Protein Alignment CG10505 and STE6

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_012713.1
• Gene: STE6 / 853671
• SGDID: S000001692
• Length: 1290
• Species: Saccharomyces cerevisiae
• Alignment Length: 1369
• Identity: 301/1369 - (21%)
• Similarity: 541/1369 - (39%)
• Gaps: 336/1369 - (24%)

  Fly   135 AMGIV--LCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLGGQAISVMSID 197
            |.|:|  :.|::|..||.....:| |.|:.     .||..:...|:.|..  .||..::.||.:.
Yeast    36 ATGLVPAITSILTGRVFDLLSVFV-ANGSH-----QGLYSQLVQRSMAVM--ALGAASVPVMWLS 92

  Fly   198 LSQF-----------------------DLTFYFFHDLWKG---PVEACI----------FGYLMT 226
            |:.:                       .:.:|..::...|   .:..|:          ......
Yeast    93 LTSWMHIGERQGFRIRSQILEAYLEEKPMEWYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQ 157

  Fly   227 RQVGWTSLIGIAF-------IVILIP---LQAWAAKASASFGTRSAKHRDARVK---LMNEIIGA 278
            ..|...:|:|.:|       ::||..   :..:|...|......|.|......|   |:...:.|
Yeast   158 NLVAICALLGTSFYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSEKENSETSKAAQLLTWSMNA 222

  Fly   279 IQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFLSLVAYVYVGDLVTA 343
            .|::::|..::        :.:.:.|.|        .|.|.....|...|::..|.:.....:|
Yeast   223 AQLVRLYCTQR--------LERKKFKEI--------ILNCNTFFIKSCFFVAANAGILRFLTLT- 270

  Fly   344 KKVFILSSYYGL---------LND--SLLHYWPMAITTWAQTL----------VSARRVVEFLLQ 387
              :|:...::|.         :||  :..|...|..:|...||          |:..:::..|
Yeast   271 --MFVQGFWFGSAMIKKGKLNINDVITCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLL-- 331

  Fly   388 VEKPTEESCCRDNPGLELDAEKPKPAQSGRLH--CVQSETKCLSFRKVSASWDKPSIKQPRKPHI 450
                             .|..|..|......|  .:...|..|:|..||.|:  ||  :|.:..:
Yeast   332 -----------------KDGSKRNPLNKTVAHQFPLDYATSDLTFANVSFSY--PS--RPSEAVL 375

  Fly   451 EGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHG-------------RISYAAQ 502
            :.:|.:.:||||..|||..|||||||.:.:|...:...|.:.::|             .|:...|
Yeast   376 KNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQ 440

  Fly   503 QPWVFQGSIRENILFVE---------QYEEKRYRAVVHACQ---LDRDLELLPRGDATVVGERGI 555
            :..:|..::|:|||...         ...|.|: .:..|||   |||.:..||.|..|::|..|:
Yeast   441 RCTLFNDTLRKNILLGSTDSVRNADCSTNENRH-LIKDACQMALLDRFILDLPDGLETLIGTGGV 504

  Fly   556 SLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLK 620
            :|||||:.|:|:|||..|...|...|:.::|:|.....||| |.......||..|::||.:..::
Yeast   505 TLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLM-KAIRHWRKGKTTIILTHELSQIE 568

  Fly   621 SVDQLLLLEGGKLTQQGSYEE-LKDVIT-----HHAALDLEAIEADKQQVKRVLSQVDRTSKQLS 679
            |.|.|.|::.|::.:.|:..| |.|..|     :|       ::.|....|.::.         :
Yeast   569 SDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYH-------LQNDYSDAKTIVD---------T 617

  Fly   680 KGEEKDPATIQDENGNAEQQLQGA----VSYDT------YKAYFRALGAPFLVCLVLSMFVLARG 734
            :.|||...|::..|...|....|:    :.||.      |:|.:
Yeast   618 ETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIY--------------------- 661

  Fly   735 CQAVMDIFISRWATWEEDRGYDSVDDYEATRT--------------KMV--IWYTVLLLLTLALF 783
             |...::...|....||:.|| ::...:.|.:              :|:  |.|..:|:|.|...
Yeast   662 -QKRSNVRTRRVKVEEENIGY-ALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCS 724

  Fly   784 LLR---------TFGFF----------------------FMCLRIS------------------- 798
            |:.         ||.|.                      .:.|.::
Yeast   725 LIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSE 789

  Fly   799 ---LTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVN-------LPQAMMDSLQFLVD 853
               :.|.:::...:.|..|.:|:..      |..:|:|..:.:|       |....:.::...|.
Yeast   790 YWVMDLRNEVMEKLTRKNMDWFSGE------NNKASEISALVLNDLRDLRSLVSEFLSAMTSFVT 848

  Fly   854 VVAVLVIVAIANYWLLIPAAI-MVILLYFCRALYIGASRSLKRIESLTRSPIYSHTN---QTFHG 914
            |..:.:|.|:.:.|.|....| |..|:....|:|.|.   |::.|:..::.:....|   |....
Yeast   849 VSTIGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGI---LQKCETDYKTSVAQLENCLYQIVTN 910

  Fly   915 HSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFS-----FWTDLICVIYILAVTFSF--- 971
            ..||:.:.|....:.|:|     :.......:::.||.:     ..|::| |:.|.|:.:.:
Yeast   911 IKTIKCLQAEFHFQLTYH-----DLKIKMQQIASKRAIATGFGISMTNMI-VMCIQAIIYYYGLK 969

  Fly   972 LVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTS---VERVLEYAQTPSEPPLESPK 1033
            ||:...:.|.::....|..:..::.|...:.|..::.....:   :.|:|:......|....:.:
Yeast   970 LVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEKHNTLEVENNNAR 1034

  Fly  1034 SVNLAAEWPQAGH----------LRFQDLRMRY-SPGDEDILRGLNFESQPMEKIGIVGRTGAGK 1087
            :|.:      |||          :..|:|...| |.....:.:.:||:....:.:||:|.:|.||
Yeast  1035 TVGI------AGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGK 1093

  Fly  1088 SSIIQALFRLALNE-GTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNL--DPFDEKSD 1149
            |:::..|.:|...| |.|:|||.|:....|..||..||::.|.|:||:||:|.||  ...||..:
Yeast  1094 STLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILE 1158

  Fly  1150 ESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVD 1214
            ..::.||..|.:...|.|...||..|:..  :..|.||.|.:|:|||:||::::|::||.|:.:|
Yeast  1159 IEMYDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQRLCIARALLRKSKILILDECTSALD 1221

  Fly  1215 TETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            :.:..:|.|.::........:.|.|....:...:|:.|:..|::||.|....|...: |.|.::|
Yeast  1222 SVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDTLYNNR-GELFQIV 1285

  Fly  1280 -NQN 1282
             ||:
Yeast  1286 SNQS 1289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	295/1352 (22%)
		ABC_membrane	95..360	CDD:294371	49/286 (17%)
		ABCC_MRP_domain1	428..632	CDD:213217	75/228 (33%)
		ABC_membrane	728..994	CDD:294371	59/353 (17%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	73/232 (31%)
STE6	NP_012713.1	MdlB	24..605	CDD:224055	143/627 (23%)
		MdlB	702..1289	CDD:224055	137/610 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100