Protein Alignment KCNA7 and Shawl

DIOPT Version :9

• Sequence 1: NP_114092.2
• Gene: KCNA7 / 3743
• HGNCID: 6226
• Length: 456
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 589
• Identity: 193/589 - (32%)
• Similarity: 259/589 - (43%)
• Gaps: 172/589 - (29%)

Human    14 RLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRL 78
            |::|||:|:|:||...||.:.|.|.|.........||....|||||||...|..:|.||::|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTG--- 67

Human    79 RRPAHVPLDV----FLEEVAFYGLGA---------------------AALARLR-EDEGCPVPPE 117
              ..|.|.||    |.||:.|:||.:                     |.|.:|. |:|   .|.|
  Fly    68 --KLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENE---KPTE 127

Human   118 RPLPR----------------RAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLP 166
            ..:.|                :....::|.:|:.|.||..|:::|.:||..|.||::.|||:|.|
  Fly   128 EQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHP 192

Human   167 DFRDD-RDGTGLAAAAAAGPFPAPLNGSSQMPGNPP----------------------------- 201
            .||.| ..|...|....||   .|.:|...| |.||
  Fly   193 GFRVDLPSGAHDAHGPGAG---GPPHGHDPM-GEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSY 253

Human   202 -----------------------RLPFN---------------------------------DPFF 210
                                   ||..|                                 :.||
  Fly   254 SSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFF 318

Human   211 VVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLA 275
            .||.:|..||..|:::||:|.|:...|.|:.:|:|||.|.|.::..:...:....|
  Fly   319 YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEYTG--------- 374

Human   276 ILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAE--VDRV 338
            :|....:||:.|:|||:|||.||:||..|.:||.:||.||:|||.:|:|.|:|..|:||  .|..
  Fly   375 LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNP 439

Human   339 DSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFY-H 402
            |:.|.|||...|||:||||||||||:||.|..|..||:|||:||||||:|||||||||||.|| |
  Fly   440 DNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSH 504

Human   403 RETEGEEAGMFSHV--------DMQPCGPLEGKANG---------GLVDGEVPELPPPLWAPP-G 449
            .:...:.......|        ..:|..|..|:.|.         |||.|.|  :|.....|. |
  Fly   505 TQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGV--VPVGAGGPGLG 567

Human   450 KHLV 453
            .|.|
  Fly   568 GHAV 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA7	NP_114092.2	BTB_2	15..105	CDD:280393	38/114 (33%)
		BTB	15..98	CDD:197585	34/86 (40%)
		Ion_trans	200..404	CDD:278921	105/291 (36%)
		Ion_trans_2	319..398	CDD:285168	51/80 (64%)
		Selectivity filter. /evidence=ECO:0000250	358..363		4/4 (100%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	36/96 (38%)
		BTB_2	7..97	CDD:280393	36/94 (38%)
		Ion_trans	307..506	CDD:278921	100/207 (48%)
		Ion_trans_2	<449..499	CDD:285168	37/49 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820