DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC13

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001323940.1	Gene:	ABCC13 / 815414	AraportID:	AT2G07680	Length:	1426	Species:	Arabidopsis thaliana

Alignment Length:	1331	Identity:	416/1331 - (31%)
Similarity:	676/1331 - (50%)	Gaps:	150/1331 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQSSPK--RESNPFIKANIISK--------W---LFLWMHSVFRKGRREELDASKLYEHLPSFDS 56
            ||:.||  ...:|.|:.:...|        |   .|.::.|:.:.|..::|:...|....|..|.
plant   166 KQAHPKIIPLEDPLIEDDDDQKRIEKNGSWWDLFTFGYIGSIMKHGSVKQLELENLLTLPPEMDP 230

  Fly    57 ESLTRNLQPHWEKE--SKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYF 119
            .:...||...|:.:  :....|||:..|:.||||.:..:.:| .:....|....||||..||.|.
plant   231 FTCCENLLRCWQLQECNNYSTPSLIWSIYGVYGWPYFRLGLL-KVFNDCIGFAGPLLLNRLIKYL 294

  Fly   120 AYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGE 184
            ..|..:   ...|..|:.:...|:..|.:...:.|.:..:..::|.:...::|||||..:.::..
plant   295 EKGSGS---SVGYTLAISLGFISIFKSFLDTQYTFRLSKLKLKLRSSIMSVIYRKCLWVNTANRS 356

  Fly   185 GLG-GQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQA 248
            |.. |:..:.||:|..:........||||..|::..|..||:..||.:..|.|:|..::|||:..
plant   357 GFSEGEIQTFMSVDADRIVNLCNSLHDLWSLPLQIGIALYLLYTQVKFAFLSGLAITILLIPVNK 421

  Fly   249 WAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIY 313
            |.:...||...:..|.:|.|::...|::..|:.:|||.|:..|...:...|.:||..:  :...|
plant   422 WISVLIASATEKMMKLKDERIRKTGELLTNIRTLKMYGWDNWFADWLKETRATEVTHL--ATRKY 484

  Fly   314 AALQCTNMISKISLFLSLVA---YVYVGDLVTAKKVF-ILSSYYGLLNDSLLHYWPMAITTWAQT 374
            ....|....:......||..   :..:|..:.|..|| .|:.:..|:  |.|:.:|..|......
plant   485 LDAWCVFFWATTPTLFSLCTFGLFALMGHQLDAATVFTCLALFNSLI--SPLNSFPWVINGLIDA 547

  Fly   375 LVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDK 439
            .:|.|||.:||          ||       |:..:.....||    ..||...:.....|.:|..
plant   548 FISTRRVSKFL----------CC-------LEHSRDFSIDSG----FTSEDLAVCVEDASCTWSS 591

  Fly   440 PSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQP 504
             ::::.....|:.:|..:..|.||.::|.|||||::||:::|||:..:.|.:.::|.::|..|.|
plant   592 -NVEEDYNLTIKQVSLRVPKGSFVAVIGEVGSGKTSLLNSLLGEMRCVHGSILLNGSVAYVPQVP 655

  Fly   505 WVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALAR 569
            |:..|::||||||.:.::.|||...:.||.||.|:.|:..||...:|::|::|||||:||.||||
plant   656 WLLSGTVRENILFGKPFDSKRYFETLSACALDVDISLMVGGDMACIGDKGLNLSGGQRARFALAR 720

  Fly   570 AVYRQADIYLFDDPLAAVDAQVGKLLMDKC-FHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKL 633
            |||..:|:||.||.|:|||:|||..::.:. ...||:.|.|::.||::|.:...|.:::::.||:
plant   721 AVYHGSDMYLLDDVLSAVDSQVGCWILQRALLGPLLNKKTRVMCTHNIQAISCADMIVVMDKGKV 785

