DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc6a

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_009300481.1	Gene:	abcc6a / 566555	ZFINID:	ZDB-GENE-050517-18	Length:	1507	Species:	Danio rerio

Alignment Length:	1334	Identity:	460/1334 - (34%)
Similarity:	700/1334 - (52%)	Gaps:	121/1334 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKK------ 73
            |...|:.:||.||.|...:..||.|..|.|..|:.......||.:..:|:..|..:..|
Zfish   205 PVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISDLEEEWTAKRTKLQQQEN 269

  Fly    74 ----------KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGG-------------- 114
                      :.|...:|:.|:...|....|:|.:|    ..||.|..|.|
Zfish   270 HMSTSAALGSRLPDQAQLLRKIQKEQSSGFCLLRTL----ARSFGPYFLTGTLCLIVHDVFMFSV 330

  Fly   115 ------LISYFAYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYR 173
                  |:.:.....|.:.|  .|.||..:.|.|.:.|:..|.:.:..|.||.||:.|..|||||
Zfish   331 PQVLSLLLGFMKDEDTPLWK--GYFYATLMFLLSCLQSVFNHQYTYTCFTVGMRVKTAVMGLVYR 393

  Fly   174 KCLRASASSGEGLG-GQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGI 237
            |.|..::|:..... |:.::::|.|..:......:|:.:|..|:|..:..:.:.:.:|.::|.||
Zfish   394 KSLVMNSSARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEVTLCLFFLWQHLGPSALAGI 458

  Fly   238 AFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSE 302
            |.::.:.||..:.|:..:.......|:.|.||||||||:..|:::|.|||||:|...:...|:.|
Zfish   459 ATVIFIFPLNGFIARKRSKLQEIQMKYMDGRVKLMNEILNGIKILKFYAWEKAFLEQVLGYREKE 523

  Fly   303 VKAIRGSMSIYA-ALQCTNMISKISLFLSLVAYVYVGD--LVTAKKVFILSSYYGLLNDSLLHYW 364
            :|.::.|..:|: :|...|..|.:..|.....||.:.|  ::.|:|:|:..:...:|...|...
Zfish   524 LKTLKKSQILYSVSLASFNSSSFLIAFAMFGVYVLIDDKNVLDAQKIFVSMALINILKTPLSQL- 587

  Fly   365 PMAITTWAQTLVSARRVVEFLLQVE-KPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCL 428
            |.|::|..|.|||.:|:.:||.|.| ||       ||...|               ..:|:...:
Zfish   588 PFAMSTTMQALVSLKRLGKFLCQDELKP-------DNVARE---------------SFKSDVDGV 630

  Fly   429 SFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEV 493
            .|...:.||.|..     .|.::.||..:..|..|.:||:||||||:||.|:|||.|...|.|.|
Zfish   631 VFDNGTFSWSKDG-----PPCLKRISVKVPCGSLVAVVGHVGSGKSSLLSAMLGETEKRSGTVSV 690

  Fly   494 HGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLS 558
            .|.|:|..||.|:...|:::||||..:.:|..|:.|:.||.|..||:.||.||||.:||:|::||
Zfish   691 KGSIAYVPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLPDLDNLPAGDATEIGEKGLNLS 755

  Fly   559 GGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRILVTHHVQLLKS 621
            ||||.|::|||||||:.|:||.||||:||||.||:.:.:|..  ..:|..|.|:||||.:..|..
Zfish   756 GGQKQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGPKGILRDKTRVLVTHGMSFLPQ 820

  Fly   622 VDQLLLLEGGKLTQQGSYEEL-------KDVITHHAALDLEAIEADKQQVKR-----VLSQV--- 671
            .|.:|:|..|:::::|||:||       .|.|  |...:.|..|...:.::|     |...|
Zfish   821 ADLILVLVDGEISERGSYQELLNRNGAFADFI--HTFANSERKECFSEALQRGSRKSVRLSVTDY 883

