DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC5

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_171908.1	Gene:	ABCC5 / 839277	AraportID:	AT1G04120	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1344	Identity:	419/1344 - (31%)
Similarity:	683/1344 - (50%)	Gaps:	146/1344 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEK---ESKKKNP 76
            |:..|.::|.....|:..:...|.:..|:...:....|...::|..:.|:.:|::   |:..|.|
plant   229 PYSTAGLVSLITLSWLDPLLSAGSKRPLELKDIPLLAPRDRAKSSYKVLKSNWKRCKSENPSKPP 293

  Fly    77 SLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGIVLC 141
            ||.|.|.|.: |:......:::.|...:....|.|:...:.|.  |...:.....|:.| ||...
plant   294 SLARAIMKSF-WKEAACNAVFAGLNTLVSYVGPYLISYFVDYL--GGKEIFPHEGYVLA-GIFFT 354

  Fly   142 S-LVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEG-LGGQAISVMSIDLSQFDLT 204
            | |:.::....:...|..:|..||.|...:||||.|:.|:.:.:. ..|:.::.|::|:.:....
plant   355 SKLIETVTTRQWYMGVDILGMHVRSALTAMVYRKGLKLSSIAKQNHTSGEIVNYMAVDVQRIGDY 419

  Fly   205 FYFFHDLWKGPVEACIFGYLMTRQVG----WTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHR 265
            .::.||:|..|::..:...::.:.||    .|.:..|..|::.|||    ||....:..:....:
plant   420 SWYLHDIWMLPMQIVLALAILYKSVGIAAVATLVATIISILVTIPL----AKVQEDYQDKLMTAK 480

  Fly   266 DARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFLS 330
            |.|::..:|.:..::|:|:.|||..:...:..:|:.|...:|  .::|:....|.:.....:|::
plant   481 DERMRKTSECLRNMRVLKLQAWEDRYRVRLEEMREEEYGWLR--KALYSQAFVTFIFWSSPIFVA 543

  Fly   331 LVAY---VYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPT 392
            .|.:   :::|..:||..|....:.:.:|.:.|.:: |..::..|||.||..|:..||.:.|
plant   544 AVTFATSIFLGTQLTAGGVLSALATFRILQEPLRNF-PDLVSMMAQTKVSLDRISGFLQEEE--- 604

  Fly   393 EESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHI 457
                      |:.||....|.   .|..:..|.|...|     .||..|    .:|.:.||...:
plant   605 ----------LQEDATVVIPR---GLSNIAIEIKDGVF-----CWDPFS----SRPTLSGIQMKV 647

  Fly   458 NAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYE 522
            ..|..|.:.|.||||||:.:..|||||..:.|.|.:.|...|.:|..|:..|:|.|||||....|
plant   648 EKGMRVAVCGTVGSGKSSFISCILGEIPKISGEVRICGTTGYVSQSAWIQSGNIEENILFGSPME 712

  Fly   523 EKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAV 587
            :.:|:.|:.||.|.:|:||...||.|::|||||:||||||.|:.||||:|:.|||||.|||.:|:
plant   713 KTKYKNVIQACSLKKDIELFSHGDQTIIGERGINLSGGQKQRVQLARALYQDADIYLLDDPFSAL 777

  Fly   588 DAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKD-------- 644
            ||..|..|........|..|..:.|||.|:.|.:.|.:|:|:.|::.|.|.|::|..
plant   778 DAHTGSDLFRDYILSALAEKTVVFVTHQVEFLPAADLILVLKEGRIIQSGKYDDLLQAGTDFKAL 842

  Fly   645 VITHHAALDLEAI------EADKQQVKRVL-----------SQVDRTSKQLSK-GEEKDPATIQD 691
            |..||.|::...|      ::|:..::..|           :.::..:|::.: |...|...|::
plant   843 VSAHHEAIEAMDIPSPSSEDSDENPIRDSLVLHNPKSDVFENDIETLAKEVQEGGSASDLKAIKE 907

