DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC1

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001031116.1	Gene:	ABCC1 / 839920	AraportID:	AT1G30400	Length:	1622	Species:	Arabidopsis thaliana

Alignment Length:	1373	Identity:	444/1373 - (32%)
Similarity:	703/1373 - (51%)	Gaps:	175/1373 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFD-SESLTRNLQPHWEKESK 72
            |:|.      ||:.....|.|::.:...|.:..|....:: ||.::| :|:|.|:.|..|:||.:
plant   227 PERH------ANLFDSIFFSWLNPLMTLGSKRPLTEKDVW-HLDTWDKTETLMRSFQKSWDKELE 284

  Fly    73 KKNPSLMRLIFKVYG--------W-------QFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYG 122
            |..|.|:|.:....|        |       |||...:|..||: ::...:|..:|
plant   285 KPKPWLLRALNNSLGGRFWWGGFWKIGNDCSQFVGPLLLNELLK-SMQLNEPAWIG--------- 339

  Fly   123 QTTVTKESAYLYA----MGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSG 183
                     |:||    :|:||..|..:..|.    .|..||.|:|.|....|:||.||.   :.
plant   340 ---------YIYAISIFVGVVLGVLCEAQYFQ----NVMRVGYRLRSALIAAVFRKSLRL---TN 388

  Fly   184 EG----LGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILI 244
            ||    ..|:..::|:.|...........|.:|..|....:...|:.:|:|..|:||..|:|::.
plant   389 EGRKKFQTGKITNLMTTDAESLQQICQSLHTMWSAPFRIIVALVLLYQQLGVASIIGALFLVLMF 453

  Fly   245 PLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGS 309
            |:|......:........:..|.|:.||||::.|:..:|.||||.||...:..||..|:...|.:
plant   454 PIQTVIISKTQKLTKEGLQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKA 518

  Fly   310 MSIYAALQCTNM--ISKISLFLSLVAY----VYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAI 368
            .    .|...||  ::.|.:.:::|::    :..||| |..:.|...|.:.:|...|. ..|..|
plant   519 Q----LLSAFNMFILNSIPVLVTVVSFGVFSLLGGDL-TPARAFTSLSLFSVLRFPLF-MLPNII 577

  Fly   369 TTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKV 433
            |......||..|:.|.|     .|||.....||.:|       |.|           ..:|.|..
plant   578 TQMVNANVSLNRLEEVL-----STEERVLLPNPPIE-------PGQ-----------PAISIRNG 619

  Fly   434 SASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIEL-MQGRVEVHGRI 497
            ..|||    .:..:|.:..|:..|..|..|.:||:.|.||::|:.|:|||:.. ....|.:.|.:
plant   620 YFSWD----SKADRPTLSNINLDIPLGSLVAVVGSTGEGKTSLISAMLGELPARSDATVTLRGSV 680

  Fly   498 SYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQK 562
            :|..|..|:|..::|:||||...:::::|..|:....|..||||||.||.|.:||||:::|||||
plant   681 AYVPQVSWIFNATVRDNILFGAPFDQEKYERVIDVTALQHDLELLPGGDLTEIGERGVNISGGQK 745

  Fly   563 ARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLL 627
            .|:::|||||..:|:.:.||||:|:||.||:.:.:||..|.|....|:|||:.:..|..||::||
plant   746 QRVSMARAVYSNSDVCILDDPLSALDAHVGQQVFEKCIKRELGQTTRVLVTNQLHFLSQVDKILL 810

  Fly   628 LEGGKLTQQGSYEELKDVITHHAALDLEAIE----ADKQQVKRVLSQVDRTS-KQLSKGE----E 683
            :..|.:.::|:||||    .|...|....:|    .:....:...::||:|| |.:..|.    :
plant   811 VHEGTVKEEGTYEEL----CHSGPLFQRLMENAGKVEDYSEENGEAEVDQTSVKPVENGNANNLQ 871

