DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and CG7806

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster

Alignment Length:	1353	Identity:	407/1353 - (30%)
Similarity:	666/1353 - (49%)	Gaps:	162/1353 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKK------KNP 76
            :||:.|::||.|:..:..||...:|...:....||  |:.::||        .|:|      ::.
  Fly   229 EANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLP--DALNITR--------LSEKLHLALSQSQ 283

  Fly    77 SLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQ-PLLLGGLISYFAYGQTTVTKESAYLYAMGIVL 140
            ||.|.:.:.:|.:|..:.||..:.:::  .|. |||||||:.     |........|.||:|:..
  Fly   284 SLWRALHRCFGVEFYLIGILRLIADLS--GFAGPLLLGGLLR-----QDHADPNQVYYYALGLFG 341

  Fly   141 CSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGL---GGQAISVMSIDLSQFD 202
            .:|::::....|.:.:..|..::|:.....:|||.|.|     .||   ....:::||.|..:..
  Fly   342 STLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALEA-----RGLKESKPDLLNLMSTDTDRIV 401

  Fly   203 LTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDA 267
            .:...||..|..|.:.....||:..|:|...|.|:.|..:|||:..|.||....|.:.....:||
  Fly   402 NSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDA 466

  Fly   268 RVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFLSLV 332
            |:....|.:...:.||:.|||..|...|..:||.|::.:  |...|....|....:...:.:.|:
  Fly   467 RLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFL--SKRKYLDAMCVYFWATTPVLMCLL 529

  Fly   333 AY---VYVGDLVTAKKVFI-LSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTE 393
            .:   |.:|:.:.|...:. ::..|.|:..  |:.:|..:....:..||.:||.:.:   :.|..
  Fly   530 TFGVSVLMGNPLIASTTYTSVALLYMLIGP--LNAFPWVLNGLIEAWVSIKRVQQLM---DVPNL 589

  Fly   394 ESCCRDNPGLE------------LDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPR 446
            :.....||.:.            |||.|....|          .||.||     ..|......|.
  Fly   590 DYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQ----------MKCASF-----CHDSDEQTSPT 639

  Fly   447 KPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRV---EVHGRISYAAQQPWVFQ 508
            ...::.|:..|.|||.|.|.|.||.|||:.|.||:..::...|.|   |:.....|..|.||:.:
  Fly   640 PFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQR 704

  Fly   509 GSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYR 573
            |:||:||::..|::|:.|:.|:|||.|:.||::| .||...|||.|.:|||||:||:|||||||:
  Fly   705 GTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQ 768

  Fly   574 QADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGS 638
            ...:||.||.|:::||.|.:.::..|..|||..|.||:||.::||....:|:|.::.|:|..
  Fly   769 DKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP--- 830

  Fly   639 YEELKDVITHHAALDLEAIEADKQQVKRVLSQVDRTSKQLSKGEEK---DPATIQDENGNAEQQL 700
                .:.:|....|.|:....|:|:     ..|.|.|.:||...:|   |...::      |.:.
  Fly   831 ----SEYMTQSIELSLDEDADDEQE-----PTVRRRSVELSNQYDKKSLDSLLLE------ELRE 880

  Fly   701 QGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWAT------WEEDRGYDSV- 758
            .|.:|.:.:..|::|:.:|....::||: ||.:..:.:.|.:::.|.|      .:.|...|.:
  Fly   881 YGHLSGNVFTCYWKAVTSPLAFTVLLSV-VLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHIL 944

  Fly   759 ---------DDYEATRTKMVIWYTVLL---LLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIR 811
                     :....|:..:.|:..:.:   |:|||    |.|.|.:..::.::.:|::|...::.
  Fly   945 MRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLA----RAFLFAYAGIKAAIFMHEKLLKKVMF 1005

  Fly   812 AWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMV 876
            |...||:....||:|||||||...||.:||..:...|..|..:|..|.:...|..||.:....||
  Fly  1006 AKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMV 1070

  Fly   877 ILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSA 941
            .:....:..|..|||.:||:.|...||:|:|..:|..|.:|||||.|.|:.::.|......:..|
  Fly  1071 PIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKA 1135

  Fly   942 LFLYVSANRAFSFWTDLICVIYI------LAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWG 1000
            .....:|.:..:....|:..:.:      .|:|.|     .:...|.|||.|  |..|.|..|.|
  Fly  1136 QLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITAS-----HTTNPGLVGLCI--SYALSITGQLG 1193

  Fly  1001 --MRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAE----WPQAGHLRFQDLRMRYSPG 1059
              :...||.|..:.:|||:.:|.|      ||..::.:.:||    ||..|.|.|:::::.|...
  Fly  1194 DLLHAVAETEQELVAVERIDQYLQ------LEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREH 1252

  Fly  1060 DEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRI 1123
            ....|||:.|:::..|:|||||||||||:|::.||.|:| |..|.|.:|.:::..|.|..||.||
  Fly  1253 LAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERI 1317

  Fly  1124 SIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQR 1188
            .:|.|:|.||.||:|.||||.....|..:|.|:.:......:....|||..:::..|:|.|.|||
  Fly  1318 GVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQR 1382

  Fly  1189 QLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVM 1253
            ||:|||||:|:..:|:.:||.|:|:|.|:|:.||:.::..|..||:|.|||||..:...|.::|:
  Fly  1383 QLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVL 1447

  Fly  1254 DAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFLKRIASE----SYMRRN 1302
            |.|:|.|.|.|..|             .:|::|:.:...:|.:    .::|.|
  Fly  1448 DDGRICEEGNPQSL-------------ASDSSTIFYGMLLAQDIDPGEFIRSN 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	401/1313 (31%)
		ABC_membrane	95..360	CDD:294371	70/272 (26%)
		ABCC_MRP_domain1	428..632	CDD:213217	84/206 (41%)
		ABC_membrane	728..994	CDD:294371	76/290 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	93/219 (42%)
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	404/1336 (30%)
		ABC_membrane	328..560	CDD:294371	59/240 (25%)
		ABCC_MRP_domain1	621..827	CDD:213217	87/221 (39%)
		ABC_membrane	948..1192	CDD:279056	71/254 (28%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	93/219 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.870