DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and NFT1

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_013029.3	Gene:	NFT1 / 853978	SGDID:	S000001811	Length:	1218	Species:	Saccharomyces cerevisiae

Alignment Length:	1065	Identity:	270/1065 - (25%)
Similarity:	456/1065 - (42%)	Gaps:	246/1065 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 EKESKKKNPS-----------LMRLIFKVYG--------WQF----VPVCILYSLLEMAIHSFQP 109
            |.|:||..|:           :.|||:|.|.        |..    ..:.||.: .||:  |.:.
Yeast   236 ENENKKLPPAPTVFGLLTFSRIDRLIWKAYKHCLGNADIWDLDINNKSIAILAN-FEMS--SKKG 297

  Fly   110 LLLGGLISYFA---YGQTTVTKESAYLYAMGIVLCSLVTSLVFHP-------FMFYVFAV----- 159
            .||..:|.||.   ..|..:...|::|..:..:|...:.|.|..|       ...||.::
Yeast   298 RLLPNIICYFKAVFISQLFLAFVSSFLNFVPSLLMPRILSYVNDPKSKSWNLVSLYVSSMLVSKI 362

  Fly   160 ---------------GT-RVRLACAGLVYRKCLR--------------ASASSGEG--------- 185
                           || ::|......:|.|.||              ||.|..|.
Yeast   363 IATTCRGQGLFLGEKGTMQLRTVLISNIYSKTLRRTILKDSTTSLQKNASTSFEENPDSSEAEPR 427

  Fly   186 -----LGGQAISVMSID---LSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVI 242
                 ......:|||||   :|:...|||...:.....|.|.:..|.:   :||::..|...::.
Yeast   428 KKSSRKDNSVNNVMSIDAFKVSEAMNTFYLACEAVFMTVTALMILYSL---LGWSAFAGTFALLA 489

  Fly   243 LIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIR 307
            :|||..|.|....::........|.|...::|.:.:|:|||:.|||..|.:.|..||..|::.::
Yeast   490 MIPLNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLK 554

  Fly   308 GSMSIYAALQC-----TNMISKI--SLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWP 365
            ...:|:.....     ..::|.|  |:|:.     :....:|....|...|.:.:|..      |
Yeast   555 KKATIFFLNHLIWFFGPTLVSAITFSVFIK-----FQNQTLTPTIAFTALSLFAILRT------P 608

  Fly   366 M-----AITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSET 425
            |     .::...|:.:|..|:.::|       .||..|....||                 ||.|
Yeast   609 MDQIASTVSLLIQSFISLERIQDYL-------NESETRKYEILE-----------------QSNT 649

  Fly   426 KCLSFRKVSASWD--KPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQ 488
            | ..|...|..|:  :.|.|      ::.||..........|:|..|||||:||..:|||:.|:.
Yeast   650 K-FGFEDASMEWEAAETSFK------LKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLS 707

  Fly   489 GRVEV----------------HGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDR 537
            |::.|                ...::|.:|.||:..|:|::|::|.|.:.::::..|:.:|.||:
Yeast   708 GKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDK 772

  Fly   538 DLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF-H 601
            |::.:..|..|.||:.|.||||||:.|||||||:|..:...:.||.|:|||.:....:.::|. .
Yeast   773 DIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCG 837

  Fly   602 RLLDGKMRILVTHHVQLL-KSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLEAIEADKQQVK 665
            .::.|:..|:.:|::.|: |..|.|::|:.|::..||   :..|:|..:..| .|:|..|.:...
Yeast   838 PMMKGRTCIITSHNISLVTKRADWLVILDRGEVKSQG---KPSDLIKSNEFL-RESINNDSKNTT 898

  Fly   666 RVLSQVD----RTSKQLSKGEEKDPATIQDENGNA------------EQQLQGAVSYDTYK---A 711
            .  :|:|    .|||:...|   ||     |.||:            |.:::|:|.:..||   .
Yeast   899 H--NQIDLKRSTTSKKTKNG---DP-----EGGNSQDEVCAEVENFEETKMEGSVKFSAYKWLAD 953

  Fly   712 YFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW---------ATWEEDRGYDSVDDYEATRTK 767
            ||..||..|   :..|..:|..|.......::..|         :||.    |..|:.:    :.
Yeast   954 YFGGLGVVF---VFTSSSILIHGITLSQGFWLRYWLDTGSSGSKSTWL----YRIVEGH----SN 1007

  Fly   768 MVIWYTVLLLLTLALFLLRTFGFFFMCL----RISLTLHDQLYHGIIRAWMYFFNANPSGRVLNR 828
            :....|.:::..::.||  |.|..::.:    .::..:..:|...|:.|.:.|.|..|:||::||
Yeast  1008 IYFLLTYIIIGLVSSFL--TSGKVWIAIISGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNR 1070

  Fly   829 FSSDIQNVDVNLPQAMMDSLQFL-VDVVAVLVIVAIANY----WLLIPAAIMVILLYF--CRALY 886
            ||.|:..:|    |.::.:.:.| ..||..|.|:.:..|    :||.  ||.:..||:  | .||
Yeast  1071 FSKDMDIID----QQLIPNFEGLSYSVVVCLWIILLIGYVTPQFLLF--AIPLCALYYTVC-TLY 1128

  Fly   887 IGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSM-DAMPQLEQTFHGHQNTNSSALFLYVS-AN 949
            :.|||.||||:::..|||:....:...|.:|||:: |....:.|:......:|  |.|.|:: |.
Yeast  1129 LRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDRSN--APFFYLNMAT 1191

  Fly   950 RAFSFWTDLICVIYILAVTFSFLVI 974
            ...::..|:|..:    |.||..|:
Yeast  1192 EWITYRVDIIGTL----VLFSSSVM 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	270/1065 (25%)
		ABC_membrane	95..360	CDD:294371	74/333 (22%)
		ABCC_MRP_domain1	428..632	CDD:213217	70/223 (31%)
		ABC_membrane	728..994	CDD:294371	69/269 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	265/1049 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830