DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcc12

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_008770597.1	Gene:	Abcc12 / 291923	RGDID:	735100	Length:	1378	Species:	Rattus norvegicus

Alignment Length:	1374	Identity:	439/1374 - (31%)
Similarity:	713/1374 - (51%)	Gaps:	153/1374 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKKKNP-- 76
            ||...|.::|...|.|:..|..:..:..|....|....|...|:...:.||..|::|.::..|
  Rat    44 NPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDVNAKRLQILWDEEIERVGPER 108

  Fly    77 -SLMRLIFKVYGWQF----VPVCILYSLLEMAIHSFQP-LLLGGLISYFAYGQTTVTKESAYLYA 135
             ||.|::     |:|    |.:.::.::|.:.:.:..| :|:..::.:       ||..|:....
  Rat   109 ASLGRVV-----WKFQRTRVLMDVVANILCIIMAALGPTVLIHQILQH-------VTNISSGHIG 161

  Fly   136 MGIVLCSLVTSLVFHPFMFYVFA------VGTRVRLACAGLVYRKCL------RASASSGEGLGG 188
            :.|.||..:.:..|...:|:..|      ...|:::|.:.|:::..|      ..||       |
  Rat   162 ISICLCLALFATEFTKVLFWALAWAINYRTAIRLKVALSTLIFKNLLSFKTLTHISA-------G 219

  Fly   189 QAISVMSID-LSQFDLTFYFFHDLWKGPVEA---------CIFGYLMTRQVGWTSLIGIAFIVIL 243
            :.::|:|.| .|.|:...:.       |:.|         .::.:.:   :|.|:|:||...:|.
  Rat   220 EVLNVLSSDSYSLFEAALFC-------PLPATIPILMVVCAVYAFFI---LGSTALVGICVYLIF 274

  Fly   244 IPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRG 308
            ||:|.:.||.:::|...:....|.||:.|||.:..|::||||||||||...|..:|:.|.|.:..
  Rat   275 IPIQMFMAKLNSAFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEKSFMNTIHDIRKREKKLLEK 339

  Fly   309 S---MSIYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITT 370
            :   .|..:||  ..::|.|::..:...::::...:||...|.:.:.:.::..|:. ..|.::..
  Rat   340 AGYVQSGNSAL--APIVSTIAIVSTFTCHIFLKRTLTAPVAFSVIAMFNVMKFSIA-ILPFSVKA 401

  Fly   371 WAQTLVSARRVVEFLLQVEKPTEESCCRD--------NPGLELDAE-----KPKPAQSGRLHCVQ 422
            .|:..||.||:.:.|:....|:..:...|        |..|..:.|     .|...|..|.|.
  Rat   402 VAEASVSLRRMKKILVAKSPPSYITQPEDPDTILLLANATLTWEQEINRKRGPLKTQDQRRHV-- 464

  Fly   423 SETKCLSFRKVSA------SWDKPSIKQPR------KPHIEGISFHINAGQFVGIVGNVGSGKST 475
                   |:|..|      |.....:..|.      |..:..|||.:..|:.:||.||||||||:
  Rat   465 -------FKKQRAELYSEQSLSDQGVASPERQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSS 522

  Fly   476 LLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLE 540
            |:.|:||:::|.:|.|.|.|.::|.:||.|:|.|::||||||.|:|..:||:..||.|.|.:||.
  Rat   523 LISALLGQMQLQKGVVAVSGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLN 587

  Fly   541 LLPRGDAT-------VVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDK 598
            .||.||.|       .:||||::|||||:.||:||||||....:||.||||:||||.|||.:.::
  Rat   588 SLPYGDLTECHYPHLQIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEE 652

  Fly   599 CFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAAL--DLEAIE-AD 660
            |..:.|.||..:||||.:|.|:|.|:::|||.|::.::|:::||.:....:|.|  :|..:: .|
  Rat   653 CIKKTLKGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKD 717

