DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10505 and l(2)03659

DIOPT Version :9

Sequence 1:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster


Alignment Length:1332 Identity:532/1332 - (39%)
Similarity:828/1332 - (62%) Gaps:70/1332 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SKQSSPKRE------SNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRN 62
            |:.:|.:.|      .||..::|.||...|.:...:||||.|:.||::.||..|....|:.|...
  Fly    73 SENNSAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNR 137

  Fly    63 LQPHWEKESKK--KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTT 125
            |...||:|.|.  ::|||:|.:.:|:|||.....:...::|:.:.:.||:.|..|||||: |:..
  Fly   138 LCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFS-GEPD 201

  Fly   126 VTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQ 189
            ......| ||:..::.|.:|.::..|..|.:..|..::|:|...:::||.||.:..: |:...|.
  Fly   202 AANAGFY-YAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGH 265

  Fly   190 AISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKAS 254
            .::::|.|:.:.|...|..|.||.||::..:..|||.:::|.:::.|:.|:::.:|:|.:....:
  Fly   266 VVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRT 330

  Fly   255 ASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSI----YAA 315
            ::...::|:..|.|::::||||.||||:||||||:.|.:::...|:.|:..||....|    :|.
  Fly   331 SAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFAR 395

  Fly   316 LQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARR 380
               ..::|::::|||||.||.:|.:.|.:..|::::||.:|..::..|.|.||...||.|.|.||
  Fly   396 ---RIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRR 457

  Fly   381 VVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQP 445
            |.:|:...|..:.:.  .:.|..:.....| |:.:.....::|   .:|.|.:.|.||      |
  Fly   458 VEQFMQSEELGSSDK--SEGPSKDTVPGNP-PSNNNEADLLKS---AISIRDLKAKWD------P 510

  Fly   446 RKPH--IEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQ 508
            ..|.  :.||:..|..|..|.::|..|||||:|:.|||||::...|:::|:|.:||.:|:.|:|.
  Fly   511 NSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFS 575

  Fly   509 GSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYR 573
            |::|:||||.:..:.:||..||..|.|:||.:|||..|.|:|||||.:|||||||||:|||:|||
  Fly   576 GTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYR 640

  Fly   574 QADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGS 638
            :|.|||.||||:||||.|.:.|.|:|....|.|...:||||..|.|..|||:::|..|::...|.
  Fly   641 KASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGD 705

  Fly   639 YEEL--KDVITHHAAL---------DLEAIEADKQQVKRVLSQVDRTSKQL----SKGEEKDPAT 688
            ||.|  ..:||...:|         :.|.:..:....|..::.:...|:|.    |.|:|     
  Fly   706 YESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKE----- 765

  Fly   689 IQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEED- 752
                  :.|:|..|.:|...|:.||:|.|......::||..|||:......|.|::.|...|.. 
  Fly   766 ------HVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTA 824

  Fly   753 RGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFF 817
            .|:..::|.| :::..|..||::::|::.:.|..:|..|.:..:.|:.||:.:::.:.||.|:||
  Fly   825 AGHGEMEDME-SKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFF 888

  Fly   818 NANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFC 882
            :.|..|.:||||:.|:..||..||..::|.:|..:.:..:::::|..|..||:|..::.::.|..
  Fly   889 SINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHL 953

  Fly   883 RALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVS 947
            |.||:..||.|||:|::.|||:|||...:.:|.:|||::||...||:.|..:|:.:|||.|:|:|
  Fly   954 RNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYIS 1018

  Fly   948 ANRAFSFWTDLICVIYILAVTFSFLVINQSFYSG---DVGLAITQSMTLVIMCQWGMRQTAEMEN 1009
            .::||.:..:.||||||..:|.||.    :|..|   ||||.|||:|.|:.|.|||:|||||:||
  Fly  1019 TSQAFGYCMNCICVIYISIITLSFF----AFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELEN 1079

  Fly  1010 NMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPG--DEDILRGLNFESQ 1072
            .||:||||:||.....|..||:|........||:.|.:.|::|.:||:|.  .|::|:.|:|..|
  Fly  1080 TMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQ 1144

  Fly  1073 PMEKIGIVGRTGAGKSSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTL 1137
            |.||:||||||||||||:|.|||||:..:|::.||..|..::||||||.:||||||:|||||||:
  Fly  1145 PREKVGIVGRTGAGKSSLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTM 1209

  Fly  1138 RFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNR 1202
            |:|||||||.|||.||..|::||||:.|:.|..||:.::.:||:|||:||||||||||||||:||
  Fly  1210 RYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENR 1274

  Fly  1203 VLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKL 1267
            :|||||||||||.:||.|||.||::||.:||||||||||||::|:|.|:|||||::||||:|::|
  Fly  1275 ILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYEL 1339

  Fly  1268 LQRKDGALL-KLVNQNDATTVKFLKRIASESY 1298
            :.:.|..:. .||||:...:.:.|.:||.|::
  Fly  1340 MTKSDSKVFHNLVNQSGRASYEGLLKIAQETF 1371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 520/1291 (40%)
ABC_membrane 95..360 CDD:294371 81/269 (30%)
ABCC_MRP_domain1 428..632 CDD:213217 99/205 (48%)
ABC_membrane 728..994 CDD:294371 96/269 (36%)
ABCC_MRP_domain2 1045..1264 CDD:213211 142/220 (65%)
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 520/1286 (40%)
ABC_membrane 171..437 CDD:294371 81/270 (30%)
ABCC_MRP_domain1 499..699 CDD:213217 99/205 (48%)
ABC_membrane 799..1045 CDD:294371 86/250 (34%)
ABCC_MRP_domain2 1115..1336 CDD:213211 142/220 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45440899
Domainoid 1 1.000 179 1.000 Domainoid score I1056
eggNOG 1 0.900 - - E2759_KOG0054
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 133 1.000 Inparanoid score I246
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - P PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
109.800

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