DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcb10

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	686	Identity:	164/686 - (23%)
Similarity:	289/686 - (42%)	Gaps:	133/686 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 KQLSKGEEKDPAT------------IQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSM 728
            :.|....::.||.            ::.|.|    :|..||.:             ..|..|::|
Mouse   104 RDLGNDSQRRPAATGRSEVWKLLGLVRPERG----RLSAAVGF-------------LAVSSVITM 151

  Fly   729 ---FVLARGCQAVMDIFISRWATWEEDRGY-DSVDDYEATRTKMVIWYTVLLLLTLA-----LFL 784
               |.|.|    ::|:..:     ....|| ||:       |::....|.:.|...|     ::|
Mouse   152 SAPFFLGR----IIDVIYT-----NPSEGYGDSL-------TRLCAVLTCVFLCGAAANGIRVYL 200

  Fly   785 LRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDI----QNVDVNLPQAMM 845
            :::.|     ..|...|...|:..|:|..:.||:...:|.::||.|||.    ::|..||...:.
Mouse   201 MQSSG-----QSIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLR 260

  Fly   846 DSLQFLVDV-VAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTN 909
            ...|..|.| :...|..::|.:.|.:...|.|:.:.:        .|.|:::...|:..:...|.
Mouse   261 AGAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIY--------GRYLRKLSKATQDSLAEATQ 317

  Fly   910 QTFHGHSTIRSMDA----MPQLEQTFHGH-----QNTNSSALFLYVSANRAFSFWTDLICVIYIL 965
            ........||::.|    |.::|: :.|.     |.....||     |...|.....|...:.:|
Mouse   318 LAEERIGNIRTIRAFGKEMTEVEK-YTGRVDQLLQLAQKEAL-----ARAGFFGAAGLSGNLIVL 376

  Fly   966 AVTF-----------------SFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTS 1013
            :|.:                 |||:     |:..|||:|....:..          :|:...:.:
Mouse   377 SVLYKGGLLMGSAHMTVGELSSFLM-----YAFWVGLSIGGLSSFY----------SELMKGLGA 426

  Fly  1014 VERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDE-DILRGLNFESQPMEKI 1077
            ..|:.|..:  .:|.|...:.:.|..:..| |.|.|:::...|....| .:.:..:.........
Mouse   427 GGRLWELLE--RQPRLPFNEGMVLDEKTFQ-GALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVT 488

  Fly  1078 GIVGRTGAGKSSIIQALFRL-ALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNL 1141
            .:||.:|:|||:::..|.|| ..|.||:.:||.||.:|....|||:|..:.|:|||||.::..|:
Mouse   489 ALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENI 553

  Fly  1142 ----DPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNR 1202
                |.....:.:.:..|.:.....:.:.|...|....:.:.|...|.||:|.:.:|||:|:..:
Mouse   554 AYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPK 618

  Fly  1203 VLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKL 1267
            :|::||||:.:|.|.:.|:||.:.......|||.|||||.|:.:.:.|.|:|.|:|.|.|...:|
Mouse   619 ILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEEL 683

  Fly  1268 LQRKDGALLKLVNQNDATTVKFLKRIASESYMRRNR 1303
            |.:.:|...||:|:.     .||....:|.::...|
Mouse   684 LLKPNGLYRKLMNKQ-----SFLSYNGAEQFLEPAR 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	154/649 (24%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217
		ABC_membrane	728..994	CDD:294371	65/305 (21%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	72/224 (32%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	157/659 (24%)
		ABC_membrane	142..403	CDD:279056	62/313 (20%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	76/239 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000