DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC8

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001326629.1	Gene:	ABCC8 / 821679	AraportID:	AT3G21250	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1347	Identity:	406/1347 - (30%)
Similarity:	668/1347 - (49%)	Gaps:	169/1347 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHW----- 67
            :|::||.....|...|...|.||:.:...|.::.|....:...:|..:::...:.....|
plant   201 NPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDTLLG 265

  Fly    68 EKESKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAY 132
            ::.|.|:...:.|.:.|||..:.:.:.:...|...|:.|. ||:|...:.|.......:  .:.:
plant   266 DESSTKERNLVFRAVVKVYFKENIFIAVFAFLRTFAVVSL-PLMLYVFVDYANSDHRDL--RNGF 327

  Fly   133 LYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASA------SSGEGLGGQAI 191
            .....:|:..||.||....:.|.....|.|:|.|.....|:|.|:.|:      ||||     .:
plant   328 FNLACLVMLKLVESLTMRHWYFASRRSGMRIRSALMVAAYKKQLKLSSLGRKRHSSGE-----IV 387

  Fly   192 SVMSIDLSQFDLTFYFFHDLWKGPVE-----ACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAA 251
            :.:::|..:.....::||..|...::     |.:||.     ||..:..|:..:::...|....|
plant   388 NYIAVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGV-----VGAGAFPGLILLLLCGLLNLPFA 447

  Fly   252 KASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAAL 316
            |...:..|:....:|.|::..:||:.:::|||:.:||..|.:.|.:.|..|       .:..|..
plant   448 KMLQNCQTQFMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDE-------FTWLAKA 505

  Fly   317 QCTNMISKISLFLS---LVAYVYVGDL------VTAKKVFILSSYYGLLNDSLLHYWPMAITTWA 372
            |.|........::|   :.:.|::|..      :.|..:|.:.:...::::. :...|.||:...
plant   506 QLTKAFGSFLYWMSPTIVSSVVFLGCALLKSAPLNASTIFTVLATLRVMSEP-VKIIPDAISAII 569

  Fly   373 QTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASW 437
            |..||.:|:..|||..|...:|.   :..||:         .||         ..:..:..:..|
plant   570 QGNVSFQRLNNFLLDDELKMDEI---ERSGLD---------ASG---------TAVDIQVGNFGW 613

  Fly   438 DKPSIKQP--RKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYA 500
            : |..|.|  |..|:|     |..||.|.:.|.||:|||:||||:||||..:.|.|:|.|.|:|.
plant   614 E-PETKIPTLRNIHLE-----IKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVSGTVKVFGSIAYV 672

  Fly   501 AQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARI 565
            :|..|:..|:||:|||:.:..|.:||.|.:.||.||:|:.....||.|.:|:|||:||||||.||
plant   673 SQTSWIQSGTIRDNILYGKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQRGINLSGGQKQRI 737

  Fly   566 ALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEG 630
            .||||||..||:||.|||.:||||....:|..||....|..|..|||||.|:.|..|||:|::|.
plant   738 QLARAVYADADVYLLDDPFSAVDAHTAGVLFHKCVEDSLKEKTVILVTHQVEFLSEVDQILVMEE 802

  Fly   631 GKLTQQGSYEEL--------------KDVIT------HHAALDLEAIEADKQ-----QVKRVLSQ 670
            |.:||.|.||||              .|.:|      :.:..||.....|::     .|:::..:
plant   803 GTITQSGKYEELLMMGTAFQQLVNAHNDAVTVLPLASNESLGDLRKEGKDREIRNMTVVEKIEEE 867

  Fly   671 VDRT---SKQLSKGEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLA 732
            :::|   ..||::.|||       |:|           |...|.:...:|.....||:.|. ||.
plant   868 IEKTDIPGVQLTQEEEK-------ESG-----------YVGMKPFLDYIGVSRGWCLLWSS-VLG 913

  Fly   733 RGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRI 797
            :....|.....:.|..:       ::...:.|.|.::..|:::..|:......|......:.|:.
plant   914 QVGFVVFQAASTYWLAF-------AIGIPKITNTMLIGVYSIISTLSAGFVYARAITTAHLGLKA 971

  Fly   798 SLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVA 862
            |........:.:.:|.|.||::.|.||:|.|.|||:..:|.::|.|.:..:...|::.|.|:|:.
plant   972 SKAFFSGFTNAVFKAPMLFFDSTPVGRILTRASSDLNVLDYDVPFAFIFVVAPAVELTAALLIMT 1036

  Fly   863 IANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQL 927
            ...:.::|.|.:.:......:..|:.::|.|.||...|::|:.::..:|..|..|||   |....
plant  1037 YVTWQVIIIALLALAATKVVQDYYLASARELIRINGTTKAPVMNYAAETSLGVVTIR---AFGTA 1098

  Fly   928 EQTFHGHQNTNSSALFLYVSANRAFSFW-----------TDLICVIYILAVTFSFLVINQSFYSG 981
            |:.|..:.|...:...|:..:|.|.. |           |...|.:.::.:...::.      .|
plant  1099 ERFFKNYLNLVDADAVLFFLSNAAME-WVILRIETLQNVTLFTCALLLILIPKGYIA------PG 1156

  Fly   982 DVGLAITQSMTL----VIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPL----ESPKSVNLA 1038
            .|||:::.::||    |.:.:|    ...:.|::.||||:.:|...|.|||.    :.|.|
plant  1157 LVGLSLSYALTLTQTQVFLTRW----YCTLSNSIISVERIKQYMNIPEEPPAIIDDKRPPS---- 1213

  Fly  1039 AEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEG 1102
             .||..|.:..|:|::||.|....:|:|::...:...::|:|||||:|||::|.|||||. ...|
plant  1214 -SWPSNGTIHLQELKIRYRPNAPLVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASG 1277

  Fly  1103 TIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVAS 1167
            .|.|||:||.|:||.|||.::|||||:|.||.|.:|.||||....||:.:|.||:..:||..:::
plant  1278 CILIDGIDISKIGLKDLRMKLSIIPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISN 1342

  Fly  1168 LEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAEC 1232
            |...|...:.|.|.|:|:|||||.||.|.:|::|::||:|||||::|:.||.:||..|:.:||:|
plant  1343 LPNKLDSSVSDEGENWSVGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADC 1407

  Fly  1233 TVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            ||:|:|||:.||:|:|.|:|:..|.:||:..|.||:: .|....|||
plant  1408 TVITVAHRVPTVIDSDMVMVLSFGDLVEYNEPSKLME-TDSYFSKLV 1453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	400/1330 (30%)
		ABC_membrane	95..360	CDD:294371	60/284 (21%)
		ABCC_MRP_domain1	428..632	CDD:213217	97/205 (47%)
		ABC_membrane	728..994	CDD:294371	60/280 (21%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	104/219 (47%)
ABCC8	NP_001326629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720