  Fly   692 ENGNA-----------EQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISR 745
            :...|           |::::|.||...|.:|   :||.:...|: .:.:||:.....:.|..:.
plant   908 KKKKAKRSRKKQLVQEEERVKGKVSMKVYLSY---MGAAYKGALI-PLIILAQAAFQFLQIASNW 968

  Fly   746 WATWEEDRGYDSVDDYEATRTKMVIWYTVL-----LLLTLALFLLRTFGFFFMCLRISLTLHDQL 805
            |..|...:  ...|:.:...|.::|.||.|     :.:.:...|:.|||     |..:..|...:
plant   969 WMAWANPQ--TEGDESKVDPTLLLIVYTALAFGSSVFIFVRAALVATFG-----LAAAQKLFLNM 1026

  Fly   806 YHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAM----MDSLQFLVDVVAVLVIVAIANY 866
            ...:.||.|.||::.|:||:|||.|.|...||:::|..:    ..::| |..:|||:..|....:
plant  1027 LRSVFRAPMSFFDSTPAGRILNRVSIDQSVVDLDIPFRLGGFASTTIQ-LCGIVAVMTNVTWQVF 1090

  Fly   867 WLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTF 931
            .|::|.|   :..::.:..|:.:||.|.||.|:.:|||.....::..|.:|||.          |
plant  1091 LLVVPVA---VACFWMQKYYMASSRELVRIVSIQKSPIIHLFGESIAGAATIRG----------F 1142

  Fly   932 HGHQNTNSSALFLYVSANRAFSFWT----DLICVIYILAVTFSF---LVINQSFYSGDV-----G 984
            ...:......|:|.....|.| |.:    :.:|:...|..|..|   :|:..||..|.:     |
plant  1143 GQEKRFIKRNLYLLDCFVRPF-FCSIAAIEWLCLRMELLSTLVFAFCMVLLVSFPHGTIDPSMAG 1206

  Fly   985 LAITQSMTL-VIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPP-----LESPKSVNLAAEWPQ 1043
            ||:|..:.| ..:.:| :....::||.:.|:||:.:|:|...|.|     ...|.|      ||.
plant  1207 LAVTYGLNLNGRLSRW-ILSFCKLENKIISIERIYQYSQIVGEAPAIIEDFRPPSS------WPA 1264

  Fly  1044 AGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRL-ALNEGTIEID 1107
            .|.:...|:::||:.....:|.|::......:|||||||||:|||::||||||| ....|.|.||
plant  1265 TGTIELVDVKVRYAENLPTVLHGVSCVFPGGKKIGIVGRTGSGKSTLIQALFRLIEPTAGKITID 1329

  Fly  1108 GLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGL 1172
            .:||.::||||||||:.||||||.||.||:|.||||.:|.||:.:|.|||..:|...|...:..|
plant  1330 NIDISQIGLHDLRSRLGIIPQDPTLFEGTIRANLDPLEEHSDDKIWEALDKSQLGDVVRGKDLKL 1394

  Fly  1173 SCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTI 1237
            ...:.:.|.|:|:||||||.|.||:|:|.::||:|||||:|||.||.|||:.|:|:|.:|||.||
plant  1395 DSPVLENGDNWSVGQRQLVSLGRALLKQAKILVLDEATASVDTATDNLIQKIIRTEFEDCTVCTI 1459

  Fly  1238 AHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQ 1281
            |||:.||:|:|.|||:..|::.||..|.:||:.|....||||.:
plant  1460 AHRIPTVIDSDLVLVLSDGRVAEFDTPARLLEDKSSMFLKLVTE 1503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	412/1329 (31%)
		ABC_membrane	95..360	CDD:294371	59/273 (22%)
		ABCC_MRP_domain1	428..632	CDD:213217	86/203 (42%)
		ABC_membrane	728..994	CDD:294371	75/287 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	114/219 (52%)
ABCC5	NP_171908.1	MRP_assoc_pro	229..1493	CDD:188098	414/1332 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720