DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Mrp4

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster

Alignment Length:	1338	Identity:	537/1338 - (40%)
Similarity:	807/1338 - (60%)	Gaps:	87/1338 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE-S 71
            :|:..|:|      :|..:|.:...|..|||::.|:...||..|....|:||...|...|::: :
  Fly    12 NPRERSSP------LSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVA 70

  Fly    72 KKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAM 136
            |.:.|.|.|.:.||:|:......:.....|......||:.|.|:::|||......:|  |.|:|.
  Fly    71 KNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSK--AQLWAA 133

  Fly   137 GIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAISVMSIDLSQ 200
            |::..|:.:..:.||:|..:..:|.::|:|.:.|:|||.||.|.:: |:...||.::::|.|:.:
  Fly   134 GLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGR 198

  Fly   201 FDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHR 265
            |||.....|.||..|:|.....|||..::|.:|:.|:|.:::.:|.|::..|.::....|:|...
  Fly   199 FDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRT 263

  Fly   266 DARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSE------VKAIRGSMSIYAALQCTNMISK 324
            |.||::|||||..|||||||||||.||:::...|.:|      |..|||.:..:|.     .:|:
  Fly   264 DERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAM-----FLSR 323

  Fly   325 ISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVE 389
            |....||:|:|.:|:::.|:|.|.:::||.:|..|:..::|..|:.:|:.|||.||:..|:.:.|
  Fly   324 IFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPE 388

  Fly   390 KPTEESCCRDNPGLELDAEKP---KPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIE 451
            ....:.....|...:  ||.|   .|..:|      .....:.|.:..|.|:..|:    :|.:|
  Fly   389 TKVRDKSKVKNANQK--AESPNGDSPKGNG------IPENLIEFSQFQARWESHSL----EPTLE 441

  Fly   452 GISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENIL 516
            .|:..:...:.|.::|.||:|||:|:.|||||:....|.:.::|..|||||:||:|.|::|:|||
  Fly   442 DINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNIL 506

  Fly   517 FVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFD 581
            |...:::.|||.||..|.|:||.||||.||.|:|||||.||||||||||:|||||||:|||||.|
  Fly   507 FGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLD 571

  Fly   582 DPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELK--- 643
            |||:|||..||:.|.|:|....|..::.|||||.:|.|:..|.:::::.|:::..|:|..:|
  Fly   572 DPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSG 636

  Fly   644 ----DVIT--HHAALDLEAIE---ADKQQVKRVLSQVDRTSK------------QLSKGEEK--D 685
                .::|  :..|.||:.|:   .|...:..|.|...|.||            .||...|.  .
  Fly   637 LDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQ 701

  Fly   686 PATIQDENGNAEQQLQGAVSYDTYKAYFRALGAP-----FLVCLVLSMFVLARGCQAVMDIFISR 745
            .|::|.:    |.:::|.:....||.|..: |:.     |:|.|.|:..:|   |.|. |.|:|.
  Fly   702 EASLQMQ----ETRVEGKIGLGLYKEYLTS-GSSWFMIFFMVFLCLATQIL---CSAA-DYFLSY 757

  Fly   746 WATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALF-LLRTFGFFFMCLRISLTLHDQLYHGI 809
            |.    |:..|...|.......|  :|...|.:.:.:| ::||..|:.|.:|.|..||:.:|.||
  Fly   758 WV----DKNVDGQTDINTDPQDM--YYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGI 816

  Fly   810 IRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAI 874
            .||.|||||.|||||:|||||.|:..:|..||..|:|.:|..:.::.::|::.|.|.:.||....
  Fly   817 TRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLA 881

  Fly   875 MVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNS 939
            :.|:.|:.|..|:..||.:||:|::.|||||||.:.|..|..|||::.|..:|...|...|:.:|
  Fly   882 LAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHS 946

  Fly   940 SALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQT 1004
            |..:.:::.||||.::.|..|.:||:.:..::. ||.....|:|||||||:|.:..|.||.|||:
  Fly   947 SGYYTFLATNRAFGYYLDCFCTLYIVIIILNYF-INPPQSPGEVGLAITQAMGMTGMVQWAMRQS 1010

  Fly  1005 AEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDED--ILRGL 1067
            ||:||.||:||||:||.:...|...:|.:....:..||:.|.:..:||.:||.|..:.  :|:.|
  Fly  1011 AELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKAL 1075

  Fly  1068 NFESQPMEKIGIVGRTGAGKSSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVL 1132
            ||..:|.||:||||||||||||:|.|||||:.|||.|.||..|...:||.||||:||||||:|||
  Fly  1076 NFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVL 1140

  Fly  1133 FSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAI 1197
            |||::|:|||||:|.:|..||.||::||||..::.|..||..::.:||||||:||||||||||||
  Fly  1141 FSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAI 1205

  Fly  1198 LRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFG 1262
            ||:||||||||||||||.:||.|||.||::||.:||||||||||:|:||:|.|||||||.:||||
  Fly  1206 LRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFG 1270

  Fly  1263 APHKLLQRKDGALLK-LVNQNDATTVKFLKRIASESYM 1299
            :|::||...:..:.. :|.:....|...|.::|.::::
  Fly  1271 SPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHL 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	530/1300 (41%)
		ABC_membrane	95..360	CDD:294371	93/271 (34%)
		ABCC_MRP_domain1	428..632	CDD:213217	100/203 (49%)
		ABC_membrane	728..994	CDD:294371	100/266 (38%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	143/220 (65%)
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	532/1305 (41%)
		ABC_membrane	93..359	CDD:294371	93/272 (34%)
		ABCC_MRP_domain1	422..622	CDD:213217	100/203 (49%)
		ABC_membrane	735..978	CDD:294371	93/252 (37%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	143/220 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440896
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.800