DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC7

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_187917.3	Gene:	ABCC7 / 820498	AraportID:	AT3G13100	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	1333	Identity:	430/1333 - (32%)
Similarity:	672/1333 - (50%)	Gaps:	115/1333 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNL------QPHWEK-ESK 72
            ||..|..:|...|.||..:...|..:.:|:    |.:|..|:......|      :..|:. |.:
plant   231 PFSNAGFLSHVSFSWMSPLIVLGNEKIIDS----EDVPQVDNSDRAEKLFWIFRSKLEWDDGERR 291

  Fly    73 KKNPSLMR-LIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAM 136
            .....|:: |.|.|  |:.:.:..|::.:........|.|:...:.|. .||...:.:...|...
plant   292 ITTYKLIKALFFSV--WRDILLSTLFAFVYTVSCYVAPYLMDTFVQYL-NGQRQYSNQGVVLVTT 353

  Fly   137 GIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEG-LGGQAISVMSIDLSQ 200
            ..| ..||.......:.|.:...|..:|.....::|.|.|.....|.:| ..|:.|::|::|..:
plant   354 FFV-AKLVECQARRNWYFRLQKAGIGMRSVLVSMIYEKGLTLPCYSKQGHTSGEIINLMTVDAER 417

  Fly   201 FDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIA--FIVIL--IPLQAWAAKASASFGTRS 261
            .....::.||.|...::..:...::.|.:|..|:...|  |:|:|  |||    ||....|....
plant   418 ISAFSWYMHDPWILVLQISLALLILYRSLGLGSIAAFAATFLVMLGNIPL----AKLEEKFQGNL 478

  Fly   262 AKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISKIS 326
            .:.:|.|:|..:|.:..::::|:..||..|...|..:|..|...::  ..:|.:...::::....
plant   479 MESKDNRMKKTSEALLNMRILKLQGWEMKFLHKILDLRGIEAGWLK--KFVYNSAAISSVLWAAP 541

  Fly   327 LFLSLVAY---------VYVGDLVTAKKVF--ILSSYYGLLNDSLLHYWPMAITTWAQTLVSARR 380
            .|:|..|:         :..|.::.|...|  :.:..|.|         |..|:...||.||..|
plant   542 SFVSATAFGACMLLKIPLESGKIIAALATFRILQTPIYKL---------PDTISMIVQTKVSLDR 597

  Fly   381 VVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQP 445
            :..||           |.|:  |:.|..:..|:.|.::....|..        :.|||..|
plant   598 IATFL-----------CLDD--LQQDGMERLPSGSSKMDVEVSNG--------AFSWDDSS---- 637

  Fly   446 RKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGS 510
            ..|.::.|.|.|..|..:.|.|.||||||:||.:||||:..:.|.::|.||.:|.||.||:..|.
plant   638 PIPTLKDIRFKIPHGMNIAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWIQSGK 702

  Fly   511 IRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQA 575
            :.|||||.:..:.:.|:.|:.||.|::|||:.|..|.||:|||||:||||||.||.:|||:|:.|
plant   703 VEENILFGKPMQREWYQRVLEACSLNKDLEVFPFRDQTVIGERGINLSGGQKQRIQIARALYQDA 767

  Fly   576 DIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYE 640
            ||||||||.:||||..|..|..:....||..|..|.|||.::.|...|.:|:::.|::||.|.|.
plant   768 DIYLFDDPFSAVDAHTGSHLFKEVLLGLLRNKTVIYVTHQLEFLPEADLILVMKDGRITQAGKYN 832

  Fly   641 ELKDVITHHAAL---DLEAIEADKQQVKRVLSQVDRTSKQ--LSKGEEKDPATIQDENG---NAE 697
            |:.:..|....|   ..:|:.|.....|...|....|||:  :|..|||....:....|   ..|
plant   833 EILESGTDFMELVGAHTDALAAVDSYEKGSASAQSTTSKESKVSNDEEKQEEDLPSPKGQLVQEE 897

