DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC10

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_016866934.1	Gene:	ABCC10 / 89845	HGNCID:	52	Length:	1558	Species:	Homo sapiens

Alignment Length:	1336	Identity:	428/1336 - (32%)
Similarity:	680/1336 - (50%)	Gaps:	152/1336 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ISKWLFLWMHSVFRKGR----REELDASKLYEHL-PSFDSESLTRNLQPHWEKESKKKNPSLMRL 81
            :|::.:.|:..:..:|.    |:..|..:|...| |::    |.|..|.||::.::     |.|.
Human   272 LSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTY----LARVFQAHWQEGAR-----LWRA 327

  Fly    82 IFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGIVLCSLVTS 146
            ::..:|..::.:.:| .|:...:....||||..|:.:...||..::  ...|||:|:...:::.:
Human   328 LYGAFGRCYLALGLL-KLVGTMLGFSGPLLLSLLVGFLEEGQEPLS--HGLLYALGLAGGAVLGA 389

  Fly   147 LVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLGGQAISVMSIDLSQFDLTFY-FFHD 210
            ::.:.:.:.|:.|..:.|.|...::|.|.|:...|...  .|:|::::..| |:..|.|. .||:
Human   390 VLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPP--TGEALNLLGTD-SERLLNFAGSFHE 451

  Fly   211 LWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEI 275
            .|..|::..|..||:.:|||...:.|:...::|:|:....|....:......:|:||||||:.|:
Human   452 AWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTEL 516

  Fly   276 IGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFLSLV---AYVYV 337
            :..|:|||...||::.|..:.|.|..|:..:|....:.||  |..:.:.:.:.:|:|   .||.:
Human   517 LSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAA--CVYLWAALPVVISIVIFITYVLM 579

  Fly   338 GDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPG 402
            |..:||.|||...:...:|...|.:: |..|....:..||..|:..|
Human   580 GHQLTATKVFTALALVRMLILPLNNF-PWVINGLLEAKVSLDRIQLF------------------ 625

  Fly   403 LELDAEKPKPAQS---GRLHCVQSETKC----------LSFRKVSASWDKPSIKQPRKPHIEGIS 454
            |:|....|:...|   |||........|          |.......|||      |....:|...
Human   626 LDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWD------PVGTSLETFI 684

  Fly   455 FH--INAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHG---RISYAAQQPWVFQGSIREN 514
            .|  :..|..|||||.||.|||:||.||.||:..::|.|.|.|   ....|.|:||:...:||:|
Human   685 SHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDN 749

  Fly   515 ILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYL 579
            |||.:.::.:.|:.|:.||.|:.||.:||.||.|.|||:|::|||||:||||||||||::.::||
Human   750 ILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYL 814

  Fly   580 FDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKD 644
            .|||||||||.|...|:.:|...:|....|:|.||..:.|:..|.:||:|.|:|.:.|...|:
Human   815 LDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEI-- 877

  Fly   645 VITHHAALDLEAIEADKQQVKRVLSQVDRTSKQLSKGEEKDPATIQDENGNA------EQQLQGA 703
                     |..::|..:.......:.|..:.|..:..||....:::|...:      |.:.:||
Human   878 ---------LPLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKEGA 933

  Fly   704 VSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKM 768
            |:...|:||::|:|....:.::.|: :|.:..:...|.::|.|.:..:............:...|
Human   934 VALHVYQAYWKAVGQGLALAILFSL-LLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASM 997

  Fly   769 VIWYTVLLL-----LTLALF-------------------------------LLRTFGFFFMCLRI 797
            .::...|||     |.:.:|                               |||...|....|:.
Human   998 GLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQA 1062

  Fly   798 SLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVA 862
            :.|||.:|.|.::.|.:.||||.|:||:|||||||:...|.:||..:...|.....::.:|.::.
Human  1063 AATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLG 1127

  Fly   863 IANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQL 927
            ....|||:....:.|:.|..:..|..:||.|:|:.|||.||:|||...|..|.|.:|:..|..:.
Human  1128 SGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRF 1192

  Fly   928 EQTFHGHQNTNSSALFLYVSANRAFSFWTD----LICVIYILAVTFSFLVINQSFYS--GDVGLA 986
            |:........|....|    |..|...|.|    |:....:.|:....||.:|...:  |.|||:
Human  1193 EEENLRLLELNQRCQF----ATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLS 1253

  Fly   987 ITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEY-AQTPSEP---PLESPKSVNLAAEWPQAGHL 1047
            ::.:::|..:....:....:.|..:.||||:.|| ...|.||   ||:      |...|...|.:
Human  1254 LSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQ------LGTGWLTQGGV 1312

  Fly  1048 RFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTIEIDGLDI 1111
            .|||:.:.|.||..:.|.|:.|..||.||:|||||||:||||::..||| |..:.|.:.:||:|.
Human  1313 EFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDT 1377

  Fly  1112 GKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRM 1176
            .:|.|..|||:::||||:|.|||||:|.||||.....|.:||.||....|.:.:.|: |||...:
Human  1378 SQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGEL 1441

  Fly  1177 QDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRL 1241
            .:||.:.|:|||||:|||||:|...::|.:|||||:||.:||.|:|:||..:||..|||||||||
Human  1442 GEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRL 1506

  Fly  1242 HTVMDNDSVLVMDAGQIVEFGA-------PHKLLQR 1270
            :|::::|.|||:.||::||..:       ||.|.|:
Human  1507 NTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQ 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	426/1332 (32%)
		ABC_membrane	95..360	CDD:294371	74/268 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	93/208 (45%)
		ABC_membrane	728..994	CDD:294371	79/307 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	111/226 (49%)
ABCC10	XP_016866934.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650