DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10505 and ABCC11

DIOPT Version :9

Sequence 1:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_001357425.1 Gene:ABCC11 / 85320 HGNCID:14639 Length:1384 Species:Homo sapiens


Alignment Length:1385 Identity:437/1385 - (31%)
Similarity:681/1385 - (49%) Gaps:222/1385 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKKK---NP 76
            |...|.:.|.....|:..:..:..|..||.:.:........|:...:.|...||:|..::   ..
Human    85 PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKA 149

  Fly    77 SLM---------RLIF-----------KVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAY 121
            |::         ||||           .|.|    |:.|:..:||     :....||.::.    
Human   150 SVLLVMLRFQRTRLIFDALLGICFCIASVLG----PILIIPKILE-----YSEEQLGNVVH---- 201

  Fly   122 GQTTVTKESAYLYAMGIVLC------SLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASA 180
                           |:.||      ..|.||.|............|.|.|.:...:.|.::..:
Human   202 ---------------GVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKS 251

  Fly   181 ----SSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGP---------VEACIFGYLMTRQVGWT 232
                :|||     |||..:.|::      |.|..:..||         |...|..|.:   :|:|
Human   252 VIHITSGE-----AISFFTGDVN------YLFEGVCYGPLVLITCASLVICSISSYFI---IGYT 302

  Fly   233 SLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAA 297
            :.|.|...:::.||..:..:.:......:::..|.|:::.:|::..|::||||.|||.|.::|..
Human   303 AFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIED 367

  Fly   298 VRQSEVKAIRGSMSIYAALQC--TNMISKISLFLSLVAYVYVGDLV--------TAKKVFILSSY 352
            :|:.|.|.:.         :|  ...::.|:||:.......|..|:        ||...|.:.:.
Human   368 LRRKERKLLE---------KCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLAS 423

  Fly   353 YGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGR 417
            ..||..|:. :.|:|:.....:..:..|..:|.|| |.|.                       ..
Human   424 LNLLRLSVF-FVPIAVKGLTNSKSAVMRFKKFFLQ-ESPV-----------------------FY 463

  Fly   418 LHCVQSETKCLSFRKVSASWDK--PSI-----------------KQPRK------------PHIE 451
            :..:|..:|.|.|.:.:.||.:  |.|                 .:||.            |.:.
Human   464 VQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELH 528

  Fly   452 GISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENIL 516
            .|:..::.|..:|:.||.|||||:||.|||.|:.|::|.|.|.|.::|..||.|:..|:||||||
Human   529 KINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENIL 593

  Fly   517 FVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFD 581
            ....|::.||..|:|.|.|:|||||||.||.|.:||||::||||||.||:||||||....|||.|
Human   594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLD 658

  Fly   582 DPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVI 646
            |||:||||.|||.:.::|..:.|.||..:||||.:|.|:...|::|||.||:.:.|::.||....
Human   659 DPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKK 723

  Fly   647 THHAALDLEAIEADKQQVKRVLSQVDRTSK--QLSKGEEKDPATIQDE--NGNA----EQQL--- 700
            ..:|.|      ..|...:.....:..|:|  :..|.|.:..||..:|  ||||    |.||   
Human   724 GKYAQL------IQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAGNVPEHQLTQE 782

  Fly   701 ----QGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATW--EEDRGYDS-- 757
                :|::|:..|..|.:|.|...:.|::....||.    ..:.||...|.::  |:..|.:|  
Human   783 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLI----VFLTIFSFWWLSYWLEQGSGTNSSR 843

  Fly   758 ------------VDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLR-ISLTLHDQLYHGI 809
                        .|:.:.:..::|.....|||:.:.:.   :.|.|....| .|..||::|::.:
Human   844 ESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVC---SSGIFTKVTRKASTALHNKLFNKV 905

  Fly   810 IRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLV---DVVAVLVIVAIANYWLLIP 871
            .|..|.||:..|.||:||.|:.|::.:|..||   :.|.||||   .|:|||:||::.:.::|:.
Human   906 FRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLP---IFSEQFLVLSLMVIAVLLIVSVLSPYILLM 967

  Fly   872 AAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQN 936
            .||::::.:....::..|....||:|:.:|||::||...:..|.|:|............|....:
Human   968 GAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTD 1032

  Fly   937 TNSSALFLYVSANR----AFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMC 997
            ..::.|.|::|:.|    .....|:|:.:...|.|.|.   |:.:.||..| :|:...:.|....
Human  1033 AQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFG---ISSTPYSFKV-MAVNIVLQLASSF 1093

  Fly   998 QWGMRQTAEMENNMTSVERVLEYAQ-TPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDE 1061
            |...|...|.|...|:|||:|:|.: ..||.||.. :..:....|||.|.:.|||..|:|.....
Human  1094 QATARIGLETEAQFTAVERILQYMKMCVSEAPLHM-EGTSCPQGWPQHGEIIFQDYHMKYRDNTP 1157

  Fly  1062 DILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISI 1125
            .:|.|:|...:..|.:|||||||:||||:..|||||. ...|.|.|||:||..:||.||||::|:
Human  1158 TVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSV 1222

  Fly  1126 IPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQL 1190
            |||||||.|||:||||||||..:|:.:|.||:...|.|.::.....|...:.:.|.|||:|:|||
Human  1223 IPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQL 1287

  Fly  1191 VCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDA 1255
            :|:|||:||.::::::|||||::|.|||.|||.||:..|..||||.||||:.||::.|.:|||..
Human  1288 LCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGN 1352

  Fly  1256 GQIVEFGAPHKLLQRKDGAL 1275
            |::|||..| ::|::|.|:|
Human  1353 GKVVEFDRP-EVLRKKPGSL 1371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 433/1376 (31%)
ABC_membrane 95..360 CDD:294371 63/293 (22%)
ABCC_MRP_domain1 428..632 CDD:213217 104/234 (44%)
ABC_membrane 728..994 CDD:294371 75/289 (26%)
ABCC_MRP_domain2 1045..1264 CDD:213211 112/219 (51%)
ABCC11NP_001357425.1 PLN03130 85..1373 CDD:215595 437/1385 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..523 2/18 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151564
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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