  Fly   698 QQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYE 762
            ::.:|.|.:..|:.|.:......||.::|.:.:|.:    |::|..:.|..|......| |....
plant   898 EREKGKVGFTVYQKYMKLAYGGALVPIILVVQILFQ----VLNIGSNYWMAWVTPVSKD-VKPLV 957

  Fly   763 ATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLN 827
            :..| :::.|..|...:....|:|.........:|:..|.:|::..|.||.|.||:|.|.||:||
plant   958 SGST-LILVYVFLATASSFCILVRAMLSAMTGFKIATELFNQMHFRIFRASMSFFDATPIGRILN 1021

  Fly   828 RFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRS 892
            |.|:|...||:.||....:.....|:::.::.::....:.:||....::....:.|..||.|:|.
plant  1022 RASTDQSAVDLRLPSQFSNLAIAAVNILGIIGVMGQVAWQVLIVFIPVIAACTWYRQYYISAARE 1086

  Fly   893 LKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTD 957
            |.|:..::|||:..|.::|..|.:||||.|..|:.........:..|...|..:||.....|..|
plant  1087 LARLSGISRSPLVQHFSETLSGITTIRSFDQEPRFRTDIMRLNDCYSRLRFHAISAMEWLCFRLD 1151

  Fly   958 LICVI-----YILAVTFSFLVINQSFYSGDVGLAITQSM-------TLVIMCQWGMRQTAEMENN 1010
            |:..:     .::.|:....|||.||    .|||:|.::       ||:    |.:   .::||.
plant  1152 LLSTVAFALSLVILVSVPEGVINPSF----AGLAVTYALNLNSLQATLI----WTL---CDLENK 1205

  Fly  1011 MTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPME 1075
            |.||||:|:|...||||.|.. :|......||..|.:...:|::||.|....:||||....:...
plant  1206 MISVERMLQYIDIPSEPSLVI-ESTRPEKSWPCRGEITICNLQVRYGPHLPMVLRGLTCTFRGGL 1269

  Fly  1076 KIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRF 1139
            |.|||||||.|||::||.|||:. ...|.|.|||::|..:||||||||:|||||:|.:|.||:|.
plant  1270 KTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGINILTIGLHDLRSRLSIIPQEPTMFEGTVRS 1334

  Fly  1140 NLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVL 1204
            ||||.:|.:|:.:|.|||..:|...:...|..|...:.:.|.|:|:||||||||.|.:|::::||
plant  1335 NLDPLEEYADDQIWEALDKCQLGDEIRKKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRSKVL 1399

  Fly  1205 VMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            ::|||||:|||.||.|||||::..|:.|||:|||||:.:|:|:|.||::|.|.|.|..:|.:||:
plant  1400 ILDEATASVDTATDTLIQETLRQHFSGCTVITIAHRISSVIDSDMVLLLDQGLIEEHDSPARLLE 1464

  Fly  1270 RKDGALLKLVNQNDATTVKFLKRIASESYMRRN 1302
            .|..:..|||.:..|::....||    |.|:.|
plant  1465 DKSSSFSKLVAEYTASSDSRFKR----SSMKTN 1493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	418/1297 (32%)
		ABC_membrane	95..360	CDD:294371	58/280 (21%)
		ABCC_MRP_domain1	428..632	CDD:213217	92/203 (45%)
		ABC_membrane	728..994	CDD:294371	74/277 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	110/219 (50%)
ABCC7	NP_187917.3	PLN03232	34..1474	CDD:215640	422/1308 (32%)
		ABC_membrane	309..578	CDD:294371	56/276 (20%)
		ABCC_MRP_domain1	624..824	CDD:213217	93/211 (44%)
		ABC_membrane	925..1199	CDD:294371	77/287 (27%)
		ABCC_MRP_domain2	1239..1459	CDD:213211	110/219 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720