DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC3

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_187915.1	Gene:	ABCC3 / 820496	AraportID:	AT3G13080	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1339	Identity:	422/1339 - (31%)
Similarity:	689/1339 - (51%)	Gaps:	149/1339 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSF-DSESLTRNLQPHWEK--ES-- 71
            |:.|:.:|.|:|...|.||..:...|.::.||    .|.:|.. |::|:. .|.|.:..  ||
plant   242 EATPYSRAGILSLLTFSWMSPLIDIGNKKTLD----LEDVPQLHDTDSVV-GLAPKFRSMLESPD 301

  Fly    72 --KKKNPSLMRLIFKVY---GWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESA 131
              ::...:..:||..:|   .|:.: |...::.:........|.|:...:.|. .|:.....| .
plant   302 GGERSGVTTFKLIKALYFTAQWEIL-VTAFFAFIYTVASYVGPALIDTFVQYL-NGRRQYNHE-G 363

  Fly   132 YLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEG-LGGQAISVMS 195
            |:..:......:|..|....:.|.:..||.|:|.|...::|.|.|..|..|.:| ..|:.|:.|:
plant   364 YVLVITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQGRTSGEIINFMT 428

  Fly   196 IDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTR 260
            :|..:.....::.||.|...::..:..:::.|.:|..|:..:...:|::.:.....:....|..:
plant   429 VDAERIGNFSWYMHDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPFGRMQERFQEK 493

  Fly   261 SAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSE----VKAIRGSMSIYAALQCTNM 321
            ..:.:|:|:|..:||:..::::|:..||..|...|..:|:||    .|.:..|..|.........
plant   494 LMEAKDSRMKSTSEILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYVYNSAVISFVFWGAPT 558

  Fly   322 ISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLL 386
            :..:|.|   .|.:.:|..:.:.|:....:.:.:|.:.:.:. |..|:...||.||..|:..:|
plant   559 LVSVSTF---GACILLGIPLESGKILSALATFRILQEPIYNL-PDTISMIVQTKVSLDRLASYL- 618

  Fly   387 QVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIE 451
                      |.||...::....||.:....:..:.|          :.|||..|    ..|.::
plant   619 ----------CLDNLQPDIVERLPKGSSDVAVEVINS----------TLSWDVSS----SNPTLK 659

  Fly   452 GISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENIL 516
            .|:|.:..|..|.:.|.||||||:||.::|||:..:.|.::|.|..:|.||.||:..|.|.:|||
plant   660 DINFKVFPGMKVAVCGTVGSGKSSLLSSLLGEVPKVSGSLKVCGTKAYVAQSPWIQSGKIEDNIL 724

  Fly   517 FVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFD 581
            |.:..|.:||..|:.||.|.:|||:|..||.||:|||||:||||||.||.:|||:|:.|||||||
plant   725 FGKPMERERYDKVLEACSLSKDLEILSFGDQTVIGERGINLSGGQKQRIQIARALYQDADIYLFD 789

  Fly   582 DPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKD-- 644
            ||.:||||..|..|..:....||..|..|.|||.|:.|.:.|.:|:::.|:::|.|.|.::.:
plant   790 DPFSAVDAHTGSHLFKEVLLGLLCSKSVIYVTHQVEFLPAADLILVMKDGRISQAGKYNDILNSG 854

  Fly   645 ------VITHHAALD-LEAIEADKQQVKRVLSQ----------VD-RTSKQLSKGEEKDPATIQD 691
                  :..|..||. :::::|:....|..|.|          || :...|..|.::.:....|.
plant   855 TDFMELIGAHQEALAVVDSVDANSVSEKSALGQENVIVKDAIAVDEKLESQDLKNDKLESVEPQR 919

  Fly   692 ENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYD 756
            :....|::.:|:|:.|.|..|........||..:|...||.:    ::.|..:.|..|.....
plant   920 QIIQEEEREKGSVALDVYWKYITLAYGGALVPFILLGQVLFQ----LLQIGSNYWMAWATPVS-- 978

  Fly   757 SVDDYEA---TRTKMVIWYTVL----LLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWM 814
              :|.:|   ..|.|:::..:.    |.:.|...||.|.|:     :.:..|..:::|.|.|:.|
plant   979 --EDVQAPVKLSTLMIVYVALAFGSSLCILLRATLLVTAGY-----KTATELFHKMHHCIFRSPM 1036

  Fly   815 YFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQF---LVDVVAVLVIVAIANY--WLLIPAAI 874
            .||::.||||:::|.|:|...||:.||      .||   .:.|:.::.|:.:.:.  ||:....|
plant  1037 SFFDSTPSGRIMSRASTDQSAVDLELP------YQFGSVAITVIQLIGIIGVMSQVSWLVFLVFI 1095

  Fly   875 MVIL--LYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNT 937
            .|:.  :::.| .||.|:|.|.|:..:.::|:..|.::|..|.:||||.
plant  1096 PVVAASIWYQR-YYIAAARELSRLVGVCKAPLIQHFSETISGATTIRSF---------------- 1143

  Fly   938 NSSALFLYVSANRAFS-------FWT----DLIC--VIYILAVTFSF-LVINQSFYSGDV----- 983
              |..|.:.|.|...|       |:|    :.:|  :..:.::||.| ||...|..:|.:
plant  1144 --SQEFRFRSDNMRLSDGYSRPKFYTAGAMEWLCFRLDMLSSLTFVFSLVFLVSIPTGVIDPSLA 1206

  Fly   984 GLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPL--ESPKSVNLAAEWPQAGH 1046
            |||:|..::|..:..|.:.....:||.:.||||:|:||..||||||  ||.:.   ...||..|.
plant  1207 GLAVTYGLSLNTLQAWLIWTLCNLENKIISVERILQYASVPSEPPLVIESNRP---EQSWPSRGE 1268

  Fly  1047 LRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLD 1110
            :..:||::||:|....:|||:....:...:.|||||||:|||::||.|||:. .:.|.|.|||::
plant  1269 VEIRDLQVRYAPHMPLVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAGEIRIDGVN 1333

  Fly  1111 IGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCR 1175
            |..:||||||.|:|||||||.:|.||:|.||||.:|.:|:.:|.|||..:|...|...|..|...
plant  1334 ILTIGLHDLRLRLSIIPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVRKKEQKLDSS 1398

  Fly  1176 MQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHR 1240
            :.:.|.|:||||||||||.|.:|:::::||:|||||:|||.||.|||:|::..|::|||:|||||
plant  1399 VSENGDNWSMGQRQLVCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSDCTVITIAHR 1463

  Fly  1241 LHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            :.:|:|:|.||::..|.|.|:..|.:||:.|..:..|||
plant  1464 ISSVIDSDMVLLLSNGIIEEYDTPVRLLEDKSSSFSKLV 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	416/1326 (31%)
		ABC_membrane	95..360	CDD:294371	54/269 (20%)
		ABCC_MRP_domain1	428..632	CDD:213217	93/203 (46%)
		ABC_membrane	728..994	CDD:294371	75/298 (25%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	109/219 (50%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	419/1334 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720