Protein Alignment CG10505 and abcc4

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001007039.2
• Gene: abcc4 / 368620
• ZFINID: ZDB-GENE-030616-511
• Length: 1331
• Species: Danio rerio
• Alignment Length: 1333
• Identity: 518/1333 - (38%)
• Similarity: 799/1333 - (59%)
• Gaps: 79/1333 - (5%)

  Fly    12 ESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKK--- 73
            :|||...||:.|:..|.|::.:|..|.:..|:...::..||...|:.|...||.:|::|.:|
Zfish    13 KSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYWDQEKEKAAK 77

  Fly    74 --KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFA-YGQTTVTKES-AYLY 134
              |.|.|.:.|.:.| |:...|..:::|:|.:|...||:.||.||.||. |....:...| ||.|
Zfish    78 ELKTPKLTKAIIRCY-WKSYAVLGVFTLIEESIKVIQPVFLGKLIKYFENYRHDDMAALSEAYGY 141

  Fly   135 AMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAISVMSIDL 198
            |.|:.|.:|..:|:.|.:.::|...|.::|:|...::|||.|..||:: |:...||.::::|.|:
Zfish   142 ATGVCLSTLGLALLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQTTTGQIVNLLSNDV 206

  Fly   199 SQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAK 263
            ::||....|.|.||.||::|.....|:.:::|.:.|.|:|.:|.|:|||....|..:.:.:::|.
Zfish   207 NKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMFGKLFSKYRSKTAA 271

  Fly   264 HRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMIS----- 323
            ..|:|::.|||::..|::||||||||.|..|:..||:.|:..|..|    :.|:..||.|
Zfish   272 LTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSS----SYLRGLNMASFFTAN 332

  Fly   324 KISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQV 388
            ||.||::...||.||:.::|.:||:..|.|..:..::..::|.||...:::.:|.||:.:|||.
Zfish   333 KIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAISIRRIKKFLLL- 396

  Fly   389 EKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGI 453
                 :...:::..|..:.:|....:...|.|.               |||..    ..|.::.:
Zfish   397 -----DELVKNHLPLSQEEKKEPSVEMQDLICY---------------WDKTL----DAPTLQNV 437

  Fly   454 SFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFV 518
            .|.:..||.:.::|.||:|||:||..:|||:...:|.::|.|.::||:||||||.|:||.||||.
Zfish   438 CFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPGTIRSNILFG 502

  Fly   519 EQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDP 583
            ::.:.:||..|:.||.|.||:||||.||.||:|:||.:||||||||:.||||||:.|||||.|||
Zfish   503 KELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDP 567

  Fly   584 LAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITH 648
            |:||||:|.:.|.::|...:|..|.||||||.:|.||:.:|:|:|:.|.:..:|||.||:
Zfish   568 LSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSYSELQ----- 627

  Fly   649 HAALDLEAI--------------EADKQQVKRVLSQ---VDRTSKQLSKGEEKDPATIQDENGNA 696
            .:.||..::              ||.:....|.:||   ...:|..||..::.|....:..:..|
Zfish   628 QSGLDFTSLLKKDEEEESGSEKGEAPRSPRSRTVSQNSVRSHSSSVLSVKDDSDQLPAEPVHTMA 692

  Fly   697 EQ-QLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYD---- 756
            |: :.:|.:....|..||||.....::.|:|.:.:||:....:.|.::|.|||.:|...::
Zfish   693 EELRSEGNIGIRMYWKYFRAGANVVMLVLLLLLNLLAQTFYILQDWWLSYWATEQEKLDHNTNNT 757

  Fly   757 SVDDYEATRTKMVI-------WYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWM 814
            :.::..|..|...:       .|..|...|:....:|....|...:..:..||:::::.|:|..:
Zfish   758 NTNNTSAGNTTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNALVSSAEMLHNRMFNSILRTPV 822

  Fly   815 YFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILL 879
            .||:.||.||:|||||.||.::|..||...:|.:|..:.:|.|:.:.:....|:|||...::|..
Zfish   823 RFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIAVASSVIPWILIPVLPLLICF 887

  Fly   880 YFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFL 944
            .|.|..::..||.:|||||.||||::||.:.:..|..|||:..|..:.:|||..||:.:|.|.||
Zfish   888 LFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAHQDLHSEAWFL 952

  Fly   945 YVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMEN 1009
            :::.:|.|:...|.:|.:::....|..|::..:..:||||||::.::||:.|.|||:||:||:||
Zfish   953 FLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALSYAVTLMGMFQWGVRQSAEVEN 1017

  Fly  1010 NMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPM 1074
            .|||||||:||.:..||.|.|:.|  ..:.:||..|.:.|..:...||.....:|:.::...:|.
Zfish  1018 MMTSVERVVEYTELESEAPWETQK--RPSPDWPNRGLITFDRVNFSYSSDGPVVLKNISAMFRPR 1080

  Fly  1075 EKIGIVGRTGAGKSSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRF 1139
            ||:||||||||||||:|.|||||:..||.|.:||:...::||||||.::||||||||||:||:|.
Zfish  1081 EKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGLHDLRQKMSIIPQDPVLFTGTMRK 1145

  Fly  1140 NLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVL 1204
            |||||::.||..||.||::|:||..|..|.|.|...:.:.|||||:||||||||||||||:||||
Zfish  1146 NLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGSNFSVGQRQLVCLARAILRKNRVL 1210

  Fly  1205 VMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            ::||||||||..||.|||:||:.||.|||||||||||:|::|:|.:||:|||:|.|:.|||.|||
Zfish  1211 IIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGRIHEYDAPHVLLQ 1275

  Fly  1270 RKDGALLKLVNQNDATTVKFLKRIASESYMRRN 1302
            .:.|...|:|.|........|.:.|.::|..|:
Zfish  1276 NQSGIFYKMVQQTGKAEATSLLQTAKQAYANRS 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	507/1297 (39%)
		ABC_membrane	95..360	CDD:294371	96/272 (35%)
		ABCC_MRP_domain1	428..632	CDD:213217	99/203 (49%)
		ABC_membrane	728..994	CDD:294371	86/276 (31%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	129/218 (59%)
abcc4	NP_001007039.2	SunT	11..1289	CDD:331423	514/1312 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760