Protein Alignment CG10505 and abcc2

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_956883.2
• Gene: abcc2 / 393561
• ZFINID: ZDB-GENE-040426-1523
• Length: 1567
• Species: Danio rerio
• Alignment Length: 1429
• Identity: 469/1429 - (32%)
• Similarity: 741/1429 - (51%)
• Gaps: 241/1429 - (16%)

  Fly     2 DASKQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREEL------DASK---------LYEHL 51
            |.|.::....|:||..||..:|:..|.|.:|:..||.:..|      |.:|         .:|.:
Zfish   195 DVSPEAKKVAETNPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDV 259

  Fly    52 PSFDSESLTRNLQ------------------------------PHWEKESKKKNPS--------- 77
            .:.:.:....|||                              ...|||||||...
Zfish   260 MAKELKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDY 324

  Fly    78 ----LMRLIFKVYGWQFVPVCI---LYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKES----A 131
                |:..|.|    .|..|.:   |:.||:..:....|.||..:|::      |..|:|    .
Zfish   325 PQSWLVTTIVK----SFKGVLLESALFKLLQDLLSFASPQLLKLMIAF------TQNKDSYAWTG 379

  Fly   132 YLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAISVMS 195
            ||||:.:||.:.|.|:|...:....|.:|.:||.|....||:|.|..|..| .|...|:.:::||
Zfish   380 YLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMS 444

  Fly   196 IDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTR 260
            .|..:|:....|.|.||..|::..:....:..::|.:.|.|:..:|:::|:..|.|..|..|..:
Zfish   445 ADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQ 509

  Fly   261 SAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIR-----GSMSIYAALQCTN 320
            :.|.:|:|:|::|:::..|:::|.||||.||...:..:|:.|:|.:|     .|:|.: ...|..
Zfish   510 NMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTF-IFSCAP 573

  Fly   321 MISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFL 385
            .:..::.|...|: |...:::.|:|.|...|.:.:|...|. ..|..|:...||.||.:|:.:||
Zfish   574 ALVSLATFAVFVS-VSPDNILDAEKAFTSISLFNILRFPLA-MLPQLISIMVQTSVSKKRLEKFL 636

  Fly   386 ----LQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPR 446
                |.....|.:|                           |.|..:|....:.:|::.:
Zfish   637 SGDDLDTTTVTHDS---------------------------SITAAVSMTNGTYAWERDT----- 669

  Fly   447 KPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSI 511
            :|.::.:|..|..|:.|.:||.|||||::|:.|:|||:..::|.:.::|.::|..||.|:...::
Zfish   670 EPVLKRVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATL 734

  Fly   512 RENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQAD 576
            ::||||....:|:||::|:.||.|..||:|||..|.|.:||:||:||||||.|::||||||..||
Zfish   735 KDNILFGSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSAD 799

  Fly   577 IYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSY 639
            :||.||||:|||:.|||.|.:|..  :.||..|.|||:||.:..|..||::::|..|.:::.|||
Zfish   800 VYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSY 864

  Fly   640 EELK-----------------------------------DVITHHAALDLEAIEADKQQVKRVLS 669
            |.|:                                   ::.|....|:.:|..:.:..|...|.
Zfish   865 ESLRASKGAFSEFLETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLK 929

  Fly   670 QVD--RTSKQLSKGE-------------EKDPATIQDENG----NAEQQLQGAVSYDTYKAYFRA 715
            :.:  |.|::.||..             :|||   :|:.|    ..|....|.|.:..|..|..|
Zfish   930 RENSLRHSQRHSKRNGSVKVRKNSSLRAQKDP---EDKKGQRLIEKEMMETGRVKFSVYLQYLSA 991

  Fly   716 L-----GAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEAT------RTKMV 769
            :     |..|:...:.::.|:.:      ::::|.|..       ||::.:..|      .|::.
Zfish   992 MGWWYVGFSFVFYFIQNVAVIGQ------NLWLSDWTD-------DSIEYFNQTYPNHIRDTRIG 1043

  Fly   770 IWYTVLLLLTLALFLLRTFGFFFMC---LRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSS 831
            ::..    |.||...|..||...:.   :..|.|||..|...|::..|.||:..||||::|||:.
Zfish  1044 VFGA----LGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAK 1104

  Fly   832 DIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRI 896
            ||..||..:|.:....:..|:.|:..|.::.:|..........|.::.||.:..|:..||.|:|:
Zfish  1105 DIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRL 1169

  Fly   897 ESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQ-----------NTNSSALFLYVSANR 950
            :|::|||||||..:|..|.|.||:           :|||           :.|..:::.::.:||
Zfish  1170 DSVSRSPIYSHFGETVSGLSVIRA-----------YGHQDRFLKRNEHTIDQNLKSVYPWIVSNR 1223

  Fly   951 AFSFWTDLI--CVIYILAVTFSFLVINQ-SFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMT 1012
            ..:...:.:  .|::..|:   |.||:: |..||.|||:|:.::.:.....|.:|.|:|:|.|:.
Zfish  1224 WLAMRLESLGNLVVFFAAL---FAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIV 1285

  Fly  1013 SVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKI 1077
            :||||.|||:..:|.|..:  ||....:||.||::||:|.::||.|..|.:|.|:..:.|..|||
Zfish  1286 AVERVREYAEIQNEAPWVT--SVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKI 1348

  Fly  1078 GIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNL 1141
            ||||||||||||:...|||:. ..:|.|.||.:||..|||||||||::||||||||||||||.||
Zfish  1349 GIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNL 1413

  Fly  1142 DPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVM 1206
            |||...||..:||.|:...||::|..|..||...:.:||.|.|:|||||:|||||:||::|:|::
Zfish  1414 DPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILIL 1478

  Fly  1207 DEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQR 1270
            |||||.||.|||.|||.||:.:|:.||||||||||:|::|:..|:|:|:|:||||.:|::||.:
Zfish  1479 DEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLSK 1542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	465/1416 (33%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	469/1429 (33%)