DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcc6

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_006541009.1	Gene:	Abcc6 / 27421	MGIID:	1351634	Length:	1500	Species:	Mus musculus

Alignment Length:	1254	Identity:	366/1254 - (29%)
Similarity:	593/1254 - (47%)	Gaps:	152/1254 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWE 68
            |:.|.|.... |..:|:..||.:|.|...:..:|.::.|....|:.......||.|...|:..|.
Mouse   268 SEDSQPLNPC-PEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWR 331

  Fly    69 K-------------------------ESKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQ 108
            :                         |..::.| |:|.|::|:...|     |...|.:.|....
Mouse   332 RSCNGLPGHKGHSSVGAPETEAFLQPERSQRGP-LLRAIWRVFRSTF-----LLGTLSLVISDAF 390

  Fly   109 PLLLGGLISYFA--YGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLV 171
            ...:..|:|.|.  .|....:..:.:|.|:.:...:.:.:|.....|:....:..|:|.|..|||
Mouse   391 RFAVPKLLSLFLEFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLV 455

  Fly   172 YRKCL-RASASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYL------MTRQV 229
            |||.| .:|.|......|..::::|:|:.:...:..:.:.||      .:|.::      :.:.:
Mouse   456 YRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLW------LLFLWIFVCFVYLWQLL 514

  Fly   230 GWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRL 294
            |.::|..:|..:.|:||..:..|..........:.:.:|.:|.:.::..::.||.:.||.:|...
Mouse   515 GPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLER 579

  Fly   295 IAAVRQSEVKAIRGSMSIYAALQCTNMIS-KISLFLSLVAYVYVGDLVT------AKKVFILSSY 352
            :..:|..|:.|::.|..:::    .:::| ::|.||..:....|..||.      |:|.|:..:.
Mouse   580 LLHIRGQELSALKTSTLLFS----VSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTV 640

  Fly   353 YGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGR 417
            ..:||.:.. :.|.::....|..||..|:..||           |.:    |:|......:.|.|
Mouse   641 LSILNKAQA-FLPFSVHCIVQARVSFDRLAAFL-----------CLE----EVDPNGMIASNSRR 689

  Fly   418 LHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILG 482
                 |....:|....:.:|.:.|     .|.:.||:..:..|..:.:||.||:|||:||.|:||
Mouse   690 -----SSKDRISVHNGTFAWSQES-----PPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLG 744

  Fly   483 EIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDA 547
            |:..::|.|.:.|.::|..|:.||...|:.||:.|.::.:....:.|:.||.|..|:...|.|..
Mouse   745 ELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVH 809

  Fly   548 TVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRI 610
            |.:||:|::||||||.|::||||||::|.|||.||||||:||.|.:.:..:..  ..||.|..||
Mouse   810 TPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRI 874

  Fly   611 LVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL---------------KDVITHHAAL--DLEAIE 658
            ||||.:.:|...|::|:|..|.:.:.|||::|               :...||.||.  ||....
Mouse   875 LVTHTLHVLPQADRILVLANGTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFP 939

  Fly   659 ADKQQVKRVLSQVDRTS-------KQLSKGEEKDPATIQDENG---NAEQQ--LQGAVSYDTYKA 711
            ..    .|...:.||..       |..|..|.:..|::.|...   .||:.  ..|.|....|.:
Mouse   940 GG----GRPTCRPDRPRPTEAAPVKGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLS 1000

  Fly   712 YFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW-ATWEEDRGYDSVDDYEATRTKMVIWYTVL 775
            |.||:|.| |....|.:|:    ||.|.......| :.|.:|...|....:.|.|.    |...|
Mouse  1001 YLRAVGTP-LCTYTLFLFL----CQQVASFSQGYWLSLWADDPVVDGRQMHAALRG----WVFGL 1056

  Fly   776 LLLTLALFLLRTFGFFFM-CLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVN 839
            |....|:.|..:....|: ..|.|..|...|...:.|:.:.||...|.|.:|||||.:...|||:
Mouse  1057 LGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVD 1121

  Fly   840 LPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVIL----LYF-CRALYIGASRSLKRIESL 899
            :|..:...|.:...::.|.:.|.:|.     |.||:.||    ||. .::||:..|..|:|:||.
Mouse  1122 IPDKLRSLLTYAFGLLEVGLAVTMAT-----PLAIVAILPLMVLYAGFQSLYVATSCQLRRLESA 1181

  Fly   900 TRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLI--CVI 962
            ..|.:.||..:||.|...:|:..|............:.|....|..:.|:|..:...:|:  .::
Mouse  1182 RYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLV 1246

  Fly   963 YILAVTFSFLVINQSFYS-GDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSE 1026
            ::.|   :..|::::..| |.||.:::.::.:....||.:|...::||:|.:||||.:||:.|.|
Mouse  1247 FVAA---TCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKE 1308

  Fly  1027 PPLESPKSVNLAAE--WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSS 1089
            .|...|   ..||:  ||..|.:.|:|..:|:.|.....::|::.:....||:||||||||||||
Mouse  1309 APWRLP---TCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSS 1370

  Fly  1090 IIQALFRL-ALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLW 1153
            :...|.|| ...||.|.|||:.|..:|||.|||||:|||||||||.|:||.|||...|.:||.:|
Mouse  1371 LAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIW 1435

  Fly  1154 SALDDVKLKKHVASLEGGL 1172
            :||:.|:||..|.||.|.|
Mouse  1436 AALETVQLKAFVTSLPGQL 1454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	363/1246 (29%)
		ABC_membrane	95..360	CDD:294371	59/280 (21%)
		ABCC_MRP_domain1	428..632	CDD:213217	81/205 (40%)
		ABC_membrane	728..994	CDD:294371	71/275 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	67/129 (52%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	366/1254 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740