DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and VMR1

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_011828.1	Gene:	VMR1 / 856350	SGDID:	S000001027	Length:	1592	Species:	Saccharomyces cerevisiae

Alignment Length:	1413	Identity:	411/1413 - (29%)
Similarity:	699/1413 - (49%)	Gaps:	211/1413 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSPKRESNPFIKANIISKWL--FLWMHSVFRKGRREELDASKLY----EHLPSFDSESLTRNLQP 65
            :||.||....|.:.|...|:  |:|      :.::..:....::    |....|..:..||
Yeast   264 TSPSREHISSILSCITWSWITNFIW------EAQKNTIKLKDIWGLSMEDYSIFILKGFTR---- 318

  Fly    66 HWEKESKKKNPSLMRLI--FKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAY-----GQ 123
                .:|..|...:.|.  ||.|        :|..:|.:.::|...||...|:..|..     .:
Yeast   319 ----RNKHINNLTLALFESFKTY--------LLIGMLWVLVNSIVNLLPTILMKRFLEIVDNPNR 371

  Fly   124 TTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLR-------ASAS 181
            ::.....|:||.:|:.:|.|..::......|....:..|:|....|.:|.|.||       .::|
Yeast   372 SSSCMNLAWLYIIGMFICRLTLAICNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSS 436

  Fly   182 SGEGLG---GQAISVMSID-LSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVI 242
            ..:.:.   |..|:::||| ....:|..|.:..:....:...:.| |:...:|.::..||:.|::
Yeast   437 DSDSISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVG-LLFNFLGVSAFAGISIILV 500

  Fly   243 LIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEV---- 303
            :.||....|.....|..::.|..|.|:..:||.:..|:::|.:|||::....|.::||.|:
Yeast   501 MFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLL 565

  Fly   304 -KAIRGSMSIYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMA 367
             |::..|::.:.......:::.::  .::..:|...|| .|...|...|.:.||...|.....|
Yeast   566 KKSLVWSVTSFLWFVTPTLVTGVT--FAICTFVQHEDL-NAPLAFTTLSLFTLLKTPLDQLSNM- 626

  Fly   368 ITTWAQTLVSARRVVEFLL--QVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSF 430
            ::...|:.||.:|:.:||.  ..||..:         |.:..:|.|                :.|
Yeast   627 LSFINQSKVSLKRISDFLRMDDTEKYNQ---------LTISPDKNK----------------IEF 666

  Fly   431 RKVSASW-----DKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGR 490
            :..:.:|     |..:.|      :.|::.....|:...|:|:.|||||.||..:|||:.|:.|.
Yeast   667 KNATLTWNENDSDMNAFK------LCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGS 725

  Fly   491 VEV------HGRI----------SYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDL 539
            :.|      |..|          :|.:|..|:...:::.||:|...|.|.||..|:.||.|.|||
Yeast   726 IIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDL 790

  Fly   540 ELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF-HRL 603
            |:||.||.|.:||:||:||||||.||:||||||..|...|.||.|:|||:.....:.:.|. ..|
Yeast   791 EILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGPL 855

  Fly   604 LDGKMRILVTHHVQL-LKSVDQLLLLEGGKLTQQGSYEEL---------------KDVITHHAAL 652
            :..:..|||||:|.| |::....::||.||:..||:..||               :|.|....|.
Yeast   856 MKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGLFKEKYVQLSSRDSINEKNAN 920

  Fly   653 DLEA-IEADKQQVKRVLSQVDRTSKQLSKGEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRAL 716
            .|:| .:.|.|:::.|...::..:..::.|:     .|::     |::..||:|.|.||.|.:..
Yeast   921 RLKAPRKNDSQKIEPVTENINFDANFVNDGQ-----LIEE-----EEKSNGAISPDVYKWYLKFF 975

  Fly   717 GAPFLVCLVLSMFVLARGCQAVMDIFISR--WAT-WEEDR-------GY-------DSVDDYEAT 764
            |....:..:.::::.|:      .:|||:  |.. |..|.       |:       ..:.|....
Yeast   976 GGFKALTALFALYITAQ------ILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKN 1034

  Fly   765 RTKMVIWYTVLLLLTLALFLL---RTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVL 826
            :.....:.||..|:.:...:|   :|...|...:|.|..:.:.|...::.|.:.||:..|.||::
Yeast  1035 KHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIM 1099

  Fly   827 NRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASR 891
            ||||.||:.||..|...:..::..|:...:::.::.:.....|..|.|:.:|.:|....|:.|||
Yeast  1100 NRFSKDIEGVDQELIPYLEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASR 1164

  Fly   892 SLKRIESLTRSPIYSHTNQTFHGHSTIRS--------MDAMPQLEQTFHGHQNTNSSALFLYVSA 948
            .|||::|:|:|||:.|.::|..|..|||:        ::.|.:::|        |:.| |.|:|.
Yeast  1165 ELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQ--------NNRA-FFYLSV 1220

  Fly   949 N-RAFSFWTDLICVIYILAVTFSFLVIN-QSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNM 1011
            . :.|||..|:|....:|| :.||:::| .:..||..|:::|.::.......|.:|..:..|.||
Yeast  1221 TVKWFSFRVDMIGAFIVLA-SGSFILLNIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNM 1284

  Fly  1012 TSVERVLEYAQTPSEPPLESPKS-VNLAAE--WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQP 1073
            .||||:.||:....|..|...:. :.|..|  ||:.|.:..::|.:||:|....::|.::|:..|
Yeast  1285 NSVERLKEYSSIEQENYLGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNLPPVIRNVSFKVDP 1349

  Fly  1074 MEKIGIVGRTGAGKSSIIQALFRLALN-EGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTL 1137
            ..|||||||||||||:||.|||||... .|.|:|||.||.|:.|..||..|:||||||:||:||:
Yeast  1350 QSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTI 1414

  Fly  1138 RFNLDPFDEKSDESLWSALDDVKLKKHVASLEG------------------GLSCRMQDGGSNFS 1184
            :.|:||:||..::.::.||..|.|   ::|.|.                  .|...:.:||.|.|
Yeast  1415 KSNVDPYDEYDEKKIFKALSQVNL---ISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLS 1476

  Fly  1185 MGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDS 1249
            .|:|||:.:||::||:.:::::||||:::|.::|.|||..|:::|.:.|:|||||||.:|:|.|.
Yeast  1477 QGERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDR 1541

  Fly  1250 VLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFLKRIASES 1297
            ::|||||::.|:..|.:||:.:.|....:.  .|:..::.||:||.:|
Yeast  1542 IIVMDAGEVKEYDRPSELLKDERGIFYSMC--RDSGGLELLKQIAKQS 1587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	399/1377 (29%)
		ABC_membrane	95..360	CDD:294371	63/285 (22%)
		ABCC_MRP_domain1	428..632	CDD:213217	84/226 (37%)
		ABC_membrane	728..994	CDD:294371	78/295 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	102/237 (43%)
VMR1	NP_011828.1	MRP_assoc_pro	212..1575	CDD:188098	406/1399 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.640