DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc9

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_005164758.1	Gene:	abcc9 / 561160	ZFINID:	ZDB-GENE-050517-23	Length:	1583	Species:	Danio rerio

Alignment Length:	1403	Identity:	407/1403 - (29%)
Similarity:	695/1403 - (49%)	Gaps:	182/1403 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTR--NLQPHWEK-----ESK 72
            ||:  |::||..:.||:.:.....:..::..|:.: || ....:||.  .|:..:|:     |..
Zfish   220 PFV--NLLSKATYWWMNPLIIGAHKRPIELKKIGK-LP-IAMRALTNYLRLKDSYEEQRQNTEDP 280

  Fly    73 KKNPSLMRLIFKVYGWQFVPVCILYS--------LLEMAIHSFQPLLLGGLISYF----AYGQTT 125
            :|:||:.:.:::.:|..     ||.|        ||..|    .||.:.|::.:.    ...:|.
Zfish   281 EKSPSIWKSMYRAFGGS-----ILLSSTFRYMADLLGFA----GPLCISGIVEHLHNSTEIDRTN 336

  Fly   126 VTKESAY-LYAMG-------------IVLCSLVTSLVFHPFMFYV-FAVGTRVRLACAGLVYRKC 175
            .|....: :|.|.             ::..:||....|....:|| ...|..:|.|...::|.|.
Zfish   337 KTGNMTFGVYFMSSTELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGINLRGALLAMIYNKI 401

  Fly   176 LRASASS---GEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGI 237
            ||.|.|:   ||...||..::::|:.:|.....:...:||..||:..:...|:...:|.::|||.
Zfish   402 LRLSTSNMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGA 466

  Fly   238 AFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSE 302
            ..|::|.|:|...|...|.....:..:...|:|...||:..|:::|:||||..|...:...|..|
Zfish   467 GVILLLAPVQYLIATKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKE 531

  Fly   303 VK-----AIRGSMSIY--AALQCTNMISKISLFLSLVAYVYV-GDLVTAKKVFILSSYYGLLNDS 359
            :.     |:..||||:  ||:....:::      :.|.:.|: .|.::..|.|...:.:.:|...
Zfish   532 LTSLKTFALHTSMSIFMNAAIPIAAVLA------TFVTHAYIEEDRLSPAKAFASLALFHILVTP 590

  Fly   360 LLHYWPMAITTWA-QTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQS 423
            |  :....:..:| :.|||.:::.|| ||.::..::|....:..:.|:.        |:.:..|.
Zfish   591 L--FLLSTVVRFAVKALVSVQKLSEF-LQSDEIGDDSWRNGDMCMSLEV--------GKKYKYQG 644

  Fly   424 ETKCLS--FRKVSASWDKPSIKQPRKPHIEGISFHIN---------------------AGQFVGI 465
            :||.::  .|....::::|..:|.|....|.::..:|                     .||...|
Zfish   645 DTKAINRKGRYRMDNYEQPVRRQLRPSETEDVAVQVNDGFFTWGSNLSTLSDINIRIPTGQLTMI 709

  Fly   466 VGNVGSGKSTLLHAILGEIELMQGRV--------------EVHGR---------------ISYAA 501
            ||.||.|||:||.|:|||::.:.|:|              .:.|.               ::||.
Zfish   710 VGQVGCGKSSLLLAMLGEMQTISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAYAT 774

  Fly   502 QQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIA 566
            |:.|:...::.|||.|...:.::||:||:.||.|..|::|||.||.|.:|||||:|||||:.||.
Zfish   775 QKSWLLNATVEENITFGSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRIC 839

  Fly   567 LARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLL--DGKMRILVTHHVQLLKSVDQLLLLE 629
            :|||:|:..:|...|||.:|:|..:...||.:...:.|  |.:..:||||.:|.|...|.::.::
Zfish   840 VARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAMK 904

