Protein Alignment CG10505 and Sur

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_061511301.1
• Gene: Sur / 3292067
• VectorBaseID: AGAMI1_003204
• Length: 2282
• Species: Anopheles gambiae
• Alignment Length: 1591
• Identity: 391/1591 - (24%)
• Similarity: 619/1591 - (38%)
• Gaps: 503/1591 - (31%)

  Fly   188 GQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIG-IAFIVILIPLQAWAA 251
            |...::||.|...........|.:|..|::..:..||:.||:|.:::|| :..||.:.|||....
Mosquito   699 GTITNLMSDDAFNVMSFVKMVHYVWAIPLKIAVVMYLLYRQLGISTVIGSVVCIVTMTPLQLLIG 763

  Fly   252 KASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAAL 316
            |..|:...:.::..|.|::.:||::..|::||:.|||..|...|:..||.|::.: ...|||..|
Mosquito   764 KLMAANSKKVSECTDERLRRINEVLLGIKLIKLNAWETVFKDKISQARQQELRHL-DLDSIYWTL 827

  Fly   317 Q--CTNMISKISLFLSLVAYVYVGD---LVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLV 376
            .  .|::.|.:...:::..::.:.:   .:||.::|...:.:..|...|. .:|:.|......:|
Mosquito   828 MMLLTHISSVLITIVTIAVFLALENNPIELTAGRLFASLALFNQLTVPLF-IFPITIPITLSAIV 891

  Fly   377 SARRVVEFLLQ--VEKPT-----------------------------------EESCCRDNPGLE 404
            |..|:..||.|  ||:.:                                   :|.|    ||:.
Mosquito   892 STGRLEAFLGQPEVERSSLEGIRTMARILSKSDASLDMDEAGDPQYGDDAAAAQEQC----PGVP 952

  Fly   405 LDAEKPKPAQSGR---------------------------------------------------- 417
            :.| .|...:.|:
Mosquito   953 VVA-PPDQVEEGQQLQQPGIKSSDNVTGSPQTERKAADNAGPLPLVEDVGGKSCSQHSSMSSDRS 1016

  Fly   418 LHCVQSETKCLSFRKVSASWDK--PSIKQPRKPHIE-----------------------GISFH- 456
            :.|.|.:...:: |:..|.:.|  ||.:...|.|.:                       |:..|
Mosquito  1017 IRCEQVDRAPMA-RQRPAKYQKTVPSPRVKLKKHSQLSVSARLEKCRQKQKHLAREMRFGLPDHA 1080

  Fly   457 -------------------------------INAGQFVGIVGNVGSGKSTLLHAILGEIELMQGR 490
                                           :...:...|||..|||||:||.|:|.||..:.|.
Mosquito  1081 AVFLKDARFRWNDTGADDTMAHCALHIEQLTVPKAKLTVIVGRSGSGKSSLLAALLKEINHLSGE 1145

  Fly   491 V--EVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGER 553
            :  ..:..|:|..|:||:...:||||:||.|.:..|||..|:.||.|..||:|:|.||.|.:|||
Mosquito  1146 LIWNKYSSIAYVPQKPWLQNATIRENVLFGESFRPKRYDRVLRACALKPDLDLMPAGDGTEIGER 1210

  Fly   554 GISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMR--ILVTHHV 616
            |:.|||||:.|||:|||:|..|::.:.||||:|:|.:|...:.:...||:|..:.|  ||||..|
Mosquito  1211 GLKLSGGQRQRIAIARALYSSANVVILDDPLSALDNEVAMDVFENGVHRMLARQKRTIILVTQKV 1275

  Fly   617 QLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLEAIEADKQQ------------------ 663
            ||:...|.::::|||.::..||..|:::... |...:..||.|.:||
Mosquito  1276 QLVHRADNIVVMEGGTVSATGSLTEIENNYP-HILREWNAIIAKEQQQSSEAQSSPGRTARERWK 1339

  Fly   664 ----VKRVLSQ----------VDRT---------------------------------------- 674
                :.|:..|          ::||
Mosquito  1340 LFKNISRISFQRNHATEENDFMERTFYFPRTMANRALFGSRFSAHDFPLPIEDCHEPNVALRRHY 1404

  Fly   675 SKQLSK----------------GEEKDP-------------------ATIQDENGNAEQQLQ--- 701
            |.:|.|                |:.:.|                   ||......|..||.|
Mosquito  1405 SNRLRKDSPPSSTAVVLRRPPLGQIEHPPGTGHQSVFRALSLQLGTNATTSSSTVNQRQQRQPAV 1469

