DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10505 and YKR104W

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_013030.1	Gene:	YKR104W / 853979	SGDID:	S000001812	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	302	Identity:	123/302 - (40%)
Similarity:	172/302 - (56%)	Gaps:	44/302 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1011 MTSVERVLEYAQTPSE------PPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNF 1069
            |:||||:.||...|||      ||          |.|||.|.:..::|.:||||.....|..::|
Yeast     1 MSSVERIKEYTDIPSESNGYISPP----------ANWPQTGDVELKNLSLRYSPHSSKALDNVSF 55

  Fly  1070 ESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLF 1133
            :.:...|:||||||||||||||.|::||: ...|||.||..||..:.|..||:.||.|||||.||
Yeast    56 KVKAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLF 120

  Fly  1134 SGTLRFNLDPFDEKSDESLWSALDDV-----------------------KLKKHVASLEGGLSCR 1175
            .||:|.||||||..||..::..|..|                       ||:.....    |:..
Yeast   121 DGTVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFID----LNTV 181

  Fly  1176 MQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHR 1240
            ::.||||.|.|||||:||||::|....::::|||||::|..:|..||:||:......|:||||||
Yeast   182 VKSGGSNLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHR 246

  Fly  1241 LHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQN 1282
            |.:|:|.|.:|||:.|::.|:..|:.|:..::....:|..|:
Yeast   247 LRSVIDYDKILVMEMGRVKEYDHPYTLISDRNTIFYRLCRQS 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	120/286 (42%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217
		ABC_membrane	728..994	CDD:294371
		ABCC_MRP_domain2	1045..1264	CDD:213211	103/242 (43%)
YKR104W	NP_013030.1	ABCC_NFT1	27..270	CDD:213269	106/246 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830