DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc10

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_005155817.1	Gene:	abcc10 / 556709	ZFINID:	ZDB-GENE-050517-24	Length:	1548	Species:	Danio rerio

Alignment Length:	1375	Identity:	447/1375 - (32%)
Similarity:	701/1375 - (50%)	Gaps:	178/1375 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ANIISKWLFLWMHSVFRKGRREELD-ASKLYEHLPS-FDSESLTRNLQPHWEK----------ES 71
            ::::|:.|:||::.:..:|:|.||. .|.::| ||| ..::|:||.....|||          |.
Zfish   231 SSLLSRLLYLWLNPLLNRGKRGELGRPSDVFE-LPSRLRTKSVTRRFYQCWEKCLHSRALERPER 294

  Fly    72 KKKNP--------------------------SLMRLIFKVYGWQFV---PVCILYSLLEMAIHSF 107
            ..:.|                          .|::::.|.:|.::.   .:.::.|:|..|
Zfish   295 PDRRPRGNLQDNSWSEAQPERICEGEAEHEVKLLQVLHKAFGLRYYLLGGLKLVASMLAFA---- 355

  Fly   108 QPLLLGGLISYFAYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVY 172
            .|||||||:.:.......::|  ....|:|:...:.:.:|:.:.|::.|..|....|.|....:|
Zfish   356 GPLLLGGLVGFMETEGAPLSK--GVWCAVGLFASTFLAALLKNIFVYEVSKVALEARAAVISTIY 418

  Fly   173 RKCLRASASSGEGLG-GQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIG 236
            .|.|:.:|.|..... |:.::.||.|..:....|..||::|..|.:..:..||:..|||...|.|
Zfish   419 CKALKVNAPSLARFNMGEVVNFMSTDTDRVVNFFNSFHEVWSLPFQFVLALYLLYLQVGVAFLGG 483

  Fly   237 IAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQS 301
            :...|:|:||....|...........:|:|.|||||.||:..|:|:|.|.||:.|.:.|...|:.
Zfish   484 VGVAVLLVPLNKVLASRILENNKHMLQHKDGRVKLMTEILFGIRVLKYYNWEEHFTQKIEEARKK 548

  Fly   302 EVKAIR-----GSMSIYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLL 361
            |:..::     .::.:|.......:||    .|:.:.||.:|:.:||.|||...:..|:| ...|
Zfish   549 ELHHLKLLKYLDAVCVYTWAALPVVIS----ILTFITYVLLGNNLTAAKVFSTLALVGML-ILPL 608

  Fly   362 HYWPMAITTWAQTLVSARRVVEFLLQVEKPTE---ESCCRDNPGLELDAEKPKPAQSGRLHCVQS 423
            :.:|..:....:..||..|:..||...::...   ...|.::|        |...|     .||:
Zfish   609 NAFPWVLNGTLEAKVSLDRIQRFLAVQDQDLSVYYSQVCPEDP--------PSAVQ-----MVQA 660

  Fly   424 ETKCLSFR-KVSASWDKPSI--------KQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHA 479
                 ||. |.|...|..||        ..||..::..::.::..|..|.:||.||.|||:||.|
Zfish   661 -----SFSWKQSEEADSVSIPDDITEEGSPPRSFYLHALNLNVKMGSLVVVVGKVGCGKSSLLAA 720

  Fly   480 ILGEIELMQGRVEVHGR---ISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLEL 541
            |.||:....|.|.|.||   ...|.|:||:...::::||||...|:...|::|:.||.|..||.:
Zfish   721 ITGELTRCGGEVFVQGREQGFGLAVQEPWIQHATVQDNILFGRDYDNMFYQSVIQACALADDLNI 785

  Fly   542 LPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDG 606
            ||.||.|.|||.|::||||||:|:|||||||...:|||.|||||||||.|...||:||...:|..
Zfish   786 LPGGDQTEVGENGVTLSGGQKSRLALARAVYMDKEIYLLDDPLAAVDADVAHHLMEKCILGILKD 850

  Fly   607 KMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLEAIEADKQQVKRVLSQV 671
            |.|||.||.::.:...|.::|::.|.:.:.|:..|                         |||.|
Zfish   851 KTRILCTHRIEFVDKADVVVLMDNGMIVKTGAPSE-------------------------VLSLV 890

