DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC12

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001380726.1	Gene:	ABCC12 / 94160	HGNCID:	14640	Length:	1359	Species:	Homo sapiens

Alignment Length:	1370	Identity:	449/1370 - (32%)
Similarity:	710/1370 - (51%)	Gaps:	164/1370 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFD-SESLTRNLQPHWEKESKKKNPS 77
            ||...|.::|...|.|:..|..||.|:.|....| ..|.::| |::..:..:..|::|..:..|.
Human    44 NPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTL-PPLSTYDSSDTNAKRFRVLWDEEVARVGPE 107

  Fly    78 LMRLIFKVYGWQF----VPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGI 138
            ...|...|  |:|    |.:.|:.::|.:.:.:..|.:|    .:....||..|....:   :||
Human   108 KASLSHVV--WKFQRTRVLMDIVANILCIIMAAIGPTVL----IHQILQQTERTSGKVW---VGI 163

  Fly   139 VLCSLVTSLVFHPFMFYVFA------VGTRVRLACAGLVYRKCLRASASSGEGLGGQAISVMSID 197
            .||..:.:..|....|:..|      ...|:::|.:.||:...:.....:...: |:.::::|.|
Human   164 GLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISV-GEVLNILSSD 227

  Fly   198 -LSQFDLTFYFFHDLWKGPVEACI---------FGYLMTRQVGWTSLIGIAFIVILIPLQAWAAK 252
             .|.|:...:.       |:.|.|         :.:.:   :|.|:||||:..||.||:|.:.||
Human   228 SYSLFEAALFC-------PLPATIPILMVFCAAYAFFI---LGPTALIGISVYVIFIPVQMFMAK 282

  Fly   253 ASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGS---MSIYA 314
            .:::|...:....|.||:.|||.:..|::||||||||||...|..:|:.|.|.:..:   .|..:
Human   283 LNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNS 347

  Fly   315 ALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSAR 379
            ||  ..::|.|::.|:|..::.:...:||...|.:.:.:.::..|:. ..|.:|...|:..||.|
Human   348 AL--APIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIA-ILPFSIKAMAEANVSLR 409

  Fly   380 RVVEFLLQVEKPTEESCCRD--------NPGLELDAE-----KPKPAQSGRLH-CVQSETKCLSF 430
            |:.:.|:....|:..:...|        |..|..:.|     .||..|:.:.| |.:..::..|.
Human   410 RMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSE 474

  Fly   431 RKVSASWDKPSIKQPRKPH---------IEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIEL 486
            |       .|..|....|.         :..|||.:..|:.:||.||||||||:||.|:||:::|
Human   475 R-------SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQL 532

  Fly   487 MQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVG 551
            .:|.|.|:|.::|.:||.|:|.|::||||||.|:|:.:||:..|..|.|.:||..||.||.|.:|
Human   533 QKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597

  Fly   552 ERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHV 616
            |||::|||||:.||:||||||....:||.||||:||||.|||.:.::|..:.|.||..:||||.:
Human   598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQL 662

  Fly   617 QLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAAL----------------DLEAIEADKQQVK 665
            |.|:|.|:::|||.|::.::|:::||.:....:|.|                :...:||.|:
Human   663 QFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKE--- 724

  Fly   666 RVLSQVDRTSKQ----LSKGEEKDPATIQDENGN-------AEQQL-------QGAVSYDTYKAY 712
               |..:|....    |:.|.|||... :.|.|:       .|.||       :|.|::.||..|
Human   725 ---SPAEREEDAGIIVLAPGNEKDEGK-ESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTY 785

  Fly   713 FRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVI------- 770
            .:|.|...|....:.:|:|..|..|..:.::..|.    |:|.......:..||...:
Human   786 IKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWL----DKGSRMTCGPQGNRTMCEVGAVLADI 846

  Fly   771 ------W-YTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNR 828
                  | ||..::..|...:.:.|.|....|..|.:|||.::..|:::.|.||:..|:||::||
Human   847 GQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNR 911

  Fly   829 FSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIV-AIANYWLLIPAAIMVILLYFCRALYIGASRS 892
            ||.|:..:||.||....:.||....||.:|||: |:....||:.|::.|......|..:.|. :.
Human   912 FSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGV-QE 975

  Fly   893 LKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQ--TFHGHQNTNSSALFLYVSANRAFSFW 955
            ||::|:::|||.::|...:..|...|.   |..:.|.  |:|         |..:..|.|.|:..
Human   976 LKKVENVSRSPWFTHITSSMQGLGIIH---AYGKKESCITYH---------LLYFNCALRWFALR 1028

  Fly   956 TDLICVI----YILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVER 1016
            .|::..|    ..|.||.||..|:.|    ..||:::..:.|..:.|..:|...|.:...||||.
Human  1029 MDVLMNILTFTVALLVTLSFSSISTS----SKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVEL 1089

  Fly  1017 VLEYAQTPSEPPLESPKSVNLA-AEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIV 1080
            :.||..| ..|....|..|... .:||..|.:.|:|.:|||......:|..||...|..:.:|||
Human  1090 LREYIST-CVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIV 1153

  Fly  1081 GRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPF 1144
            ||||:||||:..|||||. ...|||.||.:||..|.|.|||:::::||||||||.||:|:|||||
Human  1154 GRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPF 1218

  Fly  1145 DEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEA 1209
            :..:||.||..|:...::..:..|...|...:.:.|.|||:|:|||:|:|||:||.::::::|||
Human  1219 ESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEA 1283

  Fly  1210 TANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGA 1274
            ||::|::||.|:|.||:..|..||||||||||:||::.|.||||:.|:::||..|..|.::.|.|
Human  1284 TASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSA 1348

  Fly  1275 LLKLV 1279
            ...|:
Human  1349 FAMLL 1353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	445/1357 (33%)
		ABC_membrane	95..360	CDD:294371	71/283 (25%)
		ABCC_MRP_domain1	428..632	CDD:213217	100/212 (47%)
		ABC_membrane	728..994	CDD:294371	78/286 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	108/219 (49%)
ABCC12	NP_001380726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..491		11/51 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660