DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC9

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_191575.2	Gene:	ABCC9 / 825186	AraportID:	AT3G60160	Length:	1506	Species:	Arabidopsis thaliana

Alignment Length:	1330	Identity:	405/1330 - (30%)
Similarity:	688/1330 - (51%)	Gaps:	134/1330 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESK----K 73
            |:|:..|.:..:..|.|::.:|..|.:..|:.    :.:|..|.:...|.....::::.|    |
plant   234 SSPYGNATLFQRITFSWINPLFSLGYKRPLEK----DDVPDIDVKDSARFCSHAFDQKLKTTKEK 294

  Fly    74 KNP-------SLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESA 131
            :.|       |::|     |.|:...:..:::::..:.....|.|:...:.:.:..|:. :....
plant   295 EGPGNAFFYNSVLR-----YVWRKAAINAVFAVVNASTAYIGPYLINDFVEFLSEKQSQ-SLNHG 353

  Fly   132 YLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEG-LGGQAISVMS 195
            ||.|:|.:...:|.::....::|....:|.|:|.|....:|:|.|..|:.|.:. ..|:.|:.||
plant   354 YLLALGFLTAKIVETVTQRQWIFGARQLGLRLRAALISHIYQKGLVLSSQSRQSHTSGEIINYMS 418

  Fly   196 IDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTR 260
            :|:.:.....::.:::|..|::.....|::.:.:|..:|..:...::::.......:...::.:.
plant   419 VDVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQSD 483

  Fly   261 SAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMI--- 322
            ....:|.|:|..:||:..::::|:.||:..|...:..:|:.|...:..|:.:.|   .|..|
plant   484 IMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQA---FTTFILWG 545

  Fly   323 --SKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFL 385
              |.||: ::.|..:.:|..:||..|....:.:.:|...:... |..::...|:.|||.|:..:|
plant   546 APSLISV-VTFVTCMLMGVKLTAGAVLSALATFQMLQSPIFGL-PDLLSALVQSKVSADRIASYL 608

  Fly   386 LQVE--KPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKP 448
            .|.|  |...|.|.:|:..|.::.|..                       :.||:..|    .:|
plant   609 QQSETQKDAVEYCSKDHTELSVEIENG-----------------------AFSWEPES----SRP 646

  Fly   449 HIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRE 513
            .::.|...:.:|..|.:.|.||||||:||.:|||||:.::|.|.|.|:.:|..|.||:..|:||:
plant   647 TLDDIELKVKSGMKVAVCGAVGSGKSSLLSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIRD 711

  Fly   514 NILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIY 578
            ||||...||.::|...|.||.|.:|.||...||.|.:|||||::|||||.||.:|||||:.||||
plant   712 NILFGSMYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIY 776

  Fly   579 LFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELK 643
            |.|||.:||||..|:.|.:.|...:|..|..:.|||.|:.|.:.|.:|:::.|::.|.|.:|||.
plant   777 LLDDPFSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEELL 841

  Fly   644 D--------VITHHAALDLEAIEADKQQVKRVLSQVDRTSKQLSKGEEKDPATIQD--------- 691
            .        |..|:.|||            .:|| ::::|:...:|.:.|.|:|.:
plant   842 KQNIGFEVLVGAHNEALD------------SILS-IEKSSRNFKEGSKDDTASIAESLQTHCDSE 893

  Fly   692 -----ENGNAEQQL-------QGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFIS 744
                 ||...|.:|       :|.:..:.|.||...:....||..:    :||:.|..::.|..:
plant   894 HNISTENKKKEAKLVQDEETEKGVIGKEVYLAYLTTVKGGLLVPFI----ILAQSCFQMLQIASN 954

  Fly   745 RWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGI 809
            .|..|......:|:......|..:|  |.:|...:....|.||.......|..:.|...::...|
plant   955 YWMAWTAPPTAESIPKLGMGRILLV--YALLAAGSSLCVLARTILVAIGGLSTAETFFSRMLCSI 1017

  Fly   810 IRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVA-IANYW----LL 869
            .||.|.||::.|:||:|||.|:|...:|:.:...:......::.:|..:.::: :|  |    :.
plant  1018 FRAPMSFFDSTPTGRILNRASTDQSVLDLEMAVKLGWCAFSIIQIVGTIFVMSQVA--WQVCVIF 1080

  Fly   870 IPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGH 934
            ||.|:..:   |.:..|...:|.|.|:..:.|:||..|..::..|.:|||:.|...:...:....
plant  1081 IPVAVACV---FYQRYYTPTARELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVL 1142

  Fly   935 QNTNSSALFLYVSANRAFSFWTDLI-----CVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLV 994
            .:::|...|...||....||..:|:     ....:|.||....|||.|.    .||.:|..::|.
plant  1143 IDSHSRPWFHVASAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSI----AGLGVTYGLSLN 1203

  Fly   995 IMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPL--ESPKSVNLAAEWPQAGHLRFQDLRMRYS 1057
            ::....:......||.|.||||:|:|::.|||.||  :..:.::   .||..|.:.|:||::||:
plant  1204 VLQATVIWNICNAENKMISVERILQYSKIPSEAPLVIDGHRPLD---NWPNVGSIVFRDLQVRYA 1265

  Fly  1058 PGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRS 1121
            .....:|:.:..|....:|||:|||||:|||::||||||:. .::|||.||.:||.|:|||||||
plant  1266 EHFPAVLKNITCEFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRS 1330

  Fly  1122 RISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMG 1186
            |:.||||||.||.||:|.||||..:.:|..:|.|:|..:|...:.:.:..|...:.:.|.|:|:|
plant  1331 RLGIIPQDPALFDGTIRLNLDPLAQYTDHEIWEAIDKCQLGDVIRAKDERLDATVVENGENWSVG 1395

  Fly  1187 QRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVL 1251
            |||||||.|.:|:::.:||:|||||:||:.||.:||:.|..:|.:.||:|||||:|||:::|.||
plant  1396 QRQLVCLGRVLLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVL 1460

  Fly  1252 VMDAGQIVEFGAPHKLLQRKDGALLKLVNQ 1281
            |:..|:|.||.:|.|||||:|....||:.:
plant  1461 VLSDGRIAEFDSPAKLLQREDSFFSKLIKE 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	398/1315 (30%)
		ABC_membrane	95..360	CDD:294371	52/270 (19%)
		ABCC_MRP_domain1	428..632	CDD:213217	90/203 (44%)
		ABC_membrane	728..994	CDD:294371	68/275 (25%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	108/219 (49%)
ABCC9	NP_191575.2	PLN03232	68..1488	CDD:215640	404/1326 (30%)
		ABC_membrane	319..586	CDD:294371	52/271 (19%)
		ABCC_MRP_domain1	630..830	CDD:213217	91/226 (40%)
		ABC_membrane	973..1209	CDD:294371	62/246 (25%)
		ABCC_MRP_domain2	1253..1473	CDD:213211	108/219 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720