DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10505 and Abcc12

DIOPT Version :9

Sequence 1:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_766500.3 Gene:Abcc12 / 244562 MGIID:2441679 Length:1366 Species:Mus musculus


Alignment Length:1364 Identity:449/1364 - (32%)
Similarity:723/1364 - (53%) Gaps:145/1364 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKKKNP-- 76
            ||...|.::|...|.|:..|..:..:..|....|....|...|:...:..|..||:|.|:..|  
Mouse    44 NPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDINAKRFQILWEEEIKRVGPEK 108

  Fly    77 -SLMRLIFKVYGWQF----VPVCILYSLLEMAIHSFQP-LLLGGLISYFAYGQTTVTKESAYLYA 135
             ||.|::     |:|    |.:.::.::|.:.:.:..| :|:..::.:       :|..|:....
Mouse   109 ASLGRVV-----WKFQRTRVLMDVVANILCIVMAALGPTVLIHQILQH-------ITSISSGHIG 161

  Fly   136 MGIVLCSLVTSLVFHPFMFYVFA------VGTRVRLACAGLVYRKCL------RASASSGEGLGG 188
            :||.||..:.:..|...:|:..|      ...|:::|.:.|::...|      ..||       |
Mouse   162 IGICLCLALFTTEFTKVLFWALAWAINYRTAIRLKVALSTLIFENLLSFKTLTHISA-------G 219

  Fly   189 QAISVMSID-LSQFDLTFYFFHDLWKGPVEA---------CIFGYLMTRQVGWTSLIGIAFIVIL 243
            :.::::|.| .|.|:...:.       |:.|         .::.:.:   :|.|:|:||:..:|.
Mouse   220 EVLNILSSDSYSLFEAALFC-------PLPATIPILMVVCAVYAFFI---LGSTALVGISVYLIF 274

  Fly   244 IPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRG 308
            ||:|.:.||.:::|...:....|.||:.|||.:..|::|||||||:||...|..:|:.|.|.:..
Mouse   275 IPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIRKREKKLLEK 339

  Fly   309 S---MSIYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITT 370
            :   .|..:||  ..::|.|::..:...::::...:||...|.:.:.:.::..|:. ..|.::..
Mouse   340 AGYVQSGNSAL--APIVSTIAIVSTFTCHIFLKRKLTAPVAFSVIAMFNVMKFSIA-ILPFSVKA 401

  Fly   371 WAQTLVSARRVVEFLLQVEKPTEESCCRD--------NPGLELDAE-----KPKPAQSGRLHCVQ 422
            .|:..||.||:.:.|:....|:..:...|        |..|..:.|     .|..||..:.|..:
Mouse   402 VAEASVSLRRMKKILIAKSPPSYITQPEDPDTILLLANATLTWEQEINRKSDPPKAQIQKRHVFK 466

  Fly   423 SETKCLSFRK-------VSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAI 480
            .:...|...:       .|..|...|.|..    :..|||.:..|:.:||.||||||||:|:.|:
Mouse   467 KQRPELYSEQSRSDQGVASPEWQSGSPKSV----LHNISFVVRKGKVLGICGNVGSGKSSLISAL 527

  Fly   481 LGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRG 545
            ||:::|.:|.|.|:|.::|.:||.|:|.|::||||||.|:|..:||:..||.|.|.:||..||.|
Mouse   528 LGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYG 592

  Fly   546 DATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRI 610
            |.|.:||||::|||||:.||:||||||....:||.||||:||||.|||.:.::|..:.|.||..:
Mouse   593 DLTEIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGKTVV 657

  Fly   611 LVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAAL--DLEAIE----------ADKQQ 663
            ||||.:|.|:|.|:::|||.|::.::|:::||.:....:|.|  :|..::          |..:.
Mouse   658 LVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHIYNVAMVET 722

  Fly   664 VKRVLSQVDRTSKQLSKGEEKD----PATIQ--DENGNAEQQLQ------GAVSYDTYKAYFRAL 716
            :|...:|.|..: .|:.|:|||    |.|.:  |.|..|.|.:|      |.|::.||..|.:|.
Mouse   723 LKESPAQRDEDA-VLASGDEKDEGKEPETEEFVDTNAPAHQLIQTESPQEGIVTWKTYHTYIKAS 786

  Fly   717 GAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYD------------SVDD-YEATRTKM 768
            |...:..|||.:|.|..|..|....::..|.    |||..            :||. .:.|:..|
Mouse   787 GGYLVSFLVLCLFFLMMGSSAFSTWWLGIWL----DRGSQVVCASQNNKTACNVDQTLQDTKHHM 847

  Fly   769 V-IWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSD 832
            . :.|...::..|...:::.|.|....|..|.:||:::::.|:|:.|.||:..|:||::||||.|
Mouse   848 YQLVYIASMVSVLMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRFSKD 912

  Fly   833 IQNVDVNLPQAMMDSLQFLVDVVAVLVIV-AIANYWLLIPAAIMVILLYFCRALYIGASRSLKRI 896
            :..:||.||....:.||....||.:|||: |:....|::.|.:.||.|...|..:.|. :.||::
Mouse   913 MDELDVRLPFHAENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGV-QELKQV 976

  Fly   897 ESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLI-- 959
            |:::|||.:||...:..|...|.:.|........|....:.|||.|..:..|.|.|:...|::  
Mouse   977 ENISRSPWFSHITSSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDILMN 1041

  Fly   960 CVIYILA--VTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQ 1022
            .|.:::|  ||.||..|:.|    ..||:::..:.|..:.|..:|...|.:...||.|.:.||..
Mouse  1042 IVTFVVALLVTLSFSSISAS----SKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLREYIL 1102

  Fly  1023 TPSEPPLESPKSVNLA-AEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAG 1086
            | ..|....|..|... .:||..|.:.|:|.||||......:|.|||...|..:.:|||||||:|
Mouse  1103 T-CVPEHTHPFKVGTCPKDWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSG 1166

  Fly  1087 KSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDE 1150
            |||:..|||||. ...|||.||.:||..:||.|||:::::||||||||.||:|:||||....:||
Mouse  1167 KSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDE 1231

  Fly  1151 SLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDT 1215
            .||..|:...::..:..|...|...:.:.|.|||:|:|||:|:|||:||.::::::|||||::|:
Mouse  1232 MLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDS 1296

  Fly  1216 ETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            :||.|:|.||:..|..||||||||||:||::.|.||||:.|:::||..|..|.::.|.|...|:
Mouse  1297 KTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKPEVLAEKPDSAFAMLL 1360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 445/1351 (33%)
ABC_membrane 95..360 CDD:294371 65/290 (22%)
ABCC_MRP_domain1 428..632 CDD:213217 100/210 (48%)
ABC_membrane 728..994 CDD:294371 82/284 (29%)
ABCC_MRP_domain2 1045..1264 CDD:213211 109/219 (50%)
Abcc12NP_766500.3 MRP_assoc_pro 43..1366 CDD:188098 449/1364 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 470..492 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 726..749 7/23 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841704
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.660

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