Protein Alignment CG10505 and Cftr

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 1457
• Identity: 530/1457 - (36%)
• Similarity: 797/1457 - (54%)
• Gaps: 215/1457 - (14%)

  Fly     1 MDASKQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQP 65
            ||:|  :.|.|: ||...|||||:.:|.|...:..:|.|..|:...|.:.|....||.|...|:.
  Fly     1 MDSS--AKPTRK-NPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLED 62

  Fly    66 HWEKE-----SKKKNPSLMRLIFKVY-GWQFVP--VCILYSLLEMAIHSFQPLLLGGLISYFA-- 120
            .|.||     .||:.|.|...:|:.: |...:.  :|.:|.:::..|    |.:|..|:..|.
  Fly    63 QWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLI----PAVLAQLLIQFQKT 123

  Fly   121 ----------------------------------------------------------------- 120
                                                                             
  Fly   124 PVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVE 188

  Fly   121 ---YGQTTV------TKESAY--LYAMGIVLCSLVTSLVFHPFMFYVF-----AVGTRVRLACAG 169
               :..|.|      |.|..:  :.::|.|   ||.|.:|..|:.:..     .:|.|:|:||..
  Fly   189 EVDHNATAVRSILDQTVEHMWNDMNSLGAV---LVLSTLFCCFLLHHVDLRQRLMGARMRIACCS 250

  Fly   170 LVYRKCLRAS-ASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTS 233
            |:|||.||.| .::|:...|..|:::|.|:::.|..|.|.|.:|..|::|.:..||:...:|..:
  Fly   251 LIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPA 315

  Fly   234 LIGIAFIVI-LIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAA 297
            ::|:..::: .:|:|...:|.::....|.|:..||||.:|||::..|||||||||||.|..::|.
  Fly   316 IVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAE 380

  Fly   298 VRQSEVKAIRGSMSIYAA------LQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLL 356
            .|:||:|.||     ||:      |.......:.:|:::|.|...:|..:||..||..:|||.:|
  Fly   381 ARRSEIKQIR-----YASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNIL 440

  Fly   357 NDSLLHYWPMAITTWAQTLVSARRVVEFLL---QVEKPTEESCCRDNPGLELDAEKPKPAQSGRL 418
            ......::|:|::..|:.|||.||:.:||:   :.|:....:..||..|
  Fly   441 QLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEG---------------- 489

  Fly   419 HCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGE 483
                .:::.::.:.::||||   |::|:|. ::.|:..|..||...::|.||:|||::|..:|||
  Fly   490 ----GDSRAVTIKDINASWD---IEKPQKT-LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGE 546

  Fly   484 IELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDAT 548
            :.::.|.|.:.|.:|||||:||:|.||:|.||||.|:::.|||:.|...|.|..|.:.||.||.|
  Fly   547 LPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKT 611

  Fly   549 VVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF---HRLLDGK-MR 609
            :|||||.||||||:|||:||||||:.|.|||.||||:||||.||:.|.|:..   .||...| .|
  Fly   612 LVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATR 676

  Fly   610 ILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL--------------------KDVITHHAALDL 654
            |||||.|..|...|.:::::.|::.:||:|:||                    ::.....:.|.:
  Fly   677 ILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSV 741

  Fly   655 EAIEADKQQ------VKRVLSQVDRTSKQLSKGEEKDPATIQ---DENGNAEQQLQGAVSYDTYK 710
            .::|:|.:.      ||....|:.:.|..:...:..|...:.   ||:..||.|..|.:|...:.
  Fly   742 NSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWY 806

  Fly   711 AYFRA----LGAPFLV-CLVLSMFVLARGCQAVMDIFISRWATWEEDR--GYDSVDDYEATRTKM 768
            .||.|    |...|:| .:|:|..|    |.: .|.|.:.|...|..|  |..:...:|.    |
  Fly   807 EYFHAGSTLLSFSFMVFVMVMSQVV----CSS-SDFFANIWTQQEHQRSQGEATFSTFEC----M 862

  Fly   769 VIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDI 833
            .| |..|::..:.:...|.|.||.:|:..|..|||:::..|:.|.|.||:..||||:|||||.|:
  Fly   863 YI-YGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDM 926

  Fly   834 QNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWL----LIPAAIMVILLYFCRALYIGASRSLK 894
            ..:|..||:||||.:|..:.:..:|:::.|.|..|    |:.|.:.|::|    .||:..|:.||
  Fly   927 GAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLIL----KLYLRPSQDLK 987

  Fly   895 RIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLI 959
            |:|.:.|||::||.:.:..|.:.|||......:.:.|...|:.:||...|.::.|.....|.|.:
  Fly   988 RLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV 1052

  Fly   960 CVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTP 1024
            ..|::.:|||||::.:::.|||:|||||.|:|.|..|.|:|:||.||....||||||||:|.:..
  Fly  1053 SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELE 1117

  Fly  1025 SEPPL--ESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGK 1087
            .||.|  ::|..     :||..|.:.|:::..||.|....:||.||...:...|:||||||||||
  Fly  1118 QEPALGEKTPPQ-----QWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGK 1177

  Fly  1088 SSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESL 1152
            ||:|.||||||..||.|.|||::.|.:.|..||:|||||||||||||.|:|:|||||:..:|..|
  Fly  1178 SSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAEL 1242

  Fly  1153 WSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTET 1217
            ||||:||:|:|.:.    ||...:.:.|.|||:|||||:||||||||.|:|||:||||||||.:|
  Fly  1243 WSALEDVELRKAIP----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQT 1303

  Fly  1218 DILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQN 1282
            |.|||.||:.||.:|||||:|||||||||:|.::|||||..|||..|:.||::..|.|.::|...
  Fly  1304 DALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEAT 1368

  Fly  1283 DATTVKFLKRIASESYMR----RNRRD 1305
            ...: :.||:.||:|:.|    |:.||
  Fly  1369 GGES-EALKKTASDSHKRMQRERDERD 1394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	512/1403 (36%)
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	512/1402 (37%)