DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCB5

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	1375	Identity:	310/1375 - (22%)
Similarity:	545/1375 - (39%)	Gaps:	363/1375 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 ILYSLLEMAIHSFQPLLLGGLISYFAYG---QTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYV 156
            ||.||:..|.....||:||.:......|   ||..|.
Human    52 ILASLVNGACLPLMPLVLGEMSDNLISGCLVQTNTTN---------------------------- 88

  Fly   157 FAVGTRVRLACAGLVYRKCLRASASSGE----------GLGGQAISVMSIDLSQFDLTF------ 205
                           |:.|.::.....|          |:|..|:....|.:|.:.:|.
Human    89 ---------------YQNCTQSQEKLNEDMTLLTLYYVGIGVAALIFGYIQISLWIITAARQTKR 138

  Fly   206 ---YFFHDLWK---GPVEACIFGYLMTRQ----------VG----------WTSLIGIAFIVI-- 242
               .|||.:..   |..::|..|.|.||.          :|          .|..||:|..::
Human   139 IRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKG 203

  Fly   243 ----LIPL------QAWAAKASASFGTRSAKHRDARVK---LMNEIIGAIQ-VIKMYAWEKSFGR 293
                |:.|      .|.||..|....:.::|...|..|   :..|::.:|: ||...|.||...|
Human   204 WKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQR 268

  Fly   294 LIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGL--- 355
            ....::.::...|:.:::           ||:||     ..||          |.::..|||
Human   269 YTQNLKDAKDFGIKRTIA-----------SKVSL-----GAVY----------FFMNGTYGLAFW 307

  Fly   356 ------LND--------------SLLH--YWPMAITTWAQTLVSARRVVEFLLQV--EKPTEESC 396
                  ||.              |::|  |...|.....:|...||.....:.||  :||:.::
Human   308 YGTSLILNGEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSIDN- 371

  Fly   397 CRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASW-DKPSIKQPRKPHIEGISFHINAG 460
                  ......||:..:.           .:.|:.||.:: .:||||     .::|::..|.:|
Human   372 ------FSTAGYKPESIEG-----------TVEFKNVSFNYPSRPSIK-----ILKGLNLRIKSG 414

  Fly   461 QFVGIVGNVGSGKSTLLHAILGEIELMQGRVEV-----------HGR--ISYAAQQPWVFQGSIR 512
            :.|.:||..||||||::..:....:...|.:.|           |.|  |...:|:|.:|..:|.
Human   415 ETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTIS 479

  Fly   513 ENILF--VEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQA 575
            .||.:  .:..:|:..||...|...|..:| .|....|:|||:|..:|||||.|||:|||:.|..
Human   480 NNIKYGRDDVTDEEMERAAREANAYDFIME-FPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNP 543

  Fly   576 DIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYE 640
            .|.:.|:..:|:|:: .|..:.....:...|:..|:|.|.:..::|.|.::.|:.|.|.::|::.
Human   544 KILILDEATSALDSE-SKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHA 607

  Fly   641 EL--KDVITHHAALDLEAIEADKQQVKRVLSQVDRT------------SKQLSKGEEKDPATIQD 691
            ||  |..:.:...:..:..:||:|......|...:|            |..:.|.||   :|...
Human   608 ELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEE---STQSK 669

  Fly   692 ENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYD 756
            |....|..|...:..:..:       .||:|...|:. ||......|..|..::..|...:....
Human   670 EISLPEVSLLKILKLNKPE-------WPFVVLGTLAS-VLNGTVHPVFSIIFAKIITMFGNNDKT 726

  Fly   757 SVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFF--------MCLRISLTLHDQLYHGIIRAW 813
            :: .::|....|:  :.:|.::....:.::  |.|:        |.|| .|.....||..|  ||
Human   727 TL-KHDAEIYSMI--FVILGVICFVSYFMQ--GLFYGRAGEILTMRLR-HLAFKAMLYQDI--AW 783

  Fly   814 MYFFNANPSGRVLNRFSSDIQNVD--------------VNLPQAMMDS------LQFLVDVVAVL 858
             :....|.:|.:....:.||..:.              .|:..:::.|      :.||  ::::.
Human   784 -FDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFL--ILSIA 845

  Fly   859 VIVAIANYWLLIPAAIMVIL-------LYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHS 916
            .::|:..   :|..|.|...       |.....:...|..:::.|.||||...:....:
Human   846 PVLAVTG---MIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYE------ 901

  Fly   917 TIRSMDAMPQLEQTFHGHQNTNSSA-----------LFLYVSANRAFSFWTDLI---------CV 961
                     ::.||  .|:||:..|           .|:|.:....|.|...||         ..
Human   902 ---------EMLQT--QHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMF 955

  Fly   962 IYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSE 1026
            |...|:.:..:.|.:               |||:..::     ::.::....:..:||     .:
Human   956 IVFTAIAYGAMAIGE---------------TLVLAPEY-----SKAKSGAAHLFALLE-----KK 995

  Fly  1027 PPLESPKSVNLAAEWPQAGHLRFQDLRMRY--SPGDEDILRGLNFESQPMEKIGIVGRTGAGKSS 1089
            |.::|........:..: |:|.|:::...|  .| |..|||||:...:..:.:..||.:|.|||:
Human   996 PNIDSRSQEGKKPDTCE-GNLEFREVSFFYPCRP-DVFILRGLSLSIERGKTVAFVGSSGCGKST 1058

  Fly  1090 IIQALFRL-ALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLW 1153
            .:|.|.|| ...:|.:..||:|..:|.:..|||:|:|:||:||||:.::..|:    ...|.|..
Human  1059 SVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENI----AYGDNSRV 1119

  Fly  1154 SALDDVKLKKHVAS----LEG---------GLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLV 1205
            ..||::|...:.|:    :||         ||.      |:..|.||:|.:.:|||:|::.::|:
Human  1120 VPLDEIKEAANAANIHSFIEGLPEKYNTQVGLK------GAQLSGGQKQRLAIARALLQKPKILL 1178

  Fly  1206 MDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQR 1270
            :||||:.:|.:::.::|..:.......|.|.:.|||..:.:.|.::|:..|:|.|.|...:||:.
Human  1179 LDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRN 1243

  Fly  1271 KDGALLKLVN 1280
            :| ...||||
Human  1244 RD-IYFKLVN 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	303/1361 (22%)
		ABC_membrane	95..360	CDD:294371	66/348 (19%)
		ABCC_MRP_domain1	428..632	CDD:213217	66/219 (30%)
		ABC_membrane	728..994	CDD:294371	54/320 (17%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	75/234 (32%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PTZ00265	8..1251	CDD:240339	307/1372 (22%)
		ABC_membrane	52..333	CDD:279056	67/349 (19%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	72/243 (30%)
		ABC_membrane	696..962	CDD:279056	53/297 (18%)
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216	80/249 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000