DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcc8

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_037171.2	Gene:	Abcc8 / 25559	RGDID:	3786	Length:	1582	Species:	Rattus norvegicus

Alignment Length:	1411	Identity:	414/1411 - (29%)
Similarity:	685/1411 - (48%)	Gaps:	198/1411 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKL------YEHLPSFDSESLTRNLQPHWEKESKK 73
            ||:  |::||..:.||::..:...::.:|...:      ...|.::....|..:.|...:.:|::
  Rat   220 PFV--NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCLAFDAQARKDTQSQQ 282

  Fly    74 KNPSLMRLIFKVYGWQFV----------------PVCI--LYSLLEMAIHSFQP--LLLGGLISY 118
            ...::.|.:...:|.:.|                |:||  :...|....|.|||  ..||   .|
  Rat   283 GARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLG---VY 344

  Fly   119 FAYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS- 182
            |...|..:  .:||:.|:.:.|..|:.........:.....|..:|.|....:|.|.:..|.|:
  Rat   345 FVSSQEFL--GNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNL 407

  Fly   183 --GEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIP 245
              ||...||..::::||.:|....|:...:||..||:..:...|:...:|.::|||.|.|::|.|
  Rat   408 SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAP 472

  Fly   246 LQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSM 310
            :|.:.|...:.....:.::.:.|:|..||::..|:::|:||||..|...:...|:.|:.::| :.
  Rat   473 VQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLR-AF 536

  Fly   311 SIYAALQCTNMISKISLFLSLVAYVYVGDL---------------------VTAKKVFILSSYYG 354
            ::|.::   ::....::.::.|...:||.:                     :....:|:|||
  Rat   537 AVYTSI---SIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSS--- 595

  Fly   355 LLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEK---------- 409
                        .:.:..:.|||.:::.|||...| ..||.|....|..:..|.|
  Rat   596 ------------VVRSTVKALVSVQKLSEFLSSAE-IREEQCAPREPAPQGQAGKYQAVPLKVVN 647

  Fly   410 -PKPAQS------GRLHCVQSETK------CLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQ 461
             .:||:.      |.|..:...|.      |:.......:|....|     |.:..|:..|..||
  Rat   648 RKRPAREEVRDLLGPLQRLTPSTDGDADNFCVQIIGGFFTWTPDGI-----PTLSNITIRIPRGQ 707

  Fly   462 FVGIVGNVGSGKSTLLHAILGEIELMQGRV---------------------------EVHGRISY 499
            ...|||.||.|||:||.|.|||::.:.|.|                           ...|.::|
  Rat   708 LTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAY 772

  Fly   500 AAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKAR 564
            |:|:||:...::.|||.|...:.::||:.|:.||.|..|:::||.||.|.:|||||:|||||:.|
  Rat   773 ASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQR 837

  Fly   565 IALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLL--DGKMRILVTHHVQLLKSVDQLLL 627
            |::|||:|:..::...|||.:|:|..:...||......||  |.:..:||||.:|.|...|.::.
  Rat   838 ISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIA 902

  Fly   628 LEGGKLTQQGS-----------YEELKDVITHH-AALDLEAIEADK-----QQVKRVLSQVDRTS 675
            ::.|.:.::|:           :|..|.::... ..|:.|.:...|     |.:.|.:|  .|..
  Rat   903 MKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMS--SRDG 965

  Fly   676 KQLSKGEEKDPATIQDENGNAEQQL--QGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAV 738
            ..|.:.||::.|...:|:.|....|  :..:.:.....|..:.|     .|:||:.|.::..:.:
  Rat   966 LLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAG-----ILLLSLLVFSQLLKHM 1025

  Fly   739 MDIFISRW-ATWEED--------RGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMC 794
            :.:.|..| |.|.:.        |......:....::...:.:|||..|.:||.|:.:....:..
  Rat  1026 VLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTG 1090

  Fly   795 LRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLP---QAMMDSLQFLVDVVA 856
            |:::..||..|.:.||.|.|.||...|.|.:|||||||...:|.::|   :.:..|....|..:|
  Rat  1091 LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALA 1155

  Fly   857 VLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSM 921
            |:..|.......|:|.|   ::.||.:..:..|||.|::::..|:.|:.||..:|..|.:|||:.
  Rat  1156 VISYVTPVFLVALLPLA---VVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAF 1217

  Fly   922 DAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDL------ICVIYILAVTFSFLVINQSFYS 980
            ....:.:|....:.::|:.|.....:|||    |.::      .||:.|.|.|.....:::...:
  Rat  1218 RYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMEYIGACVVLIAAATSISNSLHRELSA 1278

  Fly   981 GDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSE------PPLESPKSVNLAA 1039
            |.|||.:|.::.:.....|.:|..|:||..:.:|:|:....:|.:|      .|...||:
  Rat  1279 GLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKN----- 1338

  Fly  1040 EWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGT 1103
             ||..|.::.|:|.:||....:.:|:.:|....|.:||||.||||:||||...|.||:. :.||.
  Rat  1339 -WPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGR 1402

  Fly  1104 IEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASL 1168
            |.|||:||.||.||.||||:|||.|||||||||:||||||..:.||.:||.||:..:||..|.:|
  Rat  1403 IIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKAL 1467

  Fly  1169 EGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECT 1233
            .|||...:.:||.|||.|||||.|||||.:|:..:.:||||||::|..|:.::|:.:.|.||:.|
  Rat  1468 PGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRT 1532

  Fly  1234 VLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            |:|||||:||::..|.|:|:..|.|:||..|.|||.:||......|
  Rat  1533 VVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFV 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	409/1398 (29%)
		ABC_membrane	95..360	CDD:294371	68/292 (23%)
		ABCC_MRP_domain1	428..632	CDD:213217	78/232 (34%)
		ABC_membrane	728..994	CDD:294371	74/283 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	114/219 (52%)
Abcc8	NP_037171.2	CFTR_protein	223..1582	CDD:273530	412/1406 (29%)
		ABC_membrane	<375..590	CDD:279056	48/218 (22%)
		P-loop_NTPase	679..907	CDD:304359	78/232 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..768		0/26 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..962		6/24 (25%)
		ABC_membrane	1017..1295	CDD:279056	74/284 (26%)
		ABCC_SUR2	1343..1582	CDD:213255	121/236 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740