DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcb5

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_006240775.1	Gene:	Abcb5 / 314537	RGDID:	1566342	Length:	1255	Species:	Rattus norvegicus

Alignment Length:	1333	Identity:	287/1333 - (21%)
Similarity:	542/1333 - (40%)	Gaps:	300/1333 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 ILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAY------------------LYAMGIVLC 141
            ||.|::..|......|:||.:..:|..|....|.::.|                  ||.:||...
  Rat    53 ILASMINGATVPLMSLVLGEISDHFINGCLVQTNKTKYQNCSQSQEKLNEDIIMLTLYYVGIGAA 117

  Fly   142 SLVTSLVFHPFMFYVFAVG---TRVRLACAGLVYRKCLRASASSGEGLGGQAISVMSIDLSQFDL 203
            :||...|  ...|:|....   ||:|        ::...              |:::.|:|.||.
  Rat   118 ALVLGYV--QISFWVITAARQTTRIR--------KQFFH--------------SILAQDISWFDG 158

  Fly   204 TFYFFHDLWKGPVEACIFGYLMTRQVG----------------WTSLIGIAFIVILIPLQAW--- 249
            |            :.|   .|.||..|                :.::.|.:..:::..:::|
  Rat   159 T------------DIC---ELNTRMNGDISKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLS 208

  Fly   250 -------------AAKASASFGTRSAKHRDARVK---LMNEIIGAIQVIKMY-AWEKSFGRLIAA 297
                         :|..|....:.::|..||..|   :..|.:.:|:.:..: |.||...|....
  Rat   209 LAILSTSPLIMAASALCSRMVISLTSKELDAYSKAGAVAEEALSSIRTVTAFGAQEKEIQRYTQN 273

  Fly   298 VRQSEVKAIRGSMSIYAALQCTNMISKISL-----FLS---LVAYVYVGDLVTAKKV-----FIL 349
            ::.::...|:.:::           ||:||     |::   .:|:.|...|:...:.     .||
  Rat   274 LKDAKDAGIKRAIA-----------SKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTVGTIL 327

  Fly   350 SSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQV--EKPTEESCCRDNPGLELDAEKPKP 412
            :.::.:::.|   |...::....:|...||.....:..|  :||..::       ......||:.
  Rat   328 AVFFSVIHSS---YCIGSVAPHLETFTIARGAAFNIFHVIDKKPNIDN-------FSTAGYKPES 382

  Fly   413 AQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLL 477
            .:..           :.|:.||.|:  ||  :|....::|.:..|.:|:.|.:||..||||:|.:
  Rat   383 IEGN-----------IEFKNVSFSY--PS--RPSAKILKGFNLKIKSGETVALVGPSGSGKTTTV 432

  Fly   478 HAILGEIELMQGRVEV-----------HGR--ISYAAQQPWVFQGSIRENILFVEQ--YEEKRYR 527
            ..:....:..:|.:.|           |.|  |...:|:|.:|..:|..||.|..:  .||:..:
  Rat   433 QLLQRLYDPEEGCITVDENDIRTQNVRHYREQIGVVSQEPVLFGTTIGNNIKFGREGVSEEEMEQ 497

  Fly   528 AVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVG 592
            |...|...| .:...|:...|:|||:|..:|||||.|||:|||:.|...|.:.|:..:|:|.: .
  Rat   498 AAREANAYD-FIMAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTE-S 560

  Fly   593 KLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL--KDVITHHAALDLE 655
            :.|:.....:...|:..::|.|.:..::..|.::.::.|::.::|.:.||  |..:.:..|:..:
  Rat   561 ESLVQAALEKASKGRTTLVVAHRLSTIRGADLIVTMKDGEVVEKGIHAELMAKQGLYYSLAVAQD 625

  Fly   656 AIEADKQQVKRVLSQVDRTS--KQLSKGEEKDPATIQDENGNAEQQLQ-GAVS----YDTYKAYF 713
            ..:.|:|...|..|.....|  ...:....|.|.|.|.|.....|:.. ..||    :...|:.:
  Rat   626 IKKVDEQMESRTCSAAGNASNGSLCNVNSAKSPCTDQFEEAVPHQKTTLPEVSLLKIFKLSKSEW 690

