DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc3

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_009304645.1	Gene:	abcc3 / 323301	ZFINID:	ZDB-GENE-050517-16	Length:	1540	Species:	Danio rerio

Alignment Length:	1397	Identity:	457/1397 - (32%)
Similarity:	722/1397 - (51%)	Gaps:	195/1397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSPKRESN--PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWE- 68
            ||...:.|  |...|..:|:..|.|...:..||.:..|:...|:....:..||.:...|...||
Zfish   194 SSAVMDPNVCPETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEV 258

  Fly    69 --------------------------------------------KESKKKNPSLMRLIFKVYGWQ 89
                                                        ::.|.:.||.:..:.:.:|..
Zfish   259 EKSKAHSSDDQNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAFGPY 323

  Fly    90 FVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESA----YLYAMGIVL--CSLVTSLV 148
            |: :...:.||:..|....|.||..||::        ||:|.    :.||:..::  .||:.:|:
Zfish   324 FL-IGSAFKLLQDLITFINPQLLRMLIAF--------TKQSDVPSWWGYALAFLMFGTSLLQTLI 379

  Fly   149 FHPFMFYVFAVGTRVRLACAGLVYRKCL----RASASSGEGLGGQAISVMSIDLSQF-DLTFYFF 208
            .|....|.|..|.|:|....|.:|||.|    .|..||   ..|:.:::||:|..:| ||| .|.
Zfish   380 LHQHFQYCFVTGMRLRTGIIGAIYRKALVITNEAKRSS---TVGEVVNLMSVDAQRFMDLT-TFL 440

  Fly   209 HDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMN 273
            :.||..|::..:..:.:.:.:|.:.|.|:|.:|:|||..|:.|..:.::.....|::|.|:||||
Zfish   441 NMLWSAPLQIFLALFFLWQNLGPSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMN 505

  Fly   274 EIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGS--MSIYAALQCTNMISKISLFLSLVAYVY 336
            ||:..|:|:|:||||.||...|..:||.|:..:|.:  :|..:.:..|:....::| .|...:|.
Zfish   506 EILNGIKVLKLYAWEPSFRDKILQIRQKELHVLRKTAYLSALSTMAWTSAPFLVAL-TSFAVFVN 569

  Fly   337 VGD--LVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRD 399
            |.:  ::.|:|.|:..|.:.:|... |:..|..|::..|..||.:|:.:||...|...|....:.
Zfish   570 VDEKNVLDAEKAFVSLSLFNILRFP-LNMLPQVISSIVQASVSLKRLQDFLNHDELDPESVDRKS 633

  Fly   400 NPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVG 464
            |     ..|......:|:.                 ||.|..     :..::.|:..:..|..:.
Zfish   634 N-----TTEYAVSVVNGKF-----------------SWAKRD-----QVILDNINVLVPQGSLLA 671

  Fly   465 IVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAV 529
            :||:||.||::|:.|:|||:|.:.|::.:.|.::|..||.|:...::|:||||...|.|::||.|
Zfish   672 VVGHVGCGKTSLISALLGEMEKLDGQISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCV 736

  Fly   530 VHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKL 594
            :.||.|..|||:||.||.|.:||:||:|||||:.|::||||:|.:||:||.||||:||||.|.|.
Zfish   737 LEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKH 801

  Fly   595 LMDKCF--HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL--------------- 642
            :.|...  ...|.||.||||||.:..|..|:.:|:|..|::::.|||::|
Zfish   802 IFDHVIGPEGALKGKTRILVTHGISFLPQVNNILVLVDGRVSEMGSYQDLLRQNGAFAEFLRNYS 866

  Fly   643 ----------------------KDVITHHA-ALDLEAI--EADKQQVKR--VLSQVDRTSKQLSK 680
                                  :|.:::|. .:|.|.:  ||.:|.:::  ::|......|::|:
Zfish   867 LEDIIEDDELTVSFDEEEEEFPEDALSNHTDMVDNEPVVNEARRQFMRQMSIMSNDVENPKKMSR 931

