Protein Alignment CG10505 and Abcc6

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_006541009.1
• Gene: Abcc6 / 27421
• MGIID: 1351634
• Length: 1500
• Species: Mus musculus
• Alignment Length: 1254
• Identity: 366/1254 - (29%)
• Similarity: 593/1254 - (47%)
• Gaps: 152/1254 - (12%)

  Fly     4 SKQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWE 68
            |:.|.|.... |..:|:..||.:|.|...:..:|.::.|....|:.......||.|...|:..|.
Mouse   268 SEDSQPLNPC-PEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWR 331

  Fly    69 K-------------------------ESKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQ 108
            :                         |..::.| |:|.|::|:...|     |...|.:.|....
Mouse   332 RSCNGLPGHKGHSSVGAPETEAFLQPERSQRGP-LLRAIWRVFRSTF-----LLGTLSLVISDAF 390

  Fly   109 PLLLGGLISYFA--YGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLV 171
            ...:..|:|.|.  .|....:..:.:|.|:.:...:.:.:|.....|:....:..|:|.|..|||
Mouse   391 RFAVPKLLSLFLEFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLV 455

  Fly   172 YRKCL-RASASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYL------MTRQV 229
            |||.| .:|.|......|..::::|:|:.:...:..:.:.||      .:|.::      :.:.:
Mouse   456 YRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLW------LLFLWIFVCFVYLWQLL 514

  Fly   230 GWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRL 294
            |.::|..:|..:.|:||..:..|..........:.:.:|.:|.:.::..::.||.:.||.:|...
Mouse   515 GPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLER 579

  Fly   295 IAAVRQSEVKAIRGSMSIYAALQCTNMIS-KISLFLSLVAYVYVGDLVT------AKKVFILSSY 352
            :..:|..|:.|::.|..:::    .:::| ::|.||..:....|..||.      |:|.|:..:.
Mouse   580 LLHIRGQELSALKTSTLLFS----VSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTV 640

  Fly   353 YGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGR 417
            ..:||.:.. :.|.::....|..||..|:..||           |.:    |:|......:.|.|
Mouse   641 LSILNKAQA-FLPFSVHCIVQARVSFDRLAAFL-----------CLE----EVDPNGMIASNSRR 689

  Fly   418 LHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILG 482
                 |....:|....:.:|.:.|     .|.:.||:..:..|..:.:||.||:|||:||.|:||
Mouse   690 -----SSKDRISVHNGTFAWSQES-----PPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLG 744

  Fly   483 EIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDA 547
            |:..::|.|.:.|.::|..|:.||...|:.||:.|.::.:....:.|:.||.|..|:...|.|..
Mouse   745 ELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVH 809

  Fly   548 TVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRI 610
            |.:||:|::||||||.|::||||||::|.|||.||||||:||.|.:.:..:..  ..||.|..||
Mouse   810 TPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRI 874

  Fly   611 LVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL---------------KDVITHHAAL--DLEAIE 658
            ||||.:.:|...|::|:|..|.:.:.|||::|               :...||.||.  ||....
Mouse   875 LVTHTLHVLPQADRILVLANGTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFP 939

  Fly   659 ADKQQVKRVLSQVDRTS-------KQLSKGEEKDPATIQDENG---NAEQQ--LQGAVSYDTYKA 711
            ..    .|...:.||..       |..|..|.:..|::.|...   .||:.  ..|.|....|.:
Mouse   940 GG----GRPTCRPDRPRPTEAAPVKGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLS 1000

  Fly   712 YFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW-ATWEEDRGYDSVDDYEATRTKMVIWYTVL 775
            |.||:|.| |....|.:|:    ||.|.......| :.|.:|...|....:.|.|.    |...|
Mouse  1001 YLRAVGTP-LCTYTLFLFL----CQQVASFSQGYWLSLWADDPVVDGRQMHAALRG----WVFGL 1056

  Fly   776 LLLTLALFLLRTFGFFFM-CLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVN 839
            |....|:.|..:....|: ..|.|..|...|...:.|:.:.||...|.|.:|||||.:...|||:
Mouse  1057 LGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVD 1121

  Fly   840 LPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVIL----LYF-CRALYIGASRSLKRIESL 899
            :|..:...|.:...::.|.:.|.:|.     |.||:.||    ||. .::||:..|..|:|:||.
Mouse  1122 IPDKLRSLLTYAFGLLEVGLAVTMAT-----PLAIVAILPLMVLYAGFQSLYVATSCQLRRLESA 1181

  Fly   900 TRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLI--CVI 962
            ..|.:.||..:||.|...:|:..|............:.|....|..:.|:|..:...:|:  .::
Mouse  1182 RYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLV 1246

  Fly   963 YILAVTFSFLVINQSFYS-GDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSE 1026
            ::.|   :..|::::..| |.||.:::.::.:....||.:|...::||:|.:||||.:||:.|.|
Mouse  1247 FVAA---TCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKE 1308

  Fly  1027 PPLESPKSVNLAAE--WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSS 1089
            .|...|   ..||:  ||..|.:.|:|..:|:.|.....::|::.:....||:||||||||||||
Mouse  1309 APWRLP---TCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSS 1370

  Fly  1090 IIQALFRL-ALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLW 1153
            :...|.|| ...||.|.|||:.|..:|||.|||||:|||||||||.|:||.|||...|.:||.:|
Mouse  1371 LAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIW 1435

  Fly  1154 SALDDVKLKKHVASLEGGL 1172
            :||:.|:||..|.||.|.|
Mouse  1436 AALETVQLKAFVTSLPGQL 1454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	363/1243 (29%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	366/1254 (29%)