Protein Alignment CG10505 and Abcc8

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_036008753.1
• Gene: Abcc8 / 20927
• MGIID: 1352629
• Length: 1597
• Species: Mus musculus
• Alignment Length: 1430
• Identity: 411/1430 - (28%)
• Similarity: 687/1430 - (48%)
• Gaps: 221/1430 - (15%)

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKL------------YEHL-PSFDSESLTRNLQPH 66
            ||:  |::||..:.||::..:...|:.:|...:            |:.| .:||:       |..
Mouse   220 PFV--NLLSKGTYWWMNAFIKTAHRKPIDLRAIGKLPIAMRALTNYQRLCAAFDA-------QAR 275

  Fly    67 WEKESKKKNPSLMRLIFKVYGWQFV----------------PVCI--LYSLLEMAIHSFQP--LL 111
            .:.:|::...::.|.:...:|.:.|                |:||  :...|....|.|||  ..
Mouse   276 KDTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQF 340

  Fly   112 LGGLISYFAYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCL 176
            ||   .||...|..:  .:||:.|:.:.|..|:.........:.....|..:|.|....:|.|.:
Mouse   341 LG---VYFVSSQEFL--GNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIM 400

  Fly   177 RASASS---GEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIA 238
            ..|.|:   ||...||..::::||.:|....|:...:||..||:..:...|:...:|.::|||.|
Mouse   401 HLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAA 465

  Fly   239 FIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEV 303
            .|::|.|:|.:.|...:.....:.::.:.|:|..||::..|:::|:||||..|...:...|:.|:
Mouse   466 VIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEM 530

  Fly   304 KAIRGSMSIYAALQCTNMISKISLFLSLVAYVYVGDL---------------------VTAKKVF 347
            .::| :.::|.::   ::....::.::.|...:||.:                     :....:|
Mouse   531 TSLR-AFAVYTSI---SIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLF 591

  Fly   348 ILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEK--- 409
            :|||               .:.:..:.|||.:::.|||...| ..||.|....|..:..|.|
Mouse   592 LLSS---------------VVRSTVKALVSVQKLSEFLSSAE-IREEQCAPREPAPQGQAGKYQA 640

  Fly   410 --------PKPAQS------GRLHCV------QSETKCLSFRKVSASWDKPSIKQPRKPHIEGIS 454
                    .:||:.      |.|..:      .::..|:.......:|....|     |.:..|:
Mouse   641 VPLKVVNRKRPAREEVRDLLGPLQRLTPSMDGDADNFCVQIIGGFFTWTPDGI-----PTLSNIT 700

  Fly   455 FHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRV---------------------------- 491
            ..|..||...|||.||.|||:||.|.|||::.:.|.|
Mouse   701 IRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETA 765

  Fly   492 -----EVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVG 551
                 ...|.::||:|:||:...::.|||.|...:.::||:.|:.||.|..|:::||.||.|.:|
Mouse   766 ADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIG 830

  Fly   552 ERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLL--DGKMRILVTH 614
            ||||:|||||:.||::|||:|:..::...|||.:|:|..:...||......||  |.:..:||||
Mouse   831 ERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTH 895

  Fly   615 HVQLLKSVDQLLLLEGGKLTQQGS-----------YEELKDVITHH-AALDLEAIEADK-----Q 662
            .:|.|...|.::.::.|.:.::|:           :|..|.::... ..|:.|.:...|     |
Mouse   896 KLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQ 960

  Fly   663 QVKRVLSQVDRTSKQLSKGEEKDPATIQDENGNAEQQL--QGAVSYDTYKAYFRALGAPFLVCLV 725
            .:.|.:|  .|....|.:.||::.|...:|:.|....|  :..:.:.....|..:.|.     |:
Mouse   961 GLPRAMS--SRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGV-----LL 1018

  Fly   726 LSMFVLARGCQAVMDIFISRW-ATWEED--------RGYDSVDDYEATRTKMVIWYTVLLLLTLA 781
            ||:.|.::..:.::.:.|..| |.|.:.        |......:....::...:.:|||..|.:|
Mouse  1019 LSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIA 1083

  Fly   782 LFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMD 846
            |.|:.:....:..|:::..||..|.:.||.|.|.||...|.|.:|||||||...:|.::|..:..
Mouse  1084 LCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLEC 1148

  Fly   847 SLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQT 911
            ..:..:..|:.|.:::......|:....:.::.||.:..:..|||.|::::..|:.|:.||..:|
Mouse  1149 LSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAET 1213

  Fly   912 FHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDL---------------ICV 961
            ..|.:|||:.....:.:|....:.::|:.|.....:|||    |.::               .||
Mouse  1214 VEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMPGPAAVLPQEYIGACV 1274

  Fly   962 IYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSE 1026
            :.|.|.|.....:::...:|.|||.:|.::.:.....|.:|..|:||..:.:|:|:....:|.:|
Mouse  1275 VLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAE 1339

  Fly  1027 ------PPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGA 1085
                  .|...||:      ||..|.::.|:|.:||....:.:|:.:|....|.:||||.||||:
Mouse  1340 SYEGLLAPSLIPKN------WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGS 1398

  Fly  1086 GKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSD 1149
            ||||...|.||:. :.||.|.|||:||.||.||.||||:|||.|||||||||:||||||..:.||
Mouse  1399 GKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSD 1463

  Fly  1150 ESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVD 1214
            .:||.||:..:||..|.:|.|||...:.:||.|||.|||||.|||||.:|:..:.:||||||::|
Mouse  1464 STLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASID 1528

  Fly  1215 TETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            ..|:.::|:.:.|.||:.||:|||||:||::..|.|:|:..|.|:||..|.|||.:||......|
Mouse  1529 MATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFV 1593

  Fly  1280  1279
            Mouse  1594  1593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	408/1420 (29%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	408/1424 (29%)