  Fly   630 GGKLTQQGSYEELKDVITHHAALDLEAIEADKQQVKR----------VLSQVDRTSKQLSKG--- 681
            .|.:.::|:   |||:.||    |:|..|..|..:.|          :.||.....|.|.:.
Zfish   905 DGSVLREGT---LKDIQTH----DVELYEHWKTLMNRQDQELEKDTDLESQTTLERKTLRRAFYS 962

  Fly   682 -EEKDPATIQDENGNAEQQLQGAVSYDTYK---------AYFRALGAPFLVCLVLSMFVLARGCQ 736
             |.|:....:||....|::....:|..|.:         ..:.:.|...:|.|::|..:......
Zfish   963 REAKNHVDDEDEEEEVEEEDDDNMSTTTSRRSKIPWKMCCCYLSSGGFLMVFLMVSSKLAKHSVM 1027

  Fly   737 AVMDIFISRWATWEE------DRGYDSVDDYEATR----TKMVIWYTVLLLLTLALFLLRTFGFF 791
            ..:|.:::.|.:...      :..::...:.:||:    ...|..:.:|....:||.|:.:....
Zfish  1028 VAIDYWLAAWTSSNPHNQSFVNSSFNHTLNDDATQIAEHRSYVPVFIILCAAAIALCLITSLTVE 1092

  Fly   792 FMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLP---QAMMDSLQFLVD 853
            |:.:..:..||..|.:.||.|.:.||:..|.|::|||||:|...:|.::|   :::..|....:.
Zfish  1093 FLGVAAATNLHHNLLNKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTLLCLS 1157

  Fly   854 VVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTI 918
            .:.|:..|..|....|:|.|   :..||.:..:..||:.|:.::..|:.|:..|.::|..|.:||
Zfish  1158 AIGVIAFVTPAFLIALVPLA---VAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTI 1219

  Fly   919 RSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDV 983
            |:.....:.:|......:||::|.....:|||.....||.:..:.:|  |.:...|..:..||.|
Zfish  1220 RAFRHEARFKQRMLELTDTNNTAYLFLSAANRWLEVRTDYLGAVIVL--TAAVAAIWSTSPSGLV 1282

  Fly   984 GLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLR 1048
            ||.:|.::||.....|.:|..|::|..|.:|::|..:..|.||....|.....:..:|||.|.:.
Zfish  1283 GLGLTYALTLTNYLNWVVRNLADLEVQMAAVKKVNSFLSTESENYEGSMDVSQVPEDWPQHGEIT 1347

  Fly  1049 FQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIG 1112
            ..||.:||....:.:|:.:|....|.:|:||.||||:||||:..|.|.:. :.||.|.|||:||.
Zfish  1348 IHDLCVRYDSMLKPVLKHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIVIDGIDIC 1412

  Fly  1113 KLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQ 1177
            ||.|..||||:|||.||||||||::|.||||....:|:.||.||:..:||..|.:|.|||...:.
Zfish  1413 KLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPGGLDAVVT 1477

  Fly  1178 DGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLH 1242
            :||.|||:|||||.|||||.:|::.:|:||||||::|..|:.::|:.:.|.||:.||:||||.:.
Zfish  1478 EGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHLVS 1542

  Fly  1243 TVMDNDSVLVMDAGQIVEFGAPHKLLQRKD---GALLK 1277
            ::::.:.|||..:|.:||..:...||.::|   |.|::
Zfish  1543 SILEAEQVLVFSSGILVENDSAINLLAQEDSLFGILVR 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	402/1389 (29%)
		ABC_membrane	95..360	CDD:294371	74/302 (25%)
		ABCC_MRP_domain1	428..632	CDD:213217	80/257 (31%)
		ABC_membrane	728..994	CDD:294371	67/278 (24%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	105/219 (48%)
abcc9	XP_005164758.1	CFTR_protein	223..1575	CDD:273530	403/1391 (29%)
		ABC_membrane	304..591	CDD:294371	71/296 (24%)
		ABCC_SUR1_N	678..907	CDD:213257	75/228 (33%)
		ABC_membrane	1045..1300	CDD:294371	67/259 (26%)
		ABCC_SUR2	1269..1583	CDD:213255	133/312 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650