DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC1

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_016878726.1	Gene:	ABCC1 / 4363	HGNCID:	51	Length:	1549	Species:	Homo sapiens

Alignment Length:	1396	Identity:	475/1396 - (34%)
Similarity:	739/1396 - (52%)	Gaps:	207/1396 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE--------- 70
            |...|:.:|:..|.|:..:..:|.|:.|:.|.|:.......||.:...|..:|:||
Human   227 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 291

  Fly    71 --------------------------------SKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMA 103
                                            .|:.||||.::::|.:|..|     |.|....|
Human   292 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYF-----LMSFFFKA 351

  Fly   104 IHSFQ----PLLLGGLISYFAYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVR 164
            ||...    |.:|..||.:  ...|.......|.|.:.:.:.:.:.:||.|.:....|..|.|::
Human   352 IHDLMMFSGPQILKLLIKF--VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIK 414

  Fly   165 LACAGLVYRKCL------RASASSGEGLGGQAISVMSIDLSQF-DLTFYFFHDLWKGPVEACIFG 222
            .|..|.||||.|      |.|::.||     .:::||:|..:| ||..| .:.:|..|::..:..
Human   415 TAVIGAVYRKALVITNSARKSSTVGE-----IVNLMSVDAQRFMDLATY-INMIWSAPLQVILAL 473

  Fly   223 YLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAW 287
            ||:...:|.:.|.|:|.:|:::|:.|..|..:.::.....|.:|.|:||||||:..|:|:|:|||
Human   474 YLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAW 538

  Fly   288 EKSFGRLIAAVRQSEVKAIRGSMSIYA----ALQCTNMISKISLFLSLVAYVYV--GDLVTAKKV 346
            |.:|...:.|:||.|:|.::.|..:.|    ...||..:..:..|   ..||.:  .:::.|:..
Human   539 ELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF---AVYVTIDENNILDAQTA 600

  Fly   347 FILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPK 411
            |:..:.:.:|... |:..||.|::..|..||.:|:..||...|             ||.|:.:.:
Human   601 FVSLALFNILRFP-LNILPMVISSIVQASVSLKRLRIFLSHEE-------------LEPDSIERR 651

  Fly   412 PAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTL 476
            |.:.|      ..|..::.|..:.:|.:..     .|.:.||:|.|..|..|.:||.||.|||:|
Human   652 PVKDG------GGTNSITVRNATFTWARSD-----PPTLNGITFSIPEGALVAVVGQVGCGKSSL 705

  Fly   477 LHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLEL 541
            |.|:|.|::.::|.|.:.|.::|..||.|:...|:||||||..|.||..||:|:.||.|..|||:
Human   706 LSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI 770

  Fly   542 LPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLL 604
            ||.||.|.:||:|::||||||.|::||||||..||||||||||:||||.|||.:.:...  ..:|
Human   771 LPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGML 835

  Fly   605 DGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL-------KDVITHHAALDLEAIEADK- 661
            ..|.||||||.:..|..||.::::.|||:::.|||:||       .:.:..:|:.:.|. :|::
Human   836 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQ-DAEEN 899

  Fly   662 ------------QQVKRVLSQVDRTSKQLSKGEEKDPATIQD----ENGNAEQQLQGAVSYDTYK 710
                        :|::..:...|...|||.:......:...|    .|..||.|...|...:|:|
Human   900 GVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK 964

  Fly   711 A------------------YFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW-ATWEEDRGYD 756
            .                  |.:|:|   |....||:|:..  |..|..:..:.| :.|.:|...:
Human   965 LMEADKAQTGQVKLSVYWDYMKAIG---LFISFLSIFLFM--CNHVSALASNYWLSLWTDDPIVN 1024

  Fly   757 SVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRI-----SLTLHDQLYHGIIRAWMYF 816
            ...::  |:.::.::..:.:...:|:|      .:.|.:.|     |..||..|.|.|:|:.|.|
Human  1025 GTQEH--TKVRLSVYGALGISQGIAVF------GYSMAVSIGGILASRCLHVDLLHSILRSPMSF 1081

  Fly   817 FNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVI---- 877
            |...|||.::||||.::..||..:|:.:...:..|.:|:...:::.:|.     |.|.::|
Human  1082 FERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLAT-----PIAAIIIPPLG 1141

  Fly   878 -LLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQ-----N 936
             :.:|.:..|:.:||.|||:||::|||:|||.|:|..|.|.||:.:     ||....||     :
Human  1142 LIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFE-----EQERFIHQSDLKVD 1201

  Fly   937 TNSSALFLYVSANRAFSFWTDLI--CVIYILAVTFSFLVINQ-SFYSGDVGLAITQSMTLVIMCQ 998
            .|..|.:..:.|||..:...:.:  |::...|:   |.||:: |..:|.|||:::.|:.:.....
Human  1202 ENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL---FAVISRHSLSAGLVGLSVSYSLQVTTYLN 1263

  Fly   999 WGMRQTAEMENNMTSVERVLEYAQTPSEPPLE----SPKSVNLAAEWPQAGHLRFQDLRMRYSPG 1059
            |.:|.::|||.|:.:|||:.||::|..|.|.:    :|.|     .|||.|.:.|::..:||...
Human  1264 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS-----SWPQVGRVEFRNYCLRYRED 1323

  Fly  1060 DEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLALN-EGTIEIDGLDIGKLGLHDLRSRI 1123
            .:.:||.:|......||:||||||||||||:...|||:..: ||.|.|||::|.|:||||||.:|
Human  1324 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKI 1388

  Fly  1124 SIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQR 1188
            :|||||||||||:||.|||||.:.|||.:|::|:...||..|::|...|.....:||.|.|:|||
Human  1389 TIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQR 1453

  Fly  1189 QLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVM 1253
            ||||||||:||:.::||:|||||.||.|||.|||.||:|:|.:||||||||||:|:||...|:|:
Human  1454 QLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL 1518

  Fly  1254 DAGQIVEFGAPHKLLQR--------KDGALL 1276
            |.|:|.|:|||..|||:        ||..|:
Human  1519 DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	469/1378 (34%)
		ABC_membrane	95..360	CDD:294371	80/281 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	97/205 (47%)
		ABC_membrane	728..994	CDD:294371	78/284 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	123/219 (56%)
ABCC1	XP_016878726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S916
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.610