DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc2

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1429	Identity:	469/1429 - (32%)
Similarity:	741/1429 - (51%)	Gaps:	241/1429 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DASKQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREEL------DASK---------LYEHL 51
            |.|.::....|:||..||..:|:..|.|.:|:..||.:..|      |.:|         .:|.:
Zfish   195 DVSPEAKKVAETNPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDV 259

  Fly    52 PSFDSESLTRNLQ------------------------------PHWEKESKKKNPS--------- 77
            .:.:.:....|||                              ...|||||||...
Zfish   260 MAKELKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDY 324

  Fly    78 ----LMRLIFKVYGWQFVPVCI---LYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKES----A 131
                |:..|.|    .|..|.:   |:.||:..:....|.||..:|::      |..|:|    .
Zfish   325 PQSWLVTTIVK----SFKGVLLESALFKLLQDLLSFASPQLLKLMIAF------TQNKDSYAWTG 379

  Fly   132 YLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAISVMS 195
            ||||:.:||.:.|.|:|...:....|.:|.:||.|....||:|.|..|..| .|...|:.:::||
Zfish   380 YLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMS 444

  Fly   196 IDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTR 260
            .|..:|:....|.|.||..|::..:....:..::|.:.|.|:..:|:::|:..|.|..|..|..:
Zfish   445 ADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQ 509

  Fly   261 SAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIR-----GSMSIYAALQCTN 320
            :.|.:|:|:|::|:::..|:::|.||||.||...:..:|:.|:|.:|     .|:|.: ...|..
Zfish   510 NMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTF-IFSCAP 573

  Fly   321 MISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFL 385
            .:..::.|...|: |...:::.|:|.|...|.:.:|...|. ..|..|:...||.||.:|:.:||
Zfish   574 ALVSLATFAVFVS-VSPDNILDAEKAFTSISLFNILRFPLA-MLPQLISIMVQTSVSKKRLEKFL 636

  Fly   386 ----LQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPR 446
                |.....|.:|                           |.|..:|....:.:|::.:
Zfish   637 SGDDLDTTTVTHDS---------------------------SITAAVSMTNGTYAWERDT----- 669

  Fly   447 KPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSI 511
            :|.::.:|..|..|:.|.:||.|||||::|:.|:|||:..::|.:.::|.::|..||.|:...::
Zfish   670 EPVLKRVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATL 734

  Fly   512 RENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQAD 576
            ::||||....:|:||::|:.||.|..||:|||..|.|.:||:||:||||||.|::||||||..||
Zfish   735 KDNILFGSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSAD 799

  Fly   577 IYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSY 639
            :||.||||:|||:.|||.|.:|..  :.||..|.|||:||.:..|..||::::|..|.:::.|||
Zfish   800 VYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSY 864

  Fly   640 EELK-----------------------------------DVITHHAALDLEAIEADKQQVKRVLS 669
            |.|:                                   ::.|....|:.:|..:.:..|...|.
Zfish   865 ESLRASKGAFSEFLETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLK 929

  Fly   670 QVD--RTSKQLSKGE-------------EKDPATIQDENG----NAEQQLQGAVSYDTYKAYFRA 715
            :.:  |.|::.||..             :|||   :|:.|    ..|....|.|.:..|..|..|
Zfish   930 RENSLRHSQRHSKRNGSVKVRKNSSLRAQKDP---EDKKGQRLIEKEMMETGRVKFSVYLQYLSA 991

  Fly   716 L-----GAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEAT------RTKMV 769
            :     |..|:...:.::.|:.:      ::::|.|..       ||::.:..|      .|::.
Zfish   992 MGWWYVGFSFVFYFIQNVAVIGQ------NLWLSDWTD-------DSIEYFNQTYPNHIRDTRIG 1043

  Fly   770 IWYTVLLLLTLALFLLRTFGFFFMC---LRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSS 831
            ::..    |.||...|..||...:.   :..|.|||..|...|::..|.||:..||||::|||:.
Zfish  1044 VFGA----LGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAK 1104

  Fly   832 DIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRI 896
            ||..||..:|.:....:..|:.|:..|.::.:|..........|.::.||.:..|:..||.|:|:
Zfish  1105 DIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRL 1169

  Fly   897 ESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQ-----------NTNSSALFLYVSANR 950
            :|::|||||||..:|..|.|.||:           :|||           :.|..:::.::.:||
Zfish  1170 DSVSRSPIYSHFGETVSGLSVIRA-----------YGHQDRFLKRNEHTIDQNLKSVYPWIVSNR 1223

  Fly   951 AFSFWTDLI--CVIYILAVTFSFLVINQ-SFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMT 1012
            ..:...:.:  .|::..|:   |.||:: |..||.|||:|:.::.:.....|.:|.|:|:|.|:.
Zfish  1224 WLAMRLESLGNLVVFFAAL---FAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIV 1285

  Fly  1013 SVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKI 1077
            :||||.|||:..:|.|..:  ||....:||.||::||:|.::||.|..|.:|.|:..:.|..|||
Zfish  1286 AVERVREYAEIQNEAPWVT--SVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKI 1348

  Fly  1078 GIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNL 1141
            ||||||||||||:...|||:. ..:|.|.||.:||..|||||||||::||||||||||||||.||
Zfish  1349 GIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNL 1413

  Fly  1142 DPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVM 1206
            |||...||..:||.|:...||::|..|..||...:.:||.|.|:|||||:|||||:||::|:|::
Zfish  1414 DPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILIL 1478

  Fly  1207 DEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQR 1270
            |||||.||.|||.|||.||:.:|:.||||||||||:|::|:..|:|:|:|:||||.:|::||.:
Zfish  1479 DEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLSK 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	465/1415 (33%)
		ABC_membrane	95..360	CDD:294371	78/277 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	88/205 (43%)
		ABC_membrane	728..994	CDD:294371	77/288 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	128/219 (58%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	469/1429 (33%)
		ABC_membrane	346..612	CDD:294371	78/273 (29%)
		ABCC_MRP_domain1	656..856	CDD:213217	88/204 (43%)
		ABC_membrane	1001..1270	CDD:279056	78/299 (26%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	128/219 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660