  Fly   714 RALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLL 778
                 ||:|...|:. .|.........|...:..|..||:...::.......:.|::   ||.::
  Rat   691 -----PFVVLGTLAS-ALNGSVHPAFSIIFGKLVTMFEDKNKTTLKQDAELYSMMLV---VLGIV 746

  Fly   779 TLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNA------NPSGRV------------ 825
            .|..:|::  |.|:.  |....|..:|.|...:|.:|...|      |.:|.:
  Rat   747 ALVTYLMQ--GLFYG--RAEEILAMRLRHSAFKAMLYQDMAWYDEKDNSTGALTTTLAVDVAQIR 807

  Fly   826 ------LNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVIL------ 878
                  |...:.|:.|:.:::..:.:...:..:.:::...|:|:..   :|..|.|...
  Rat   808 GAATSRLGIITQDVTNMSLSILISFVYGWEMTLLILSFAPILAVTG---MIQTAAMAGFANKDKQ 869

  Fly   879 -LYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQN------ 936
             |.....:...|..:::.:.||||...:.|..:     .|:|:.            |:|
  Rat   870 ELKRAGKIATEAVENIRTVVSLTREKAFEHMYE-----ETLRTQ------------HRNALKRAH 917

  Fly   937 -TNS----SALFLYVSANRAFSFWTDLI---------CVIYILAVTFSFLVINQSFYSGDVGLAI 987
             |.|    |..|::.:....|.|...||         ..|...|:.:..:.|.:
  Rat   918 ITGSCYAVSHAFVHFAHAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGE----------- 971

  Fly   988 TQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQA--GHLRFQ 1050
                |||    |.      .|.:.........:|...::|.::   |.:...|.|.|  |:|.|:
  Rat   972 ----TLV----WA------PEYSKAKAGAAHLFALLKNKPSID---SCSQNGEKPDACEGNLEFR 1019

  Fly  1051 DLRMRYSPGDE-DILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRL-ALNEGTIEIDGLDIGK 1113
            ::...|....| .:|:.::...:..:.:..||.:|.|||:.:|.|.|. ...:|.:.:||:|:.:
  Rat  1020 EVSFFYPCRPEVPVLQDMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKE 1084

  Fly  1114 LGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVK-------LKKHVASLEGG 1171
            |.:..|||:.:|:.|:||||:.::..|:    ...|.|....|:::|       :...:..|.|.
  Rat  1085 LNVQWLRSQTAIVSQEPVLFNCSIAENI----AYGDNSRMVPLEEIKEVADAANIHSFIEGLPGK 1145

  Fly  1172 LSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLT 1236
            .|.::...|.:.|.||:|.:.:|||:||:.::|::||||:.:|.|::.::|:.:.......|.|.
  Rat  1146 YSTQVGLRGMHLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKMVQQALDKARRGRTCLV 1210

  Fly  1237 IAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            :||||.|:.:.|.::|:..|:|.|.|...:||:
  Rat  1211 VAHRLSTIQNADMIVVLQNGRIKEQGTHQELLR 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	285/1330 (21%)
		ABC_membrane	95..360	CDD:294371	59/334 (18%)
		ABCC_MRP_domain1	428..632	CDD:213217	62/218 (28%)
		ABC_membrane	728..994	CDD:294371	52/316 (16%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	68/227 (30%)
Abcb5	XP_006240775.1	PTZ00265	48..1252	CDD:240339	287/1333 (22%)
		ABC_membrane	53..334	CDD:279056	59/330 (18%)
		ABC_MTABC3_MDL1_MDL2	387..624	CDD:213216	68/242 (28%)
		ABC_membrane	697..963	CDD:279056	51/293 (17%)
		ABC_MTABC3_MDL1_MDL2	1017..1254	CDD:213216	68/231 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000