DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42672 and anks3

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_001108037.1	Gene:	anks3 / 100136846	ZFINID:	ZDB-GENE-080204-51	Length:	622	Species:	Danio rerio

Alignment Length:	627	Identity:	155/627 - (24%)
Similarity:	247/627 - (39%)	Gaps:	115/627 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 GADVQAEDLDNWTALLCASRNGHLDVVQLLLDHG-AEVEHRDMGGWTSLMWAAYRGHTELVRLLL 289
            ||.:..|:|:....|..|...|..|||...:..| .:::.:::||||.||:|||.||..:..|||
Zfish    28 GALIGPEELNVPLDLHTACSIGQYDVVSECIRRGDVDLDGQNIGGWTPLMYAAYIGHDNIANLLL 92

  Fly   290 DKGADGNAHGNYHLGALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTL 354
            :.|.:.||..:..|..|:.||..|.:.|...|:|:||::...|..|.|||:::...|:.::|..|
Zfish    93 ETGVNVNATTSKGLTPLMLAASCGNESIAHFLLQKGAQLECKDVRGWTALLYSTATGHQQMVKFL 157

  Fly   355 LKAGANVDTAGMYS-WTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAA 418
            |:..||.:.....| :|||:.|||.||...|..:|.........:..|.||..:|...|...| |
Zfish   158 LEHHANANVKEPLSGFTPLMEAAASGHEIIVQYLLSHGARTEDRNMKGETARALAMMYGHIKI-A 221

  Fly   419 SLI-------AAGAYINIQDRGADTPLIHAVKAGHRT-------VVEALLK-----KH------- 457
            |||       .:..|..:.....:.|......|..||       ..:|:.:     ||
Zfish   222 SLIDMHVIRAKSSMYEELSSSEEENPSPRVRSAHSRTRGPSIHDGPQAIARFRVGSKHEVPAAPP 286

  Fly   458 -----ADVDIQGKDRKTAIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPLLRAVRNRNLEIVH 517
                 .||..|.:.......|      :||.:|...:|...:....|.|.|.|::..:.:..:.|
Zfish   287 GYVTFRDVGDQSEGICNRDVT------SPINELDGQSNSSRDELFFDNDMPTLKSSSSSSESLSH 345

  Fly   518 LL-LDRKAKVTA---SDKRGDTCLHIAMRARSKTIVEALLRNPKHSQ--LLYR--ANKAGETPYN 574
            || |.|:|.:.:   ||:...:|     ..||..:..:..|:|.:|:  ..||  .:.:|..|..
Zfish   346 LLGLSREASLESNEDSDQAKRSC-----PRRSNKLQHSKSRSPYNSRGSAGYREVRSSSGPPPSY 405

  Fly   575 IDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSE--PTLTTP---ITVGLYAKWG 634
            .........|.|:..::.|...|:.:  :...::.:...:.|.|  .||..|   :|..: |:|.
Zfish   406 TGPKDLSEFLEQIGFSKYLPLLEEQD--IDLRIFLTLTENDLKEIGITLFGPKRRMTSAI-ARWH 467

  Fly   635 SG--------KSFLLNKLRDEMNNFARQWAEPPIRTSGLLFIVCLHVALLIGTIVGLSTWSAVVG 691
            |.        :....::|..||...|.|                ||              ...|.
Zfish   468 SNARPPSDALEQAYADQLEAEMQEMAIQ----------------LH--------------KRCVE 502

  Fly   692 VSAAVGFLLLAYLLLAAVRYCNYQMDMQWAYSVQHGLE---KRMTRLRLILQVAFCHPPGPQSDS 753
            |.:..|.:.....|.|.:..|..:..|.|. .||..|:   |||..|...|...      ..:.:
Zfish   503 VESFQGQVTQEKELRAVMEGCLMEEKMAWK-RVQAELQENAKRMQTLNAKLHTL------QNTHT 560

  Fly   754 QAKPVRFHFAEANSASPTGDGAVAHMLAALLDAIESHYGWLA 795
            |.|.:.   .:...:...|||.   |.:.||..:::|...||
Zfish   561 QLKQIT---QDDGRSVGKGDGL---MCSQLLTKMDTHIADLA 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	23/63 (37%)
		Ank_2	173..266	CDD:289560	11/40 (28%)
		ANK repeat	205..233	CDD:293786	2/6 (33%)
		ANK	231..355	CDD:238125	43/124 (35%)
		ANK repeat	235..266	CDD:293786	7/31 (23%)
		Ank_2	240..332	CDD:289560	34/92 (37%)
		ANK repeat	268..299	CDD:293786	17/30 (57%)
		ANK repeat	301..332	CDD:293786	10/30 (33%)
		Ank_2	306..398	CDD:289560	31/92 (34%)
		ANK	329..454	CDD:238125	38/139 (27%)
		ANK repeat	334..362	CDD:293786	10/27 (37%)
		ANK repeat	367..398	CDD:293786	11/31 (35%)
		ANK repeat	400..431	CDD:293786	11/37 (30%)
		Ank_4	401..454	CDD:290365	16/66 (24%)
		ANK	428..553	CDD:238125	30/152 (20%)
		ANK repeat	435..464	CDD:293786	9/52 (17%)
		Ank_2	438..530	CDD:289560	24/119 (20%)
		ANK repeat	466..497	CDD:293786	5/30 (17%)
		ANK repeat	499..530	CDD:293786	10/34 (29%)
		Ank_5	518..575	CDD:290568	17/64 (27%)
		KAP_NTPase	605..1136	CDD:284995	43/207 (21%)
		SAM_superfamily	1357..1392	CDD:188886
anks3	NP_001108037.1	Ank_2	42..135	CDD:289560	34/92 (37%)
		ANK repeat	42..69	CDD:293786	7/26 (27%)
		ANK	66..192	CDD:238125	48/125 (38%)
		ANK repeat	72..102	CDD:293786	16/29 (55%)
		ANK repeat	104..135	CDD:293786	10/30 (33%)
		Ank_2	109..202	CDD:289560	31/92 (34%)
		ANK repeat	137..167	CDD:293786	10/29 (34%)
		ANK repeat	171..202	CDD:293786	11/30 (37%)
		SAM	403..463	CDD:197735	11/61 (18%)
		SAM_ANKS3	405..468	CDD:188918	12/65 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D58543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920