Protein Alignment CG10505 and Abcb8

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_083296.2
• Gene: Abcb8 / 74610
• MGIID: 1351667
• Length: 717
• Species: Mus musculus
• Alignment Length: 609
• Identity: 155/609 - (25%)
• Similarity: 277/609 - (45%)
• Gaps: 86/609 - (14%)

  Fly   715 ALGAPFL---VCLVLSMFV--LARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTV 774
            ||||..:   :.|:|...|  :|:..:..|..|:|      |.|             |:    :|
Mouse   137 ALGAALVNVQIPLLLGQLVEIVAKYTRDHMGSFVS------ESR-------------KL----SV 178

  Fly   775 LLLLTLALFLLRTFGFFFMCL----RISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQN 835
            .|||...:..|.|||:..:..    |:::.:...|:..::|..:.||:|..:|::::|.::|:|.
Mouse   179 QLLLLYGVQGLLTFGYLVLLSHIGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLTTDVQE 243

  Fly   836 VDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKR--IES 898
            ...:....:...|:....|:..||.:::.:..|.:..|::...|.....|.....|.|.|  .|.
Mouse   244 FKSSFKLVISQGLRSCTQVIGSLVSLSMLSPRLTLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQ 308

  Fly   899 LTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNT---------NSSALFLYVSANRAFSF 954
            :.|:.  ...::......|:|:.....:.|:.:.....:         ...|||..:| |.||:
Mouse   309 IARAT--GVADEALGNVRTVRAFAMEKREEERYQAELESCCCKAEELGRGIALFQGLS-NIAFN- 369

  Fly   955 WTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEME-------NNMT 1012
                 |::.........||..|....||:       |:.::..|...|..|.:.       ..::
Mouse   370 -----CMVLGTLFIGGSLVAGQQLKGGDL-------MSFLVASQTVQRSMASLSVLFGQVVRGLS 422

  Fly  1013 SVERVLEYAQTPSEPPLESPKSVNLAAEWPQ---AGHLRFQDLRMRY--SPGDEDILRGLNFESQ 1072
            :..||.||.......||.....:      |.   .|.:.||::...|  .|| .::|:....:..
Mouse   423 AGARVFEYMALSPVIPLTGGYCI------PNKDIRGSITFQNVTFSYPCRPG-FNVLKDFTLKLP 480

  Fly  1073 PMEKIGIVGRTGAGKSSIIQALFRLALNE-GTIEIDGLDIGKLGLHDLRSR-ISIIPQDPVLFSG 1135
            ..:.:.:||::|.||:::...|.|....| |::.:||.|:..|....||.: |..|.|:||||:.
Mouse   481 SGKIVALVGQSGGGKTTVASLLERFYDPEAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFAT 545

  Fly  1136 TLRFNLDPFD--EKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAIL 1198
            |:..|: .|.  :.|||.:::|..:....:.::|...|.|..:.:.|:..|.||:|.:.:|||::
Mouse   546 TIMENI-RFGKLDASDEEVYTAAREANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALI 609

  Fly  1199 RQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGA 1263
            :|..||::||||:.:|.|::.::||.:....|..|||.|||||.||....|::||..||:.|.|.
Mouse   610 KQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGT 674

  Fly  1264 PHKLLQRKDGALLKLVNQN--DAT 1285
             |:.|.:|.|...:|:.:.  ||:
Mouse   675 -HEELLKKGGLYSELIRRQTLDAS 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	149/588 (25%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217
		ABC_membrane	728..994	CDD:294371	56/282 (20%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	76/224 (34%)
Abcb8	NP_083296.2	MdlB	116..695	CDD:224055	153/605 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	695..717		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000