  Fly   672 --DRTSKQLSKGEEKDPATIQD------------ENGNAEQQLQGAVSYDTYKAYFRALGAPFLV 722
              .:.||..|..:|||.|..::            |....||:..|.:|:..|::|::|:|....|
Zfish   891 KGPKDSKNSSNAKEKDSAGSEEMEASEPELKAELEMFGEEQKQMGTLSWAVYRSYWKAVGGCMAV 955

  Fly   723 CLVLSMFVLARGCQAVMDIFISRWATWEED------------------------------RGYDS 757
            .::|::| |.:..:.|.|.::|.|.:..:|                              ||.:|
Zfish   956 AVLLALF-LMQASKNVSDWWLSHWISHMKDNMTELVSVSATPLLMLSFLSPGRLVFNAPARGSES 1019

  Fly   758 VDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPS 822
            ..:..:.....:..|..|..........|.|.|.:..:..:..:|.:|...:::|.|.||:..|.
Zfish  1020 SGNMSSELKFYMTVYGSLAAANTVFTAARAFLFAYGAICAATVVHKRLLSSVLKATMTFFDTTPL 1084

  Fly   823 GRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYI 887
            ||:||||||||.:||.:||..:...|..:..::.:|::::....|:|:|...:..|.|..:..|.
Zfish  1085 GRILNRFSSDIYSVDDSLPFVLNILLANVFGLLGMLIVMSYGLPWVLLPLVPLGALYYQTQCFYR 1149

  Fly   888 GASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAF 952
            .:||.|||:.|||.||:|||.::|..|.||:|......:.|:........|...||   ::|.|.
Zfish  1150 YSSRELKRLCSLTLSPVYSHFSETLSGLSTVRGSGHTTRFEEENERRLEQNQRCLF---NSNAAM 1211

  Fly   953 SFWTD----LICVIYILAVTFSFLVINQ--SFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNM 1011
            . |.|    :|.|..:..::...::.:|  |...|.|||:::.::::..:....:...|:.|..:
Zfish  1212 Q-WLDIRLQMIAVTVVTGISVIAVIQHQLKSIDPGLVGLSLSYALSITNLLSGLIFSYAQTEMQL 1275

  Fly  1012 TSVERVLEYAQT-PSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPME 1075
            .|:||..||:.: |.||   ...|:.:...||:...:.|.|:.:.|.||..:.|.|::.|..|.|
Zfish  1276 VSIERTEEYSTSIPQEP---QQASLEVLDRWPERARVEFVDVVLSYRPGLPNALDGVSVEVLPGE 1337

  Fly  1076 KIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRF 1139
            |||||||||:||||:..||||:. ||:|.|.:||:||..:.|.||||:::||||||.|||.::|.
Zfish  1338 KIGIVGRTGSGKSSLFLALFRMVELNQGQILLDGVDISSVRLSDLRSKLAIIPQDPFLFSSSVRE 1402

  Fly  1140 NLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVL 1204
            ||||.....|..|..||:...| .:|....|||...:.:.|.:.|:|||||:|||||:|.:..:|
Zfish  1403 NLDPHGRHPDYRLLEALEQCHL-GNVVQRNGGLDSEVGERGKSLSVGQRQLLCLARALLTEANIL 1466

  Fly  1205 VMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            .:|||||:||.:||:|:|:||:.||.:.|||||||||:|:||:|.||||.||::|||.:|..|.|
Zfish  1467 CIDEATASVDQKTDMLLQKTIREKFKDKTVLTIAHRLNTIMDSDKVLVMHAGKVVEFDSPATLCQ 1531

  Fly  1270 RKDGALLKLV 1279
            |:|.|..||:
Zfish  1532 REDSAFQKLL 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	440/1362 (32%)
		ABC_membrane	95..360	CDD:294371	78/270 (29%)
		ABCC_MRP_domain1	428..632	CDD:213217	94/215 (44%)
		ABC_membrane	728..994	CDD:294371	78/301 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	114/219 (52%)
abcc10	XP_005155817.1	SunT	248..1531	CDD:331423	437/1346 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650