  Fly   661 KQQVKRVL-------SQVDRTSKQ-LSKGEEKD----PATIQ--DENGNAEQQLQ------GAVS 705
            .:.:..|.       ||..|.... |:.|:|:|    |.|.:  |......|.:|      |.|:
  Rat   718 PEHIYNVAMVETLKESQAQRDEDAVLASGDERDEGKEPETEEFVDIKAPVHQLIQIESPQEGIVT 782

  Fly   706 YDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW---------ATWEEDRGYDSVDDY 761
            :.||..|.:|.|...:..|||.:|.|..|..|....::..|         |....:...:.....
  Rat   783 WKTYHTYIKASGGYLVSFLVLCLFFLMMGSSAFSTWWLGLWLDSGSQVICAPQSNETACNVNQTL 847

  Fly   762 EATRTKMV-IWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRV 825
            :.|:..|. :.|...::..|...:::.|.|....|..|.:||:::::.|:.:.|.||:..|:||:
  Rat   848 QDTKHHMYQLVYIASMMSVLTFGIIKGFTFTNTTLMASSSLHNRVFNKIVSSPMSFFDTTPTGRL 912

  Fly   826 LNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGAS 890
            :||||.|:..:||.||....:.||....||.:|||:|.:...:|:..|.:.||.:....::....
  Rat   913 MNRFSKDMDELDVRLPFHAENFLQQFSMVVFILVIMAASFPVVLVVLAGLAILFFILLRIFHRGV 977

  Fly   891 RSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFW 955
            :.||::|:::|||.:||...:..|...|.:.|........|....:.|||.|..:..|.|.|:..
  Rat   978 QELKQVENISRSPWFSHITSSMQGLGVIHAYDKKDDCISKFKALNDENSSHLLYFNCALRWFALR 1042

  Fly   956 TDLI--CVIYILA--VTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVER 1016
            .|::  .|.:::|  ||.||..|:.|    ..||:::..:.|..:.|..:|...|.:...||.|.
  Rat  1043 MDILMNIVTFVVALLVTLSFSSISAS----SKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAEL 1103

  Fly  1017 VLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVG 1081
            :.||..|......:|.|......:||..|.:.|:|.||||......:|.|||...|..:.:||||
  Rat  1104 MREYISTCVPEHTQSFKVGTCPKDWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVG 1168

  Fly  1082 RTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFD 1145
            |||:||||:..|||||. ...|||.||.:||..:||.:||:::::||||||||.||:|:||||..
  Rat  1169 RTGSGKSSLGMALFRLVEPASGTIFIDEVDICTVGLEELRTKLTMIPQDPVLFVGTVRYNLDPLG 1233

  Fly  1146 EKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEAT 1210
            ..:||.||..|:...::..:..|...|...:.:.|.|||:|:|||:|:|||:||.::::::||||
  Rat  1234 SHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEAT 1298

  Fly  1211 ANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQ-----IVEFGAPHKLLQR 1270
            |::|::||.|:|.||:..|..||||||||||:||::.|.||||:.|:     ::||..|..|.::
  Rat  1299 ASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVQEVLVIEFDKPEVLAEK 1363

  Fly  1271 KDGALLKLV 1279
            .|.|...|:
  Rat  1364 PDSAFAMLL 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	435/1361 (32%)
		ABC_membrane	95..360	CDD:294371	67/290 (23%)
		ABCC_MRP_domain1	428..632	CDD:213217	101/222 (45%)
		ABC_membrane	728..994	CDD:294371	74/279 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	108/224 (48%)
Abcc12	XP_008770597.1	CFTR_protein	44..1348	CDD:273530	432/1348 (32%)
		ABC_membrane	127..388	CDD:294371	67/286 (23%)
		ABCC_MRP_domain1	487..686	CDD:213217	96/198 (48%)
		ABC_membrane	802..1084	CDD:294371	77/285 (27%)
		ABCC_MRP_domain2	1132..1357	CDD:213211	108/224 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660