Protein Alignment CG10505 and abcc12

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_009301629.1
• Gene: abcc12 / 568482
• ZFINID: ZDB-GENE-050517-25
• Length: 1368
• Species: Danio rerio
• Alignment Length: 1372
• Identity: 459/1372 - (33%)
• Similarity: 722/1372 - (52%)
• Gaps: 175/1372 - (12%)

  Fly    13 SNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLT-RNLQPHWEKESKK--- 73
            |:|...|...|...|.||..:..:..|..||...|:  |...|...:. ...|..|::|..:
Zfish    66 SHPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLF--LSPHDGAHINGERFQRLWDEEVARVGL 128

  Fly    74 KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGI 138
            :..||..:|.:....:|:     .|.|...:.:|...:...::.|........::.|..::.:|:
Zfish   129 EKASLSAVIMRFQKTRFI-----VSFLASVMFAFAVFVGPSILVYEILNYVEQSEPSTVVHGVGV 188

  Fly   139 VLCSLVTSLVFHPFMFYVFAV----GTRVRLACAGLVYRKCLRASASSGEGLGGQAISVMSIDLS 199
            .:...:|......|...::||    ..||:.|.:.|.::|.:...:.:...: |:.|:|::.|
Zfish   189 CVALFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKIISLRSLTTITV-GETINVLTSD-- 250

  Fly   200 QFDLTFYFFHDLWKGPVEACIFG-YLMTRQV-------------GWTSLIGIAFIVILIPLQAWA 250
                .:..|        :|.||| :|:...|             |:|:||||...:|.:|:|...
Zfish   251 ----GYRLF--------DAVIFGTFLLCVPVLLIICIIYACFILGYTALIGILVYLIFLPIQFSI 303

  Fly   251 AKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSE---------VKAI 306
            |:....|..|:....|.||:.|||::..|::|||||||:||.:.|..:|::|         |:::
Zfish   304 ARLIGVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGYVQSL 368

  Fly   307 RGSMSIYAALQCT--NMISKISLFLSLV---AYVYVGDLVTAKKVF-ILSSYYGLLNDSLLHYWP 365
            ..|::.......|  ..|...||.|.|:   ||..:.       || .:....|||        |
Zfish   369 NSSLTTIVPTLATIVTFIVHTSLKLPLLPSTAYTIIA-------VFNCMRMSMGLL--------P 418

  Fly   366 MAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSF 430
            .::...|:..|:..|:...:|                    .:.||    |.|...::....|..
Zfish   419 FSVKAVAEAKVALTRLKRIML--------------------VQNPK----GYLTQDKNMDLALVM 459

  Fly   431 RKVSASW----DKPSIKQPR------------KPHIEGISFHINAGQFVGIVGNVGSGKSTLLHA 479
            .|.:.||    ||.:.:.|.            :|.:..||..::.|..:|:.|||||||::|:.:
Zfish   460 EKATFSWSPTDDKNTSQMPENPSQNGKHKAESQPSLRNISLTLSKGSLLGVCGNVGSGKTSLISS 524

  Fly   480 ILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPR 544
            ||.::.|:.|.|..:|.::|.:||.|:|.|::|:|||..|.::|.||.:|::||.|..||.:||.
Zfish   525 ILEQMHLLSGSVSANGTLAYVSQQAWIFHGTVRDNILMGEPFDEARYASVINACCLKPDLAILPY 589

  Fly   545 GDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMR 609
            ||.|.:|||||:||||||.|::||||||...||:|.||||:||||.|||.:.::|..:.|.||..
Zfish   590 GDQTEIGERGINLSGGQKQRVSLARAVYSNRDIFLLDDPLSAVDAHVGKHIFEECIKKELKGKSV 654

  Fly   610 ILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL-------KDVITH-HAALDLEAIEADKQQVKR 666
            |||||.:|.|:..|:::||:.|::.:.|::.:|       ..:||: |...:.|..:: |.|.:.
Zfish   655 ILVTHQLQYLEFCDEVMLLDNGEIKEAGTHSDLMKTKGRYSQLITNVHLEQNNERADS-KPQTEH 718

  Fly   667 VLSQVDRTSKQLSKG--------EEKDPATIQDENGNAE-----QQL-------QGAVSYDTYKA 711
            ..|:.....:..:.|        .::.|||.:....::|     .||       :|:|::.||..
Zfish   719 NDSEQTNPDEPKANGIENPAFDMSDEKPATNETPKDSSETKGKKDQLVTREVAQEGSVTWRTYHQ 783

  Fly   712 YFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRT---------- 766
            |.:|.|...|:.||:.:|.|..|..|..:.::|.|.    |:|..:.....||..
Zfish   784 YCQAAGGYILLFLVVLLFTLLVGSTAFSNWWLSYWL----DQGSGNNSSSNATSNSGNISENPDL 844

  Fly   767 ---KMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNR 828
               :||  |.|:::..:.|.:|:.:.|..:.||.|..|||.::..|:.:.|.||:..|:||::||
Zfish   845 SFYQMV--YGVIIIAMIVLSILKGYTFTKVTLRSSSKLHDTMFKRILGSPMSFFDTTPTGRLVNR 907

  Fly   829 FSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYI--GASR 891
            ||.|...||..||..|.:.|||.:.|...|:.:.|...:|||  |::::.|.|...||:  .:.|
Zfish   908 FSKDQDEVDAVLPFNMENFLQFCLIVTFTLLTICIVFPFLLI--AVVILGLIFATILYVFQRSIR 970

  Fly   892 SLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWT 956
            .:||:|:::|||..|.|..|..|.|||.:.|...|..:.|....:.||:...|:.:..|..|||.
Zfish   971 HMKRMENVSRSPWISLTTSTIQGLSTIHAYDKRQQYIERFKMLSDNNSNHFMLFNAGTRWLSFWL 1035

  Fly   957 DLICVIYILAVTFSFLVI--NQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLE 1019
            |::.....|.|:. |:|:  |::......|||::.::.|..:.|:.:|.:.|:|...|||||:||
Zfish  1036 DVLSATVTLIVSL-FVVLSPNETINPSLKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLE 1099

  Fly  1020 Y-AQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRT 1083
            | ....||.| ...|..|:.|.|||.|.:.|::..|||......:|..||...:|.||:||||||
Zfish  1100 YITSCVSEGP-RRVKDANIPAGWPQEGTITFKNYSMRYRDNTPIVLDNLNITIRPGEKLGIVGRT 1163

  Fly  1084 GAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEK 1147
            |:||||:..|||||| ..||||.||.:||.||||.||||::|:||||||||.||:|:|||||:..
Zfish  1164 GSGKSSLGVALFRLAEPAEGTILIDDMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPFNNY 1228

  Fly  1148 SDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATAN 1212
            .||.||.||:...:|..::.|...|...:.:.|.|||:|:|||:|:|||:||.::::::|||||:
Zfish  1229 KDEELWLALEKTYMKDTISKLPEKLQSPVVENGENFSVGERQLMCMARALLRNSKIILLDEATAS 1293

  Fly  1213 VDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKD---GA 1274
            :|:|||.|||.||:..|..||:||||||::||:::|.:||||.|:::||..|..|:||.:   .:
Zfish  1294 IDSETDSLIQHTIRDGFQHCTMLTIAHRINTVLESDRILVMDQGKVIEFDPPQDLIQRPNSLFAS 1358

  Fly  1275 LLKLVNQ 1281
            ||...||
Zfish  1359 LLAAANQ 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	453/1355 (33%)
abcc12	XP_009301629.1	PLN03130	68..1364	CDD:215595	456/1367 (33%)