  Fly   684 KDP-ATIQDENGNA-----EQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIF 742
            ||. .|...:.||:     |::..|.||:...:.|..|||..::|.:::..:||.:..:.....:
plant   872 KDGIETKNSKEGNSVLVKREERETGVVSWKVLERYQNALGGAWVVMMLVICYVLTQVFRVSSSTW 936

  Fly   743 ISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLL----TLALFLLRTFGFFFMCLRISLTLHD 803
            :|.|.            |....:|...::|.::..|    .:::.|:.::......|..:..:||
plant   937 LSEWT------------DSGTPKTHGPLFYNIVYALLSFGQVSVTLINSYWLIMSSLYAAKKMHD 989

  Fly   804 QLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVD------VNLPQAMMDSLQFLVDVVAVLVIVA 862
            .:...|:||.|.||..||.||::|||:.|:.::|      ||:   .|.|:..|:..|.::.||:
plant   990 AMLGSILRAPMVFFQTNPLGRIINRFAKDMGDIDRTVAVFVNM---FMGSIAQLLSTVILIGIVS 1051

  Fly   863 IANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQL 927
            ..:.|.::|   ::::.|.....|...||.:||::|.||||:|:...:..:|.|:||:..|..::
plant  1052 TLSLWAIMP---LLVVFYGAYLYYQNTSREIKRMDSTTRSPVYAQFGEALNGLSSIRAYKAYDRM 1113

  Fly   928 EQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYI-----LAVTFSFLVINQSFYSGDVG--- 984
            .:......:.|.....:.::|||......:::..:.:     |||..:....||..|:..:|
plant  1114 AEINGRSMDNNIRFTLVNMAANRWLGIRLEVLGGLMVWLTASLAVMQNGKAANQQAYASTMGLLL 1178

  Fly   985 ---LAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPL-----ESPKSVNLAAEW 1041
               |:||.|:|.|      :|..:..||::.|||||..|.:.|||.||     ..|..      |
plant  1179 SYALSITSSLTAV------LRLASLAENSLNSVERVGNYIEIPSEAPLVIENNRPPPG------W 1231

  Fly  1042 PQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIE 1105
            |.:|.::|:|:.:||.|....:|.|::|...||:|:||||||||||||::.||||:. |.:|.|.
plant  1232 PSSGSIKFEDVVLRYRPELPPVLHGVSFLISPMDKVGIVGRTGAGKSSLLNALFRIVELEKGRIL 1296

  Fly  1106 IDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEG 1170
            ||..|||:.||.|||..:.||||.|||||||:|||||||.|.:|..||.:|:...||..:.....
plant  1297 IDECDIGRFGLMDLRKVLGIIPQAPVLFSGTVRFNLDPFSEHNDADLWESLERAHLKDTIRRNPL 1361

  Fly  1171 GLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVL 1235
            ||...:.:.|.|||:|||||:.||||:||::::||:|||||.||..||:|||:||:.:|..||:|
plant  1362 GLDAEVTEAGENFSVGQRQLLSLARALLRRSKILVLDEATAAVDVRTDVLIQKTIREEFKSCTML 1426

  Fly  1236 TIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFLKRIASESYMR 1300
            .|||||:|::|.|.|||:|:|::.||.:|..||...:.:..|:|........::|:.|..|:...
plant  1427 IIAHRLNTIIDCDKVLVLDSGKVQEFSSPENLLSNGESSFSKMVQSTGTANAEYLRSITLENKRT 1491

  Fly  1301 R--NRRDS 1306
            |  |..||
plant  1492 REANGDDS 1499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	431/1328 (32%)
		ABC_membrane	95..360	CDD:294371	72/278 (26%)
		ABCC_MRP_domain1	428..632	CDD:213217	81/204 (40%)
		ABC_membrane	728..994	CDD:294371	70/286 (24%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	118/219 (54%)
ABCC1	NP_001031116.1	PLN03130	1..1622	CDD:215595	444/1373 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720