DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and YOR1

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_011797.3	Gene:	YOR1 / 853198	SGDID:	S000003513	Length:	1477	Species:	Saccharomyces cerevisiae

Alignment Length:	1441	Identity:	408/1441 - (28%)
Similarity:	679/1441 - (47%)	Gaps:	218/1441 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESL----TRNLQPH 66
            |:..:|:..|....||||...|.|:..:.|.|.:..:..:.|::..|....|:|    .:|:..:
Yeast   100 QTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYY 164

  Fly    67 WEKESKK--------------------KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLL 111
            :||..||                    |:..|..|:|......|  :.|::::|......|.|::
Yeast   165 FEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYF--MSIVFAILANCTSGFNPMI 227

  Fly   112 LGGLISYFAYGQTTVTKESAYL----------YAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLA 166
            ...||.:        .:|.|..          ||:|..|...|..|.|:.|.......|.:.:..
Yeast   228 TKRLIEF--------VEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAKSI 284

  Fly   167 CAGLVYRKCLRASASSGEGL-GGQAISVMSIDLS--QFDLTFYFFHDLWKGPVEACIFGYLMTRQ 228
            ......:|...||..:.... .|:..|.::.||:  :|.|:|..|...:...:..||  .|:...
Yeast   285 LTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICI--VLLIVN 347

  Fly   229 VGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGR 293
            :|..:|:||........:..:|.|....|...:....||||.:|.|::..|::||.|.||.::.:
Yeast   348 LGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEK 412

  Fly   294 LIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFL----SLVAYVYV----------GDLVTAK 344
            .|..:|..|:..:| .|.:     ..|.:..:::.|    |||.::.:          |::..:.
Yeast   413 NIQDIRTKEISKVR-KMQL-----SRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPGNIFASL 471

  Fly   345 KVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEK 409
            .:|.:.|..       :.:.|:||.|....::...|:...|   |.|      .|:|...::. |
Yeast   472 SLFQVLSLQ-------MFFLPIAIGTGIDMIIGLGRLQSLL---EAP------EDDPNQMIEM-K 519

  Fly   410 PKPAQSGRL-----HC---------------VQSETK---CLSFRKVSASWDKPSIKQPRKPHIE 451
            |.|....:|     ||               .:.|.|   ..:.:|...:|.|||....:...::
Yeast   520 PSPGFDPKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLD 584

  Fly   452 G---------------------ISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHG 495
            .                     ::|.|..|:|:.|.|.:|:|||:||:|:.|.:....|:|||:|
Yeast   585 NMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNG 649

  Fly   496 RISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGG 560
            .:.... .||:...|:|:||:|...:.:::|..||..|.|..||::||.||.|.:|||||:||||
Yeast   650 DLLMCG-YPWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGG 713

  Fly   561 QKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQL 625
            |||||.|||:||::.|||||||.|:|||::|||.:||:|...:|..|.|||.||.:.|::...::
Yeast   714 QKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRV 778

  Fly   626 LLLEGGKLTQQGSYEELKDVITHHAALDL------EAIEADKQQ---VKRVLSQVDRTSKQLSKG 681
            ::|........|:.:|||  ..:...::|      .:.:.|::|   |...|.|:...|:.....
Yeast   779 IVLGTDGQVDIGTVDELK--ARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELT 841

  Fly   682 EEKDPATIQDENGNA------------EQQLQGAVSYDTYKAYFRA-------LGAPFLVCLVLS 727
            |.|..||...:..|:            |::...::|...|:.|.:|       :..|....||:.
Yeast   842 ELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVG 906

  Fly   728 MFVLARGCQAVMDIFISRWAT-WEEDRGYDSVDDYEATRTKMVIWYTVLL-LLTLALFLLRTFGF 790
                    .....:|.|.|.: |.|::          .:.:...:|..|. ....|.|:.....|
Yeast   907 --------TTFCSLFSSVWLSYWTENK----------FKNRPPSFYMGLYSFFVFAAFIFMNGQF 953

  Fly   791 FFMC---LRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLV 852
            ..:|   :..|..|:.:....|:...|.:.:..|.||:||||:.|..::|..|.:::........
Yeast   954 TILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFA 1018

  Fly   853 DVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHST 917
            ::|.|.|:..:...|..|....::::.......|..:.|.:||:|::.||.:|::.|:...|..|
Yeast  1019 NIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDT 1083

  Fly   918 IRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSF--YS 980
            |::..:..:.........|..:.|.:|.|...|....:.|::.:.:.|.:|  .|.:.::|  .:
Yeast  1084 IKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIIT--LLCVTRAFPISA 1146

  Fly   981 GDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYA-QTPSE-----PPLESPKSVNLAA 1039
            ..||:.:|..:.|..:....:|...:.||:|.|.||::.|| :.|.|     |.:..|:|
Yeast  1147 ASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPES----- 1206

  Fly  1040 EWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRL-ALNEGT 1103
             ||..|.:.|:::...|.||...:|:.||...:..|||||.||||||||:|:.||:|| .|..|.
Yeast  1207 -WPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGK 1270

  Fly  1104 IEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSAL--------DD-- 1158
            |.||.:||.:|||.|||.:::|||||||||.||:|.|||||:|::|:.||.||        ||
Yeast  1271 ILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLP 1335

  Fly  1159 -VKLKK------HVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTE 1216
             |||:|      |....:..|...:::.|||||:|:|||:.|.||::||:::|::||||::||.|
Yeast  1336 EVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYE 1400

  Fly  1217 TDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQ 1281
            ||..||..|..:|.:||:|.|||||.|:::.|.:||::.|::.||..|..|..::|.....:.::
Yeast  1401 TDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSMCSR 1465

  Fly  1282 NDATTVKFLKR 1292
            :......|..|
Yeast  1466 SGIVENDFENR 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	402/1409 (29%)
		ABC_membrane	95..360	CDD:294371	63/291 (22%)
		ABCC_MRP_domain1	428..632	CDD:213217	88/224 (39%)
		ABC_membrane	728..994	CDD:294371	55/272 (20%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	113/236 (48%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	406/1431 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710