DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and MRP

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1400	Identity:	475/1400 - (33%)
Similarity:	736/1400 - (52%)	Gaps:	180/1400 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQSSPKRESN--PFIKANIISKWLFLWMHSVFRKGRREELDASKLY---------EHLPSFD--- 55
            :|:..:|..|  |.:.|:.:|:..:.|...:..||.|..|:...|:         |.:|.|.
  Fly   213 RQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHW 277

  Fly    56 SESLTRNLQ--------------------PHWEKESKKKN-PSLMRLIFKVYGWQFVPVCILYSL 99
            ::::.:|.:                    ||.||..:||. .|:|..|:|.:|..|: ...|..|
  Fly   278 NQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFL-FGALMKL 341

  Fly   100 LEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVR 164
            ....:...||.:|..:|| |...|....:....|||:.:.:.:...:.:...:...:|.||.|:|
  Fly   342 FTDTLTFAQPQVLSLIIS-FVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIR 405

  Fly   165 LACAGLVYRKCLRASASS-GEGLGGQAISVMSIDLSQF-DLTFYFFHDLWKGPVEACIFGYLMTR 227
            .|....:|||.||.|.|: .|...|:.:::|::|..:| :||.| .:.:|..|::..:..|.:.:
  Fly   406 TALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTY-LNMIWSAPLQIGLALYFLWQ 469

  Fly   228 QVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFG 292
            |:|.:.|.|:|.::||||:....|....::..|..|::|.|||||||::..|:|:|:||||.||.
  Fly   470 QLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFE 534

  Fly   293 RLIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFL-SLVAY-VYV----GDLVTAKKVFILSS 351
            :.:..:|..|:..:|.:..:.|.   |:.:...:.|| |||.: .||    .:.::.:||.:..:
  Fly   535 KQVLDIRDKEIATLRSTAYLNAG---TSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIA 596

  Fly   352 YYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLEL-DAEKPKPAQS 415
            .:.|:...|. ..||.....|:|.||..|:.:||...|.         :|...| |:.||.|
  Fly   597 LFDLMKLPLT-ILPMLSVDIAETQVSVNRINKFLNSEEL---------DPNSVLHDSSKPHP--- 648

  Fly   416 GRLHCVQSETKCLSFRKVSASW-DKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHA 479
                        :|......|| |:.:::        .|:..:..|..|.:||.||||||:::.|
  Fly   649 ------------MSIENGEFSWGDEITLR--------NINIEVKKGSLVALVGTVGSGKSSVVQA 693

  Fly   480 ILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPR 544
            .|||:|.:.|.|...|:::|..||.|:...::|:||||.:.|:.|||..|:.||.|..|:::|..
  Fly   694 FLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSA 758

  Fly   545 GDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGK 607
            ||.|.:||:||:||||||.||:||||||..||:||.||||:||||.|||.:.::..  ..:|..|
  Fly   759 GDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARK 823

  Fly   608 MRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL-------KDVITHHAALDLEAIEADKQQVK 665
            .|:||||.|..|..||.:.:::.|::::.|::::|       .|.|..|.....|. |.:..|:|
  Fly   824 SRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEE-EEELNQIK 887

  Fly   666 RVLSQV------------------------------------------DRTSKQLSKGEEKDPAT 688
            |.:|..                                          .||.:|.|.......|:
  Fly   888 RQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAAS 952

  Fly   689 I---QDENG---NAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWA 747
            :   |:..|   ..|:...|.|.:..||.|.:::|. ||....|.:..:.:..|...::::::||
  Fly   953 LKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGI-FLSVATLVLNFVFQAFQIGSNLWLTQWA 1016

  Fly   748 TWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGF------FFMCLRISL------- 799
            .          |...|..|.:...|         |.:...|||      :|..:.:.|
  Fly  1017 N----------DQNVANDTGLRDMY---------LGVYGAFGFGQGVLAYFAVVIVYLGGFQAAK 1062

  Fly   800 TLHDQLYHGIIRAWM-YFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAI 863
            |:|::|...|||..: .||:..|.||:||.||.|:..||..||..|...:.|:..|:|.:|::::
  Fly  1063 TIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISL 1127

  Fly   864 ANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLE 928
            :....|.....:..|.||.:..|:..||.|.|:||::|||||||.::|..|.||||:.:...:..
  Fly  1128 STPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFI 1192

  Fly   929 QTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTL 993
            :......:.|....:..|.|||..:...:::..:.||..:. |.|:......|.|||:::.::.:
  Fly  1193 EESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASL-FAVLGGQTNPGLVGLSVSYALQV 1256

  Fly   994 VIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSP 1058
            .....|.:|.::::|.|:.||||:.||.:|..|.|.|..:..|....|||.|.:.||:.::||..
  Fly  1257 TQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYRE 1321

  Fly  1059 GDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTIEIDGLDIGKLGLHDLRSR 1122
            |.:.:|||::|..|..||:||||||||||||:..|||| :....|.|.|||:||..:|||.||||
  Fly  1322 GLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSR 1386

  Fly  1123 ISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQ 1187
            ::|||||||||||:||.|||||:.|:|:.:|.||:...||..|.||..||:..:.:||.|.|:||
  Fly  1387 LTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQ 1451

  Fly  1188 RQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLV 1252
            |||||||||:||:.:|||:|||||.||.|||.|||:||:|:|.|||||||||||:|::|:|.|:|
  Fly  1452 RQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIV 1516

  Fly  1253 MDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTV 1287
            :|.|||:||.:|.:||.....|...:.  .||..|
  Fly  1517 LDKGQIIEFASPTELLDNPKSAFYSMA--KDANLV 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	467/1372 (34%)
		ABC_membrane	95..360	CDD:294371	80/272 (29%)
		ABCC_MRP_domain1	428..632	CDD:213217	89/206 (43%)
		ABC_membrane	728..994	CDD:294371	75/279 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	132/219 (60%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	474/1397 (34%)
		ABC_membrane	338..601	CDD:279056	79/267 (30%)
		ABCC_MRP_domain1	649..848	CDD:213217	89/206 (43%)
		ABC_membrane	988..1260	CDD:279056	78/292 (27%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	132/219 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440907
Domainoid	1	1.000	173	1.000	Domainoid score	I751
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800