DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and mrp-8

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_499598.2	Gene:	mrp-8 / 190710	WormBaseID:	WBGene00003414	Length:	1461	Species:	Caenorhabditis elegans

Alignment Length:	1376	Identity:	430/1376 - (31%)
Similarity:	690/1376 - (50%)	Gaps:	177/1376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSPKR--------ESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNL 63
            ||.||        |..|..|::.:||..|.|::.:.|.|.::.|....|:....:..||.|....
Worm   161 SSTKRLGEDEQKIEQTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESLHNLNENATSEWLYTRW 225

  Fly    64 QPHWEKESKKKNPSLMRLIFKVYGWQFVPV----CILYSLLEMA---IHSFQPLLLGGLISYFAY 121
            :..::||...:......::     |.|:.:    .|..:|..:.   :|...|:||..||.|.:.
Worm   226 RAEFDKEKAGRKSGETSIV-----WPFIRIQRATIITLTLARLTADIVHYLNPILLKQLIDYVSL 285

  Fly   122 GQTTVTKESAYLYAMGIVL------CSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASA 180
            ....:        :.||.:      ||...||:.:..:..:.......:...:..:..|.||.|.
Worm   286 HDQPL--------SFGIAIACIMFSCSTTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSP 342

  Fly   181 SS-GEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILI 244
            |: .....|:.::..::|:.....:..:..::|..|.:..:...::...:||.::.|:..:::.|
Worm   343 SARSNRTAGEILNHAAVDIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFI 407

  Fly   245 PLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGS 309
            ||....::.......:..|.:|.|.||.||::..|:|:|:||||:||...|..:|..|||.:|..
Worm   408 PLNLCTSRFIKLSQQKQMKIKDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNV 472

  Fly   310 MSIYAALQCTNMISKISLFL-SLVAYVYVG---DLVTAKKVFILSSYYGLLNDSLLHYWPM---- 366
            ..:...:...|..|...:.: |...||...   :.:|....|:..:.:..|..      ||
Worm   473 CILSRIVDVANAASPFLVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQ------PMRMVA 531

  Fly   367 -AITTWAQTLVSARRVVEFL--LQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCL 428
             .|.|..|..||.:|:.:||  .::|:.||.:.                            ...:
Worm   532 NLINTLVQARVSNKRLRQFLNDEEMERKTEVAL----------------------------GNAI 568

  Fly   429 SFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEV 493
            .|:..|.:|..|.    ..|.::.:|..|..||.:.|||:||.|||:||.|:|.|:.|:.|||:|
Worm   569 VFKNASLNWKGPQ----NPPVLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRVKV 629

  Fly   494 HGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLS 558
            .|.|:|..|..|:|..:|:|||||..:.....|..||.:|||..|.....:|:.|:|||.||:||
Worm   630 GGSIAYVPQHSWIFNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLS 694

  Fly   559 GGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRILVTHHVQLLKS 621
            |||||||:||||||:..||||.||||:||||.||:.|.||..  ..||..|.|:||||::|..|.
Worm   695 GGQKARISLARAVYQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYTKY 759

  Fly   622 VDQLLLLEGGKLTQQGSYEEL------------------KDVITHHAALDLEAIEADKQQVKRVL 668
            ||.:.::|.|::.|.||:|::                  :||....|    |:.||.......||
Worm   760 VDTIYVIEDGQIVQHGSFEDIAYVDGPFGRLWSECENSDEDVADEEA----ESSEASVTPPVPVL 820

  Fly   669 -----------SQVDRTSKQLSKGEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALG----A 718
                       ||:|||:...|:...|.....|....|.|....|.|....|:.|.:.:|    :
Worm   821 ENGDNGAIEKSSQIDRTNSHFSEKSRKSEEKPQKVEKNVENVQLGRVKKSVYQLYIKTMGIFNSS 885

  Fly   719 PFLVCLVLSMFVLARGCQAVMDIFISRW-ATWEED---------------RGYDSVDDYEATRTK 767
            .||:..:....|:         |..|.| :.|..:               ....|||...:..|:
Worm   886 AFLIFFIAHFTVM---------IMRSLWLSDWSNENAAIKKATLSSVDYLNSTSSVDGPVSVETR 941

  Fly   768 MVIW--YTVLLLLTLAL-FLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRF 829
            ::::  :..|.:|.||| |.:.|.|    .||.|..||..|.|.::.|.:.||:..|:||::||.
Worm   942 LIVYAGFGGLEMLLLALAFTVLTIG----SLRASYGLHSPLIHALLVAPISFFDTTPTGRIINRL 1002

  Fly   830 SSDIQNVDVNLPQAMMDSL----QFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGAS 890
            |.|:..:|     .:.|::    |.|::...:||:::|:....|:.||.::::.||....||..|
Worm  1003 SRDLDVID-----KLQDNIRMCTQTLLNACMILVLISISTPIFLVCAAPLILIYYFVMIYYIPTS 1062

  Fly   891 RSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHG-HQNTNSSALFLYVS--ANRAF 952
            |.|||:||..||||.|...::.||.|:||:.|   :.|:|... ..|.:..|...|:|  :||..
Worm  1063 RQLKRLESANRSPILSTIAESIHGASSIRAFD---KTERTTTALSTNVDKFAQCRYLSHMSNRWL 1124

  Fly   953 SFWTDLI---CVIYI-LAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTS 1013
            :...:|:   ||::. |:.|.|......:  .|..||:::.::|:..:....:|..:|:|:|:.|
Worm  1125 ATRLELLGNTCVLFASLSATLSTKYFGLT--PGMAGLSVSYALTITEVLNICVRSVSEIESNIVS 1187

  Fly  1014 VERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIG 1078
            ||||.||.:...|.|....||:....:||..|.:......|||......:|:.::.:.:..|:||
Worm  1188 VERVNEYQKLEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRYRKNLPLVLKNIDLKIEGGERIG 1252

  Fly  1079 IVGRTGAGKSSIIQALFRLALNE-GTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLD 1142
            ::||||:||||:..||:|:...| |||:||.::|..:|||.|||::.||||:||:||||||||||
Worm  1253 VIGRTGSGKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFSGTLRFNLD 1317

  Fly  1143 PFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMD 1207
            ||::.||:.:|:.|:..:||:.....:..|...:.:||.|.|:|:|||:||.||:||..|::::|
Worm  1318 PFNQYSDDQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGERQLLCLCRALLRGARIVILD 1382

  Fly  1208 EATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKD 1272
            ||||:|||.||.::|..|:..|.:.|.::|||||.|::|:|.::|:|||::.||..|..||...|
Worm  1383 EATASVDTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLDAGRVAEFDTPSNLLLNPD 1447

  Fly  1273 GALLKLVNQND 1283
            ....:|:|:.:
Worm  1448 SLYSQLLNEKN 1458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	421/1346 (31%)
		ABC_membrane	95..360	CDD:294371	60/278 (22%)
		ABCC_MRP_domain1	428..632	CDD:213217	98/205 (48%)
		ABC_membrane	728..994	CDD:294371	84/295 (28%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	100/219 (46%)
mrp-8	NP_499598.2	CFTR_protein	173..1459	CDD:273530	426/1364 (31%)
		ABC_membrane	259..527	CDD:294371	59/281 (21%)
		ABCC_MRP_domain1	568..770	CDD:213217	98/205 (48%)
		ABC_membrane	887..1168	CDD:294371	86/303 (28%)
		ABCC_MRP_domain2	1219..1439	CDD:213211	100/219 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720