  Fly   702 --------------GAVSYDT-------------YKAYFRALGA--------------------- 718
                          ||:..||             :.....:.||
Mosquito  1470 VVRHISFPTTLTSSGALDDDTLYRKRLNQGGTAAHPGQLASAGALSGQRRMLASTDDTGMDGIEP 1534

  Fly   719 -------------------------PFLVCLVLSMFVL-------------------------AR 733
                                     .|.:...|....|                         :|
Mosquito  1535 NRTGVLLYGQNEGRNSCEDLKRSSIGFRIPEFLRRMSLRGRRFSNPTEFGRPYREREDGSRKSSR 1599

  Fly   734 GCQAVMDI----------FISRWATWEEDRGYDSVDDYEATRTKMVIW----------------- 771
            ...::..|          .:|..:...||....|||..||..:..:|:
Mosquito  1600 KTSSLKSIPKERHYSIKRLLSTISRQSEDTEESSVDYGEAEVSNRLIYDDERKYGRIPARMYWLY 1664

  Fly   772 --------YTVLLLLTLALFLLRTFGFFFM----------------------------------- 793
                    ..:..|..||...|:.:..|::
Mosquito  1665 LISCGPRMVAIFFLSALAQQALKVYTDFWLQEWTDQTATISTIVVPTNGTVADASSPTKPLEIRR 1729

  Fly   794 -----------CLRISL---------------TLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSD 832
                       |:.::.               .||.:|...:::..::||.:.|.||::||.|.|
Mosquito  1730 HFHAYVALSAVCIVLAAISVPAGQRAGSNARRRLHRELIASVLQNSIHFFQSVPLGRIMNRLSID 1794

  Fly   833 IQNVDVNLPQAMMDSLQF-LVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRI 896
            :..||..:.......||| |:.|.|||:...:..|::|:...|..| .|..:..|..:||.|:||
Mosquito  1795 VAVVDKKIAATSQKLLQFILLCVCAVLINSVVTPYFILLTIPICGI-YYMVQKFYRASSRELQRI 1858

  Fly   897 ESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANR----AFSFWTD 957
            ||:|.||:.:|.::|..|.:|||:.....:..:........|:.|......:||    |..:...
Mosquito  1859 ESMTYSPVLAHFSETIEGVTTIRAFGQEARFMEVLFKRMEANNVAQLALNCSNRWLGIALDYLGA 1923

  Fly   958 LICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEY-- 1020
            :|..:.||....:..:..||..|..:|||:..:|.:.|...|.::..||||....:|||:..:
Mosquito  1924 IIVFVAILTALITASLRPQSTSSSLIGLAVNYAMLVPIYLNWVVKLFAEMEMYGGAVERIQSFIE 1988

  Fly  1021 -------------------AQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRG 1066
                               .|.....|. |.|:|.::  ||..|.:.::.:.:||....|:|:..
Mosquito  1989 CDVQRRRLDGGLRGRSSRVVQDTGVVPF-SYKTVPIS--WPLRGVIVYEGVSLRYENQKENIITN 2050

  Fly  1067 LNFESQPMEKIGIVGRTGAGKSSIIQALF-RLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDP 1130
            ||......:::||.||||:||||:..||| .|.:..|.|.||.:||..|...:||||:|||||:.
Mosquito  2051 LNLTIPAGQRLGICGRTGSGKSSLALALFGALEITAGRILIDDVDIAGLHTDELRSRLSIIPQEV 2115

  Fly  1131 VLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLAR 1195
            :||.|::|.||||....||..||:.|:..:||..|.||..||..::.|....||.|||||.||||
Mosquito  2116 MLFGGSVRENLDPRGHFSDLELWNCLELAQLKNVVMSLPDGLDTQISDDKHYFSSGQRQLFCLAR 2180

  Fly  1196 AILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVE 1260
            ||||.:..||:||||:::||||:.|:.:..:..|...||:|||||||:::|.:.|||::.|:|||
Mosquito  2181 AILRGSVCLVLDEATSSLDTETEKLVLQAAKKAFKGRTVITIAHRLHSLVDYERVLVLEQGRIVE 2245

  Fly  1261 FGAPHKLLQR---KDGALLKLVNQNDATTVK 1288
            .|.|.||..:   |.|.:||..:......|:
Mosquito  2246 DGCPRKLAGKPGSKFGTMLKATDHQQHAIVE 2276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	386/1572 (25%)
Sur	XP_061511301.1	None