  Fly   681 ----GEEKDPAT-IQDENGNAEQQLQ------GAVSYDTYKAYFRALGAPFLVCLVLSMFVLARG 734
                .|.|.|.| .:.:....|:.:|      |.|....|..|.:|:| |.|...:..::    |
Zfish   932 RRRCSERKHPETPTEKKEPKVEKLIQAETTETGRVKLQVYWEYVKAIG-PLLALFICFLY----G 991

  Fly   735 CQAVMDIFISRW-ATWEEDRGYDSVDDYEATRTKMVIWYTVL------LLLTLALFLLRTFGFFF 792
            ||:...|..:.| :.|..|..::...:...||..:   |..|      |:|::.| |.|.:.
Zfish   992 CQSAAAIGANFWLSEWTNDALHNRTQEMLQTRVGV---YAALGISQGVLILSICL-LCRAYS--- 1049

  Fly   793 MCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAV 857
             .||.:...|..:.:.::||...||.|.||||||||||.|:..:|..:|..:...::.....|.|
Zfish  1050 -TLRAARHTHQHMLNSVLRAPQAFFEATPSGRVLNRFSKDVDTIDSLIPDNIDIWMRTFWYTVNV 1113

  Fly   858 LVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMD 922
            |::.::.....||....:::..::.:..|:..||.|||:||::|||||||.:::..|.|.||:..
Zfish  1114 LMVCSVLTPIFLIVIVPLMLFYWWVQRFYVATSRQLKRLESVSRSPIYSHFSESITGTSVIRAYG 1178

  Fly   923 AMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLI--CVIYILAVTFSFLVINQSFYS-GDVG 984
            .............:.|..:.:..:.:||......:.|  |::...|:   |.|..:...| |.||
Zfish  1179 RNAAFVLMSDNKVDENQKSYYPGIVSNRWLGVRIEFIGNCIVLFAAL---FAVTGKDKLSPGLVG 1240

  Fly   985 LAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLE----SPKSVNLAAEWPQAG 1045
            |:::.::.:.:...|.:|.|:::|:|:.:||||.||::|.:|.|.|    .|     ..:||..|
Zfish  1241 LSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETQTEAPWEVLEKKP-----PPDWPPLG 1300

  Fly  1046 HLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTIEIDGL 1109
            ::.|.|..:||..|.:.:|:.::.:.:..|||||||||||||||:...||| |....|.|.||.:
Zfish  1301 NVEFVDYSVRYREGLDLVLKNISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDV 1365

  Fly  1110 DIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSC 1174
            .|.::|||||||:::||||:|||||||||.|||||:..|||.:|.||:...|:|.|.:....|..
Zfish  1366 KISEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFVTNQAAKLEL 1430

  Fly  1175 RMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAH 1239
            ...:||.|.|:|||||||||||:||:.|:||:|||||.||.|||.|||.||:|:|.:|||.||||
Zfish  1431 ECSEGGENLSVGQRQLVCLARALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAH 1495

  Fly  1240 RLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRK 1271
            ||:|:||...|||:|.|||.||..|..|:.:|
Zfish  1496 RLNTIMDYTRVLVLDKGQIAEFDTPTNLMNQK 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	453/1387 (33%)
		ABC_membrane	95..360	CDD:294371	86/279 (31%)
		ABCC_MRP_domain1	428..632	CDD:213217	87/205 (42%)
		ABC_membrane	728..994	CDD:294371	74/275 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	124/219 (57%)
abcc3	XP_009304645.1	MRP_assoc_pro	10..1539	CDD:188098	457/1397 (33%)
		ABC_membrane	330..595	CDD:279056	86/278 (31%)
		ABCC_MRP_domain1	640..841	CDD:213217	88/222 (40%)
		ABC_membrane	985..1253	CDD:279056	74/282 (26%)
		ABCC_MRP_domain2	1300..1520	CDD:213211	124/219 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.760