             |.|.          |..:.|:||...|..|:.::.: ||:....:|:..||||||..|.|.:||
Frog  1197 -LATSSSVAGAHSSALAAMNVDGVCEKLKGIDGIEQSMLPQYTATIRKANINGRVLTQCTMDELK 1260

  Fly  1384 SVLGLSFGHWELFRLLITTLRECERLPRKQQRQQQQPGALEAPSNVPMIKDVTD---ALMQPPRE 1445
            ..:.::||.|.||:..:..:|..:     .|.|.::...:..||.:....:||.   |..:.|..
Frog  1261 KEMNMNFGDWHLFKSALHEMRSSD-----TQIQPEEGRMVGEPSRMAPRSEVTRRPVATTELPHT 1320

  Fly  1446 SLSRKNSVSHMEKQVTLEEQMICGTLQTLN-EEAYEDVASSER----PSPTELDTPSAGAAMT-- 1503
            .|:.:|    .:...:.|:      |.||. ||:..::|...|    ||.:.:::..:...:|
Frog  1321 ELAGQN----YDFSFSFED------LNTLGFEESNRNMAWQGRAHRTPSLSSINSQESSNEITRL 1375

  Fly  1504 ----------------TPLLGASGSVPAPSGRESILK------------------------QQGS 1528
                            :.:....|:|.:.|||.|.|.                        :.|.
Frog  1376 TDKVQAEYRDAYREYISQMSQIEGAVSSVSGRSSPLSSGGYYIGQSTSVSSIHSASEQDKMKDGE 1440

  Fly  1529 VKAD--------KRVSIQQMATSNNNNNNSTKLTPNVEYVSERQPEVQGAGKRLTTKPPPGPRPA 1585
            :|.:        ||..:....:|..:..:::.|.|..|   |.:...|...|.|:||.|.
Frog  1441 LKHEEGRKPFLMKRTDVVDYTSSTVSTTDASPLDPITE---EDEKSDQSGSKLLSTKKPA----- 1497

  Fly  1586 SLIITRNDSNSQFQL----LRSSSVDYDDVEAQEHRT----TIRTTLLEQQEEEES 1633
                   :.:|.||.    |:.:.:.|..:.:.|..:    :..|.||:..:|:::
Frog  1498 -------ERSSLFQATDLKLKGTGLRYQKLPSDEDESGTEESDNTPLLKDGKEKKT 1546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	52/119 (44%)
		Ank_2	173..266	CDD:289560	37/92 (40%)
		ANK repeat	205..233	CDD:293786	9/27 (33%)
		ANK	231..355	CDD:238125	69/124 (56%)
		ANK repeat	235..266	CDD:293786	16/30 (53%)
		Ank_2	240..332	CDD:289560	50/92 (54%)
		ANK repeat	268..299	CDD:293786	17/30 (57%)
		ANK repeat	301..332	CDD:293786	18/30 (60%)
		Ank_2	306..398	CDD:289560	52/91 (57%)
		ANK	329..454	CDD:238125	66/124 (53%)
		ANK repeat	334..362	CDD:293786	14/27 (52%)
		ANK repeat	367..398	CDD:293786	16/30 (53%)
		ANK repeat	400..431	CDD:293786	16/30 (53%)
		Ank_4	401..454	CDD:290365	27/52 (52%)
		ANK	428..553	CDD:238125	70/124 (56%)
		ANK repeat	435..464	CDD:293786	17/28 (61%)
		Ank_2	438..530	CDD:289560	51/91 (56%)
		ANK repeat	466..497	CDD:293786	16/30 (53%)
		ANK repeat	499..530	CDD:293786	17/30 (57%)
		Ank_5	518..575	CDD:290568	39/56 (70%)
		KAP_NTPase	605..1136	CDD:284995	185/543 (34%)
		SAM_superfamily	1357..1392	CDD:188886	14/34 (41%)
kidins220	XP_012818173.1	Ank_4	9..58	CDD:290365	17/49 (35%)
		ANK	32..191	CDD:238125	82/158 (52%)
		ANK repeat	37..68	CDD:293786	10/30 (33%)
		Ank_2	42..133	CDD:289560	46/90 (51%)
		ANK repeat	70..101	CDD:293786	16/30 (53%)
		ANK repeat	104..134	CDD:293786	16/29 (55%)
		ANK repeat	137..168	CDD:293786	18/30 (60%)
		Ank_2	143..234	CDD:289560	52/90 (58%)
		ANK	165..290	CDD:238125	66/124 (53%)
		ANK repeat	170..198	CDD:293786	14/27 (52%)
		Ank_2	208..299	CDD:289560	50/90 (56%)
		ANK	231..356	CDD:238125	67/124 (54%)
		ANK repeat	236..267	CDD:293786	16/30 (53%)
		ANK repeat	269..299	CDD:293786	16/29 (55%)
		ANK repeat	302..366	CDD:293786	35/63 (56%)
		Ank_2	307..394	CDD:289560	49/86 (57%)
		KAP_NTPase	441..955	CDD:284995	185/543 (34%)
		SAM_superfamily	1215..1281	CDD:301707	23/65 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14254
Inparanoid	1	1.050	886	1.000	Inparanoid score	I391
OMA	1	1.010	-	-		QHG46561
OrthoDB	1	1.010	-	-		D38210at33208
OrthoFinder	1	1.000	-	-		FOG0006003
OrthoInspector	1	1.000	-	-		oto103010
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980