DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcc1

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_071617.2	Gene:	Abcc1 / 24565	RGDID:	3112	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	1415	Identity:	475/1415 - (33%)
Similarity:	737/1415 - (52%)	Gaps:	226/1415 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSPKRESNPF--IKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEK 69
            |...|:.||.  ..|:.:|:..|.|:..:..:|.|:.|.:|.|:.......||.:...|..:|:|
  Rat   199 SETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKK 263

  Fly    70 E------------------------------------------SKKKNPSLMRLIFKVYGWQFVP 92
            |                                          .|.::|||.::::|.:|..|
  Rat   264 ECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYF-- 326

  Fly    93 VCILYSLLEMAIHSFQ----PLLLGGLISYFAYGQTTVTKESA-----YLYAMGIVLCSLVTSLV 148
               |.|.|..|:|...    |.:|..:|::       |....|     |||...:.:.:.:.:|.
  Rat   327 ---LMSFLYKALHDLMMFAGPEILELIINF-------VNDREAPDWQGYLYTALLFVSACLQTLA 381

  Fly   149 FHPFMFYVFAVGTRVRLACAGLVYRKCL------RASASSGEGLGGQAISVMSIDLSQF-DLTFY 206
            .|.:....|..|.|::.|..|.||||.|      |.|::.||     .:::||:|..:| ||..|
  Rat   382 LHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGE-----IVNLMSVDAQRFMDLATY 441

  Fly   207 FFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKL 271
             .:.:|..|::..:..|.:...:|.:.|.|:|.:::::|..|..|..:.::.....|.:|.|:||
  Rat   442 -INMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKL 505

  Fly   272 MNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYA----ALQCTNMISKISLFLSLV 332
            ||||:..|:|:|:||||.:|...:..:||.|:|.::.|..:.|    ...||..:..:|.|...|
  Rat   506 MNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFV 570

  Fly   333 AYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCC 397
            . |...:::.|||.|:..:.:.:|... |:..||.|::..|..||.:|:..||...|
  Rat   571 T-VDEKNILDAKKAFVSLALFNILRFP-LNILPMVISSIVQASVSLKRLRIFLSHEE-------- 625

  Fly   398 RDNPGLELDA-EKPKPAQSGRLHCVQSETKCLSFRKVSASW--DKPSIKQPRKPHIEGISFHINA 459
                 ||.|: |:......|.::.:       :.:..:.:|  |:|       |.:.||:|.|..
  Rat   626 -----LEPDSIERWSIKDGGGMNSI-------TVKNATFTWARDEP-------PTLNGITFAIPD 671

  Fly   460 GQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEK 524
            |..|.:||.||.|||:||.|:|.|::.::|.|.:.|.::|..||.|:...|:||||||....:|.
  Rat   672 GALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEH 736

  Fly   525 RYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDA 589
            .|:||:.||.|..|||:||.||.|.:||:|::||||||.|::||||||..:||||.||||:||||
  Rat   737 CYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDA 801

  Fly   590 QVGKLLMDKCF--HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKD-------- 644
            .|||.:.:|..  ..||..|.||||||.:..|..||.::::.|||:::.|||:||.|
  Rat   802 HVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEF 866

  Fly   645 VITH-HAALDLEAIEADKQQVKRVLSQVDRTSK------------------QLSKGEEKDPATIQ 690
            |.|: :...||    |.:...|..:|.:.:.||                  .||........|.|
  Rat   867 VRTYANTEQDL----ASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQ 927

  Fly   691 DENGNAEQQLQGA-----------------VSYDTYKAYFRALGAPFLVCL-VLSMFVLARGCQA 737
            ..:..||.|..|.                 |....|..|.:|:|    :|: .||:|:..  |..
  Rat   928 QHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIG----LCISFLSIFLFL--CNH 986

  Fly   738 VMDIFISRW-ATWEEDRGYDSVDDYEATRT-KMVIWYTVLLLLTLALF---LLRTFGFFFMCLRI 797
            |..:..:.| :.|.:||  .:|:..:..|. ::.::..:.:|..:|:|   :..:.|..|...|
  Rat   987 VSALASNYWLSLWTDDR--PAVNGTQENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRR- 1048

  Fly   798 SLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVA 862
               ||..|...::|:.|.||...|||.::||||.::..||..:||.:...:..|..|:..::|:.
  Rat  1049 ---LHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIIL 1110

  Fly   863 IANYWLLIPAAIMVI-----LLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMD 922
            :|.     |.|.::|     :.:|.:..|:.:||.|||:||::|||:|||.|:|..|.|.||:.:
  Rat  1111 LAT-----PIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFE 1170

  Fly   923 AMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLI--CVIYILAVTFSFLVINQ-SFYSGDVG 984
            ...:..:......:.|..|.:..:.|||..:...:.:  |::...|:   |.||:: |..:|.||
  Rat  1171 EQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL---FAVISRHSLSAGLVG 1232

  Fly   985 LAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSE---------PPLESPKSVNLAAE 1040
            |:::.|:.:.....|.:|.::|||.|:.:|||:.||::|..|         ||          :.
  Rat  1233 LSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPP----------ST 1287

  Fly  1041 WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLALN-EGTI 1104
            ||.:|.:.|:|..:||....:.:|:.:|...:..||:||||||||||||:...|||:..: ||.|
  Rat  1288 WPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEI 1352

  Fly  1105 EIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLE 1169
            .|||::|.|:|||:||.:|:|||||||||||:||.|||||.:.|||.:|.||:...||..|::|.
  Rat  1353 IIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALP 1417

  Fly  1170 GGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTV 1234
            ..|:....:||.|.|:|||||||||||:||:.::||:|||||.||.|||.|||.||:|:|.:.||
  Rat  1418 DKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTV 1482

  Fly  1235 LTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQR--------KDGALL 1276
            |||||||:|:||...|:|:|.|:|.|.|||.:|||:        ||..|:
  Rat  1483 LTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAKDAGLV 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	467/1392 (34%)
		ABC_membrane	95..360	CDD:294371	80/284 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	96/207 (46%)
		ABC_membrane	728..994	CDD:294371	77/278 (28%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	122/219 (56%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	474/1412 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660