  Fly   672 -----DRTSKQLSKGEEK----DPATIQDEN---------GNAEQQLQGAVSYDTYKAYFRALGA 718
                 |.:.:||..|:..    :|....||:         ...::...|.|..:.|..|||.:|.
Zfish   884 MPFSRDLSQEQLIGGDTNSIAIEPLPDSDEDHIPEDLGKLTKVDKARIGRVKLEMYIEYFRTIGL 948

  Fly   719 PFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALF 783
            |.::.:|. ::...:......:.::|.||......|.....|     .|:.::..:.....:::|
Zfish   949 PLIISIVF-LYAFQQAASLSNNYWLSLWADQPVINGTQLNTD-----LKLGVYGALGFAQGISIF 1007

  Fly   784 LLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSL 848
             ..|......|:..|..||..|.:.::.:.|.||.:.|||.:||||:.:|..:|..:|..:...|
Zfish  1008 -GTTVAISLGCIIASRHLHLDLLNNVLHSPMSFFESTPSGNLLNRFAKEIDAIDNMIPDGLKMML 1071

  Fly   849 QFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFH 913
            .:...:..|.:||.:|..:..:....||.|..|.::.|:..|..|:|:||::|||||:|.|:|..
Zfish  1072 SYFFKLTEVCIIVLMATPFAAVIILPMVFLYGFIQSFYVATSCQLRRLESVSRSPIYTHLNETVQ 1136

  Fly   914 GHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSF 978
            |.|.||:.:...:.....:...:.|.:|.|....|.|......:.:....:||.:...::...:.
Zfish  1137 GASVIRAFNEQSRFIMGANHKVDHNQTAYFPRFIATRWLGVNLEFLGNGIVLAASILSVMAKGTL 1201

  Fly   979 YSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQ 1043
            ..|.||||::.|:.:.....|.:|...::|||:.|||||.|||.||.|... |.:..:|...|||
Zfish  1202 SPGMVGLAVSHSLQVTGFLSWIVRSWTDVENNIVSVERVKEYADTPKEAAW-SIEGSSLPPSWPQ 1265

  Fly  1044 AGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTIEID 1107
            .|.:.|||..::|..|.|..|:|::......|||||||||||||||:...:|| |...:|.|.||
Zfish  1266 TGTIEFQDYGLQYRKGLELALKGISVHIHEREKIGIVGRTGAGKSSLALGIFRILEAAKGEIYID 1330

  Fly  1108 GLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGL 1172
            |::|.::|||||||||:|||||||||||:||.|||||:..|||.:|:||:...||..|:.|...|
Zfish  1331 GINIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFNAYSDEEVWNALELAHLKNFVSELPDKL 1395

  Fly  1173 SCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTI 1237
            :....:||.|.|:|||||||||||:||:.:|||:|||||.:|.|||.|||.||:::|.:|.||||
Zfish  1396 NHECSEGGENLSLGQRQLVCLARALLRKTKVLVLDEATAALDLETDTLIQSTIRSQFEDCAVLTI 1460

  Fly  1238 AHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRK 1271
            ||||:|:||...|:|||.|.:||..:|..|:.::
Zfish  1461 AHRLNTIMDYTKVIVMDKGHVVEMDSPSNLIAKR 1494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	459/1329 (35%)
		ABC_membrane	95..360	CDD:294371	80/288 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	94/205 (46%)
		ABC_membrane	728..994	CDD:294371	66/265 (25%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	125/219 (57%)
abcc6a	XP_009300481.1	MRP_assoc_pro	5..1506	CDD:188098	460/1334 (34%)
		ABC_membrane	317..584	CDD:279056	73/268 (27%)
		ABCC_MRP_domain1	630..831	CDD:213217	94/205 (46%)
		ABC_membrane	955..1218	CDD:279056	67/269 (25%)
		ABCC_MRP_domain2	1267..1487	CDD:213211	125/219 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660