DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC2

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1375	Identity:	436/1375 - (31%)
Similarity:	703/1375 - (51%)	Gaps:	170/1375 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFD-SESLTRNLQPHWE 68
            :|..|::.      |||..|..|.||:.:...|.:..|....:: :|.::| :|:|..:.|..|:
plant   223 QQICPEKH------ANIFDKIFFSWMNPLMTLGSKRPLTEKDVW-YLDTWDQTETLFTSFQHSWD 280

  Fly    69 KESKKKNPSLMRLIFKVYG--------W-------QFVPVCILYSLLEMAIHSFQPLLLGGLISY 118
            ||.:|..|.|:|.:....|        |       |||...:|..||: ::....|..:|
plant   281 KELQKPQPWLLRALNNSLGGRFWWGGFWKIGNDCSQFVGPLLLNQLLK-SMQEDAPAWMG----- 339

  Fly   119 FAYGQTTVTKESAYLYAMGI-------VLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCL 176
                         |:||..|       |||..       .:...|..||.|:|.|....|:||.|
plant   340 -------------YIYAFSIFVGVVFGVLCEA-------QYFQNVMRVGYRLRSALIAAVFRKSL 384

  Fly   177 RASASSGEG----LGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGI 237
            |.   :.||    ..|:..::|:.|...........|.:|..|....|...|:.:|:|..||||.
plant   385 RL---TNEGRRKFQTGKITNLMTTDAESLQQICQSLHTMWSAPFRIIIALILLYQQLGVASLIGA 446

  Fly   238 AFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSE 302
            ..:|::.|||...............:..|.|:.||||::.|:..:|.||||.||...:..||..|
plant   447 LLLVLMFPLQTVIISKMQKLTKEGLQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDE 511

  Fly   303 VKAIRGSMSIYAALQCTNM--ISKISLFLSLVAY-VYV---GDLVTAKKVFILSSYYGLLNDSLL 361
            :...|.|.    .|...||  ::.|.:.:::|:: |:.   ||| |..:.|...|.:.:|...|.
plant   512 LSWFRKSQ----LLGALNMFILNSIPVLVTIVSFGVFTLLGGDL-TPARAFTSLSLFAVLRFPLF 571

  Fly   362 HYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETK 426
             ..|..||......||.:|:.|.|     .|||.....||.:    |..:||
plant   572 -MLPNIITQVVNANVSLKRLEEVL-----ATEERILLPNPPI----EPGEPA------------- 613

  Fly   427 CLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGR- 490
             :|.|....|||    .:..:|.:..|:..:..|..|.:||:.|.||::|:.|||||:......
plant   614 -ISIRNGYFSWD----SKGDRPTLSNINLDVPLGSLVAVVGSTGEGKTSLISAILGELPATSDAI 673

  Fly   491 VEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGI 555
            |.:.|.::|..|..|:|..::|:||||...::.::|...:....|..||||||.||.|.:||||:
plant   674 VTLRGSVAYVPQVSWIFNATVRDNILFGSPFDREKYERAIDVTSLKHDLELLPGGDLTEIGERGV 738

  Fly   556 SLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLK 620
            ::|||||.|:::|||||..:|:|:|||||:|:||.||:.:.:||..|.|..|.|:|||:.:..|.
plant   739 NISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAHVGQQVFEKCIKRELGQKTRVLVTNQLHFLS 803

  Fly   621 SVDQLLLLEGGKLTQQGSYEELKD-------------VITHHAALDLEAIEADKQQVKRVLS--- 669
            .||:::|:..|.:.::|:||||..             .:..::..:.|| |||:...:.|.:
plant   804 QVDRIVLVHEGTVKEEGTYEELSSNGPLFQRLMENAGKVEEYSEENGEA-EADQTAEQPVANGNT 867

