DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Tap2

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_114445.2	Gene:	Tap2 / 24812	RGDID:	3818	Length:	703	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	165/645 - (25%)
Similarity:	274/645 - (42%)	Gaps:	115/645 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   682 EEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW 746
            :||:|.   .||..|            .......|..|.|..|:::...||             .
  Rat   125 QEKEPG---QENNRA------------LMIRLLRLSKPDLPFLIVAFIFLA-------------M 161

  Fly   747 ATWEE-------DRGYDSV-DDYEATRTKMVIWYTVLLLLTLALFL-LRTFGFFFMCLRISLTLH 802
            |.|.|       .|..|.: .|::.......|::..|..:..:|.. .|...|.|...||:|.:.
  Rat   162 AVWGETLIPHYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSLSAGCRGGSFLFTMSRINLRIR 226

  Fly   803 DQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYW 867
            :||:..::|..:.||....:|.:.:|.|||...:...||......|:.||.||.:.       |:
  Rat   227 EQLFSSLLRQDLAFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLY-------YF 284

  Fly   868 LLIPAAIMVILLYFCRALYIGASR--------SLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAM 924
            :|..:..:..|......|.|.|.:        .||.|:.:. :.......:...|..|:||..|.
  Rat   285 MLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDVV-AKAGQVVREAVGGLQTVRSFGAE 348

  Fly   925 PQLEQTFHGHQNTNSSALFLYVSANRAFSFW--TDLICVIY-----ILAVTFSFLVIN---QSFY 979
            .|....:       ..||      .|....|  .||...:|     ::|:....|::|   |...
  Rat   349 EQEVSRY-------KEAL------ERCRQLWWRRDLEKELYLVIRRVMALGMQVLILNCGVQQIL 400

  Fly   980 SGDVGLAITQSMTLV----------IMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKS 1034
            :|:|......|..|.          ::..:|     :|.:|:.:.|:|..|..  ..|.|  ||.
  Rat   401 AGEVTRGGLLSFLLYQEEVGHHVRNLVYMYG-----DMLSNVGAAEKVFSYLD--RRPNL--PKP 456

  Fly  1035 VNLAAEWPQA-GHLRFQDLRMRY-SPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSI---IQAL 1094
            ..||.  |:. |.:.|||:...| |..::.:|:||.|...|.:...:||..|:|||::   :|.|
  Rat   457 GTLAP--PRVEGRVEFQDVSFSYPSRPEKPVLQGLTFTLHPGKVTALVGPNGSGKSTVAALLQNL 519

  Fly  1095 FRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLD-PFDEKSDESLWSALDD 1158
            ::  ...|.:.:||..:.:...|.|..::.::.|:||||||:::.|:. ......|..:.:|...
  Rat   520 YQ--PTGGKVLLDGEPLVQYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRNCEDAQVMAAAQA 582

  Fly  1159 VKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQE 1223
            ......:..:..|::..:.:.||..::||:|.:.:|||::|..|||::||||:.:|.|    .::
  Rat   583 ACADDFIGEMTNGINTEIGERGSQLAVGQKQRLAIARALVRNPRVLILDEATSALDAE----CEQ 643

  Fly  1224 TIQT--KFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQ 1281
            .:||  ...:.|:|.||||||||.:.|.|||:..||:||    |..|:.:......||.|
  Rat   644 ALQTWRSQEDRTMLVIAHRLHTVQNADQVLVLKQGQLVE----HDQLRDEQDVYAHLVQQ 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	161/630 (26%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217
		ABC_membrane	728..994	CDD:294371	63/292 (22%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	73/225 (32%)
Tap2	NP_114445.2	3a01208	1..697	CDD:273363	162/641 (25%)
		ABC_membrane	156..416	CDD:279056	64/293 (22%)
		P-loop_NTPase	457..680	CDD:304359	73/230 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000