DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10505 and ABCC3

DIOPT Version :9

Sequence 1:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_003777.2 Gene:ABCC3 / 8714 HGNCID:54 Length:1527 Species:Homo sapiens


Alignment Length:1380 Identity:450/1380 - (32%)
Similarity:708/1380 - (51%) Gaps:184/1380 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSPKRESNPF--IKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEK 69
            |:...:.||:  ..|..:|:..|.|...:...|.|..|:...|:.......|:.:.:.|...|.|
Human   198 SAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRK 262

  Fly    70 ESKK----------------------------KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHS 106
            :.|:                            :.||.::.:...:|..|: :...:.|::..:..
Human   263 QEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFL-ISACFKLIQDLLSF 326

  Fly   107 FQPLLLGGLISYFA-------YGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVR 164
            ..|.||..||.:.:       :|         :|.|..:.|||::.||:...:..|:|..|.:.|
Human   327 INPQLLSILIRFISNPMAPSWWG---------FLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFR 382

  Fly   165 LACAGLVYRKCL-------RASASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFG 222
            ....|::|||.|       |||..      |:.:::||:|..:|.....|.:.||..|::..:..
Human   383 TGIMGVIYRKALVITNSVKRASTV------GEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAI 441

  Fly   223 YLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAW 287
            |.:.:.:|.:.|.|:||:|:||||....|....:|..:..|.:|:|:|||:||:..|:|:|:|||
Human   442 YFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAW 506

  Fly   288 EKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISK-ISLFLSLVAYVYV--GDLVTAKKVFIL 349
            |.||.:.:..:||.|::.:|.:..::.....|.|.|. :...::|..||||  .:::.|:|.|:.
Human   507 EPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVS 571

  Fly   350 SSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQ 414
            .|.:.:|. ..|:..|..|:...|..||.:|:.:||.|.|             |:..:.:.|...
Human   572 VSLFNILR-LPLNMLPQLISNLTQASVSLKRIQQFLSQEE-------------LDPQSVERKTIS 622

  Fly   415 SGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHA 479
            .|....:.|.|         .:|     .|...|.:..:...:..|..|.:||.||.|||:|:.|
Human   623 PGYAITIHSGT---------FTW-----AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSA 673

  Fly   480 ILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPR 544
            :|||:|.::|:|.:.|.::|..||.|:...:::||:||.:....|||:..:.||.|..|||:||.
Human   674 LLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPG 738

  Fly   545 GDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGK 607
            ||.|.:||:||:|||||:.|::||||||..|||:|.||||:|||:.|.|.:.|...  ..:|.||
Human   739 GDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGK 803

  Fly   608 MRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL------------------------------ 642
            .|:||||.:..|...|.:::|..|::::.|.|..|                              
Human   804 TRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 868

  Fly   643 -----------KDVITHHAAL----------------DLEAIEADKQ-QVKRVLSQVDRTSKQLS 679
                       :|.:::|..|                .|.|:.:|.: |.:.|..:....|:::.
Human   869 EGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQ 933

  Fly   680 KGEEK-DPATIQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFI 743
            ..|.| |.|..|:|....     |.|....:..|.:|:|    :|..|::.:|..| |:...|..
Human   934 VTEAKADGALTQEEKAAI-----GTVELSVFWDYAKAVG----LCTTLAICLLYVG-QSAAAIGA 988

  Fly   744 SRW-ATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYH 807
            :.| :.|..|...||..:..:.|..:   |..|.:|...|.:|.........::.:..||..|.|
Human   989 NVWLSAWTNDAMADSRQNNTSLRLGV---YAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLH 1050

  Fly   808 GIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIAN---YWLL 869
            ..||:...||:..||||:||.||.||..||..|...::..|....:.::.||::..:.   ..::
Human  1051 NKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVI 1115

  Fly   870 IPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGH 934
            :|.|::..|:   :..|...||.|||:||::|||||||.::|..|.|.||:.:.....|......
Human  1116 LPLAVLYTLV---QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTK 1177

  Fly   935 QNTNSSALFLYVSANRAFSFWTDLI--CVIYILAVTFSFLVINQSFYS-GDVGLAITQSMTLVIM 996
            .:.|..:.:.|:.:||..|...:.:  ||:...|:   |.||.:|..: |.|||:::.|:.:...
Human  1178 VDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAAL---FAVIGRSSLNPGLVGLSVSYSLQVTFA 1239

  Fly   997 CQWGMRQTAEMENNMTSVERVLEYAQTPSEPP--LESPKSVNLAAEWPQAGHLRFQDLRMRYSPG 1059
            ..|.:|..:::|:|:.:||||.||::|.:|.|  :|..:.   ...||..|.:.|::..:||.||
Human  1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRP---PEGWPPRGEVEFRNYSVRYRPG 1301

  Fly  1060 DEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTIEIDGLDIGKLGLHDLRSRI 1123
            .:.:||.|:......||:||||||||||||:...||| |...:|.|.||||::..:|||||||::
Human  1302 LDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQL 1366

  Fly  1124 SIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQR 1188
            :||||||:|||||||.|||||...|:|.:|.||:...|...|:|...||..:..:||.|.|:|||
Human  1367 TIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQR 1431

  Fly  1189 QLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVM 1253
            ||||||||:||::|:||:|||||.:|.|||.|||.||:|:|..||||||||||:|:||...|||:
Human  1432 QLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVL 1496

  Fly  1254 DAGQIVEFGAPHKLL 1268
            |.|.:.||.:|..|:
Human  1497 DKGVVAEFDSPANLI 1511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 448/1373 (33%)
ABC_membrane 95..360 CDD:294371 82/281 (29%)
ABCC_MRP_domain1 428..632 CDD:213217 84/205 (41%)
ABC_membrane 728..994 CDD:294371 80/272 (29%)
ABCC_MRP_domain2 1045..1264 CDD:213211 124/219 (57%)
ABCC3NP_003777.2 SunT 7..1526 CDD:331423 450/1380 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..932 4/21 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151513
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.660

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