  Fly   670 ---QVDRTSKQLSK-GEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFV 730
               |:|.:..:.|| |.:|...::..:.   |::..|.||:...|.|..|||..::|.::|..:|
plant   868 NGLQMDGSDDKKSKEGNKKGGKSVLIKQ---EERETGVVSWRVLKRYQDALGGAWVVMMLLLCYV 929

  Fly   731 LARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLL----TLALFLLRTFGFF 791
            |....:.....::|.|.            |....::...::|.::..|    .:.:.|..::...
plant   930 LTEVFRVTSSTWLSEWT------------DAGTPKSHGPLFYNLIYALLSFGQVLVTLTNSYWLI 982

  Fly   792 FMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVD------VNLPQAMMDSLQF 850
            ...|..:..|||.:.|.|:||.|.||:.||.||::|||:.|:.::|      ||:   .|..:..
plant   983 MSSLYAAKKLHDNMLHSILRAPMSFFHTNPLGRIINRFAKDLGDIDRTVAVFVNM---FMGQVSQ 1044

  Fly   851 LVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGH 915
            |:..|.::.||:..:.|.::|   :::|.|.....|...:|.:||::|::|||:|:...:..:|.
plant  1045 LLSTVVLIGIVSTLSLWAIMP---LLVLFYGAYLYYQNTAREVKRMDSISRSPVYAQFGEALNGL 1106

  Fly   916 STIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVI------ 974
            ||||:..|..::........:.|.....:.:.|||......:.:..:.|. :|.||.|:
plant  1107 STIRAYKAYDRMADINGRSMDNNIRFTLVNMGANRWLGIRLETLGGLMIW-LTASFAVMQNGRAE 1170

  Fly   975 NQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPP--LESPKSVNL 1037
            ||..::..:||.::.::.:..:....:|..:..||::.:||||..|.:.|.|.|  :|:.:.
plant  1171 NQQAFASTMGLLLSYALNITSLLTGVLRLASLAENSLNAVERVGNYIEIPPEAPPVIENNRP--- 1232

  Fly  1038 AAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNE 1101
            ...||.:|.::|:|:.:||.|....:|.|::|...|.:|:||||||||||||::.||||:. :.:
plant  1233 PPGWPSSGSIKFEDVVLRYRPQLPPVLHGVSFFIHPTDKVGIVGRTGAGKSSLLNALFRIVEVEK 1297

  Fly  1102 GTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVA 1166
            |.|.||..|:||.||.|||..:.||||.|||||||:|||||||.|.:|..||.:|:...||..:.
plant  1298 GRILIDDCDVGKFGLMDLRKVLGIIPQSPVLFSGTVRFNLDPFGEHNDADLWESLERAHLKDTIR 1362

  Fly  1167 SLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAE 1231
            ....||...:.:.|.|||:|||||:.|:||:||::::||:|||||.||..||.|||:||:.:|..
plant  1363 RNPLGLDAEVSEAGENFSVGQRQLLSLSRALLRRSKILVLDEATAAVDVRTDALIQKTIREEFKS 1427

  Fly  1232 CTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFLKRIASE 1296
            ||:|.|||||:|::|.|.:||:|:|::.||.:|..||..:..:..|:|....|...::|:.:..:
plant  1428 CTMLIIAHRLNTIIDCDKILVLDSGRVQEFSSPENLLSNEGSSFSKMVQSTGAANAEYLRSLVLD 1492

  Fly  1297 SYMRRNRRDS 1306
            :  :|.:.||
plant  1493 N--KRAKDDS 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	425/1328 (32%)
		ABC_membrane	95..360	CDD:294371	75/281 (27%)
		ABCC_MRP_domain1	428..632	CDD:213217	82/204 (40%)
		ABC_membrane	728..994	CDD:294371	67/281 (24%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	114/219 (52%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	436/1375 (32%)
		ABC_membrane	309..570	CDD:279056	78/294 (27%)
		ABCC_MRP_domain1	614..815	CDD:213217	82/204 (40%)
		ABC_membrane	925..1179	CDD:294371	66/272 (24%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	114/219 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720