  Fly   634 TQQGSYEELKDVITHHAALDLEAIEADKQQVKRVLSQVDRTS-KQLSKGEEKDPATIQ----DEN 693
            ...||..::...|:...:|               .::.|.:| ..|:|  .|:..:|:    ||.
plant   786 NWSGSVTDMPKSISPTFSL---------------TNEFDMSSPNHLTK--RKETLSIKEDGVDEI 833

  Fly   694 GNA-------EQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEE 751
            ..|       |::.:|.|....|:.| ......|:..::|...||.:|.:...|:::|.|.
plant   834 SEAAADIVKLEERKEGRVEMMVYRNY-AVFSGWFITIVILVSAVLMQGSRNGNDLWLSYWV---- 893

  Fly   752 DRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYF 816
            |:....|..|..:...||:  .:..::...|.|:|.|.|.|..|:.::.:|:.|...:|.|...|
plant   894 DKTGKGVSHYSTSFYLMVL--CIFCIINSILTLVRAFSFAFGGLKAAVHVHNALISKLINAPTQF 956

  Fly   817 FNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDV-----VAVLVIVAIANYWLLIPAAIMV 876
            |:..||||:|||||||:..:|        |||.|::::     |.:|.|:.:.:|   :....::
plant   957 FDQTPSGRILNRFSSDLYTID--------DSLPFILNILLANFVGLLGIIVVLSY---VQVLFLL 1010

  Fly   877 ILLYF------CRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHG-- 933
            :||.|      .:..|...||.|:|::|::|||||:...:|..|.||||:..:    |:.|.|
plant  1011 LLLPFWYIYSKLQVFYRSTSRELRRLDSVSRSPIYASFTETLDGSSTIRAFKS----EEHFVGRF 1071

  Fly   934 ------HQNTNSSALFLYVSANRAFSFWTDL------------ICVIYILAVTFSFLVINQSFYS 980
                  :|.|:.|.:..        |.|..|            :.|:.:|....:|.:   ||.:
plant  1072 IEHLTLYQRTSYSEIIA--------SLWLSLRLQLLGSMIVLFVAVMAVLGSGGNFPI---SFGT 1125

  Fly   981 -GDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQA 1044
             |.||||::.:..||.:....:....|.|..|.||||||:|...|.| .:..|:|  |:.:||..
plant  1126 PGLVGLALSYAAPLVSLLGSLLTSFTETEKEMVSVERVLQYMDVPQE-EVSGPQS--LSDKWPVH 1187

  Fly  1045 GHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDG 1108
            |.:.|.::.|||.......|..::|..|....:|::||||||||||:.|||||. :..|.|.:||
plant  1188 GLVEFHNVTMRYISTLPPALTQISFTIQGGMHVGVIGRTGAGKSSILNALFRLTPVCSGEILVDG 1252

  Fly  1109 LDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLS 1173
            .:|..|.:.:|||.::::||.|.||.|:||.||||.....|..:|..||..|:|..|.|: |||.
plant  1253 KNISHLPIRELRSCLAVVPQSPFLFQGSLRDNLDPLGLSEDWRIWEILDKCKVKAAVESV-GGLD 1316

  Fly  1174 CRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIA 1238
            ..:::.|.:||:|||||:|||||:|:.:::|.:||.|||:|..|..|:..||.::....||:|||
plant  1317 SYVKESGCSFSVGQRQLLCLARALLKSSKILCLDECTANIDVHTASLLHNTISSECKGVTVITIA 1381

  Fly  1239 HRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            ||:.||:|.||:|::|.|.:||.|.|..|||
plant  1382 HRISTVVDLDSILILDRGILVEQGKPQHLLQ 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	409/1319 (31%)
		ABC_membrane	95..360	CDD:294371	68/269 (25%)
		ABCC_MRP_domain1	428..632	CDD:213217	78/204 (38%)
		ABC_membrane	728..994	CDD:294371	83/297 (28%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	99/219 (45%)
ABCC13	NP_001323940.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720